01402nas a2200169   4500008004100000245009800041210006900139260000900208300001600217490000700233520076500240100002501005700002701030700002501057700002501082856012501107       2026                        eng d00aMetal-free sustainable synthesis of oximes and hydrazones from benzyl alcohol and benzylamine0 aMetalfree sustainable synthesis of oximes and hydrazones from be  cMAY   a28482-284870 v163 a<p>
	Herein, we report a one-pot synthesis of oximes and hydrazones via oxidative coupling of alcohols and amines with hydroxylamine hydrochloride and hydrazine, mediated by N-bromosuccinimide (NBS) and phenyliodine(iii) diacetate (PIDA), respectively. NBS mediates the benzyl alcohol oxidation, followed by coupling with hydroxylamine hydrochloride, as well as hydrazines, leading to the formation of oximes and hydrazones, respectively. Additionally, PIDA oxidizes benzylamine to the corresponding intermediate imine, which then reacts with hydroxylamine hydrochloride and hydrazine to form oximes and hydrazones, respectively. We have also demonstrated the effectiveness of this methodology through a gram-scale reaction and synthetic transformation.</p>
1 aDevgunde, Rupali, B.1 aRupanawar, Bapurao, D.1 aRupnavar, Prasad, B.1 aWaghmode, Suresh, B.  uhttps://library.ncl.res.in/content/metal-free-sustainable-synthesis-oximes-and-hydrazones-benzyl-alcohol-and-benzylamine