02426nas a2200253   4500008004100000245010400041210006900145260000800214300001200222490000700234520154800241653003601789653001001825653001701835653002201852653001801874653002101892100002601913700003201939700002501971700002501996700002302021856012802044       2026                        eng d00aHistory of maternal separation drives systemic aging-associated signatures in middle-aged male rats0 aHistory of maternal separation drives systemic agingassociated s  cMAY  a18096020 v203 a<p>
	Early adversity programs induce changes that can accelerate biological aging. Using the early stress model of maternal separation (MS), we assessed oxidative, metabolic, and biochemical consequences in serum derived from middle-aged male rats to investigate systemic correlates of physiological aging in MS animals. We noted significant increases in serum corticosterone in middle-aged MS male rats, accompanied by reduced serum levels of trophic factors, brain-derived neurotrophic factor (BDNF), and insulin-like growth factor-1 (IGF1). We also found increased oxidative stress markers, such as oxidized low-density lipoprotein (Ox-LDL) in MS animals, concomitant with reduced antioxidant enzyme activity of superoxide dismutase (SOD) and catalase. The serum lipid profile analysis revealed metabolic dysregulation with increased triglyceride, total cholesterol, and LDL levels. Furthermore, mass spectrometric analysis indicated a significant increase in advanced glycation end-product (AGE) modified serum albumin peptides in middle-aged MS male rats, accompanied by enhanced expression of the precursor for AGEs, methylglyoxal (MGO), and the soluble form of the receptor for AGEs (sRAGE). Collectively, these findings suggest that the early stress of MS evokes long-lasting systemic changes that persist into middle age and reflect glyco-oxidative damage, dyslipidemia, disrupted trophic factor signaling, and enhanced accumulation of AGEs, which could contribute mechanistically to cellular and physiological aging processes.</p>
10aadvanced glycation end-products10aaging10aearly stress10aMass spectrometry10amethylglyoxal10aOxidative stress1 aChaudhari, Pratik, R.1 aChaurasiya, Arvindkumar, H.1 aVaidya, Ashok, D. B.1 aKulkarni, Mahesh, J.1 aVaidya, Vidita, A.  uhttps://library.ncl.res.in/content/history-maternal-separation-drives-systemic-aging-associated-signatures-middle-aged-male