01377nas a2200169 4500008004100000022001400041245018000055210006900235260000900304300001400313490000700327520066700334100002801001700002401029700002401053856013001077 2025 eng d a1523-706000aDiastereoselective synthesis of cyclic and spirocyclic quaternary carbons via iron-catalyzed ring contraction of cyclic ketones: a formal synthesis of perhydrohistrionicotoxin0 aDiastereoselective synthesis of cyclic and spirocyclic quaternar cAUG  a8798-88030 v273 a

The iron-catalyzed hydrogen atom transfer (HAT)-initiated Dowd-Beckwith rearrangement presents a new approach for synthesizing cyclic and spirocyclic quaternary carbons from readily available beta-keto esters and cyclic diketones with high yields. This reaction proceeds in a stereocontrolled manner, enabling the formation of synthetically valuable cyclic ketones with two contiguous stereocenters, including quaternary centers. This transformation introduces an innovative bond disconnection strategy for ring-contraction reactions. Additionally, a short formal synthesis of perhydrohistrionicotoxin was efficiently achieved using this methodology.

1 aSurvase, Vijayanand, U.1 aRokade, Avinash, D.1 aHandore, Kishor, L. uhttps://library.ncl.res.in/content/diastereoselective-synthesis-cyclic-and-spirocyclic-quaternary-carbons-iron-catalyzed-ring01502nas a2200169 4500008004100000022001400041245011400055210006900169260000900238300001600247490000700263520085900270100002301129700002401152700002401176856013201200 2025 eng d a0022-326300aSynthesis of Readily Modifiable Amides from Aldehydes via an Organocatalytic Approach Using a CTAB Surfactant0 aSynthesis of Readily Modifiable Amides from Aldehydes via an Org cAUG  a11288-113000 v903 a

A simple and efficient organocatalytic method has been developed to access ``readily modifiable'' amides, including bench-stable N-acyl saccharin and various activated amides, from aldehydes by using CTAB- t BuOOH. A wide range of aromatic and aliphatic acyl saccharin are obtained from their respective aldehydes with moderate to good yields. The approach can be similarly applied toward the formation of N-acyl imidazole, N-acyl benzimidazole, N-methoxy-N-methylamide (Weinreb amide), N-ethyl-N-phenylbenzamide, N-acyl morpholine, N-acyl valerolactam, and N-acyl caprolactam. These compounds are frequently applied as reagents in organic transformations, including acyl coupling, decarbonylative coupling, radical coupling, and coupling that is free from transition metals, enabling the synthesis of new C-C, C-N, C-O, C-S, C-P, and C-B bonds.

1 aAkhade, Akshay, M.1 aRokade, Avinash, D.1 aHandore, Kishor, L. uhttps://library.ncl.res.in/content/synthesis-readily-modifiable-amides-aldehydes-organocatalytic-approach-using-ctab-surfactant01156nas a2200169 4500008004100000022001400041245008700055210006900142260000800211300001400219490000700233520056700240100002400807700002100831700002400852856011000876 2026 eng d a1523-706000aPalladium-catalyzed annulation of acyl saccharins with norbornene via CO shuttling0 aPalladiumcatalyzed annulation of acyl saccharins with norbornene cAPR a4008-40130 v283 a

Palladium-catalyzed annulation presents a new approach for synthesizing indanones from readily available N-acyl saccharins and bicyclic alkenes with high yields. This reaction proceeds via cleavage of the C-H, C-C, and C-N bonds of the acyl saccharin and the rearrangement of the carbonyl moiety by decarbonylation and CO reinsertion. This transformation introduces an innovative bond disconnection strategy for annulation reactions via CO shuttling. Additionally, it can also be applied in the synthesis of the CDC7 inhibitor and ferrocene indanone.

1 aRokade, Avinash, D.1 aTeke, Nikhil, M.1 aHandore, Kishor, L. uhttps://library.ncl.res.in/content/palladium-catalyzed-annulation-acyl-saccharins-norbornene-co-shuttling