02157nas a2200265   4500008004100000022001400041245010100055210006900156260000900225300001100234490000700245520126900252653002601521653001601547653001901563653001801582653001801600100002301618700002201641700002101663700001901684700002601703700003701729856012501766       2025                        eng d  a2365-654900aSupramolecular self-assembly of glochidonol: a renewable triterpenoid from glochidion tomentosum0 aSupramolecular selfassembly of glochidonol a renewable triterpen  cAUG   ae012070 v103 a<p>
	Glochidonol a lupane pentacyclic (6-6-6-6-5) triterpenoid isolated from Glochidion tomentosum, exhibited exceptional gelation ability compared to the screened lupane- and oleanane-type triterpenoids. This study represents the first report on the self-assembly behavior of glochidonol in various liquids. The molecule self-assembled to form gels in all tested aromatic solvents, whereas no gelation was observed in water or phosphate buffer. The structural and physical properties of the self-assembled glochidonol were characterized using optical microscopy, scanning electron microscopy, atomic force microscopy, and Fourier-transform infrared spectroscopy. Additionally, the glochidonol-based self-assembled fibrillar network was utilized for the encapsulation of fluorescein isothiocyanate as a model drug, highlighting its potential for biomedical applications. A glochidonol-based gel loaded with doxorubicin exhibited sustained, diffusion-mediated drug release into PBS, accompanied by partial gel degradation. Fluorescence analysis confirmed release suggesting drug-gel interactions and diffusion. The glochidonol-based gel demonstrated sustained, diffusion-controlled doxorubicin release with partial degradation under physiological conditions.</p>
10aGlochidion tomentosum10aGlochidonol10aOrgano gelator10aSelf-assembly10aTriterpenoids1 aPatil, Harshal, S.1 aJagadeesh, K., S.1 aDinore, Jaysingh1 aSharanappa, P.1 aBaviskar, Ashwini, S.1 aThulasiram, Hirekodathakallu, V.  uhttps://library.ncl.res.in/content/supramolecular-self-assembly-glochidonol-renewable-triterpenoid-glochidion-tomentosum