01626nas a2200217 4500008004100000022001400041245013500055210006900190260000800259300001400267490000700281520083800288100001901126700002401145700001801169700001801187700002601205700002601231700002601257856012501283 2026 eng d a0022-326300aSulfonyl pyrazoles as sustainable dual functional group transfer reagents: AlCl3 promoted transfer of sulfonyl and pyrazole groups0 aSulfonyl pyrazoles as sustainable dual functional group transfer cMAY a6873-68830 v913 a

Herein, we report sulfonyl pyrazoles as sustainable dual-functional group transfer reagents for the transfer of two different functional groups to two different acceptors under mild conditions facilitated by AlCl3. The transformation proceeds via two distinct transition states: in the first, AlCl3 activates the S-N bond toward cleavage, and in the second, a sulfoximine nucleophilically attacks the sulfonyl group, resulting in the elimination of the pyrazole moiety. This process yields sulfonyl amidines, compounds with significant medicinal relevance, while the liberated pyrazole effectively participates in subsequent reactions with Michael acceptors. Notably, the protocol operates without the need for transition-metal catalysts and exhibits broad substrate scope along with excellent functional group tolerance.

1 aKour, Harpreet1 aMahajan, Shivangani1 aAhmed, Sumeer1 aBirajdar, Ram1 aVerma, Praveen, Kumar1 aSingh, Parvinder, Pal1 aSawant, Sanghapal, D. uhttps://library.ncl.res.in/content/sulfonyl-pyrazoles-sustainable-dual-functional-group-transfer-reagents-alcl3-promoted