01607nas a2200193 4500008004100000022001400041245010200055210006900157260000900226300001100235490000700246520090900253100002001162700001901182700003001201700002701231700002401258856013101282 2026 eng d a0930-751600aOrganometallic reagent-mediated functionalization of aromatic compounds in continuous-flow system0 aOrganometallic reagentmediated functionalization of aromatic com cJUL  ae702730 v493 a

This review describes recent developments in the functionalization of aromatic and heteroaromatic scaffolds using a variety of accessible, reactive organometallic reagents (Li, Mg, Zn, Na, K, etc.) in a continuous-flow process. Many research groups notably demonstrated efficient large-scale conditions for the synthesis of highly functionalized arenes and heteroarenes in moderate to high yields. Flow reactions emphasize reaction scope, tolerance to a wide range of functional groups, clean reactions, commercial availability of starting materials, and high regio- and chemoselectivity. This process will support the sustainable development of biologically important heterocyclic compounds, as well as drugs and natural products. This article reviews work published between 2010 and 2025 and provides a detailed overview, with many applications in organic synthesis and medicinal chemistry.

1 aVasanth, Selvam1 aNavyatha, Jenu1 aSenthilkumar, Thanigaivel1 aSowntharya, Palanisamy1 aDhayalan, Vasudevan uhttps://library.ncl.res.in/content/organometallic-reagent-mediated-functionalization-aromatic-compounds-continuous-flow-system