02083nas a2200241   4500008004100000022001400041245015700055210006900212260000900281300001200290490000700302520118800309653002201497653002301519653002101542653002801563653002301591100002501614700002401639700002701663700002601690856012501716       2025                        eng d  a1060-132500aBio-based poly(isobornyl acrylate)-b-(citronellyl methacrylate) block copolymers by PET-RAFT polymerization: thiol-ene modification and adhesion studies0 aBiobased polyisobornyl acrylatebcitronellyl methacrylate block c  cSEP   a728-7360 v623 a<p>
	In this study, poly(isobornyl acrylate)-b-poly(citronellyl methacrylate) (PIBA-b-PCMA) block copolymers were synthesized with controlled molecular weights and low dispersity using photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization of isobornyl acrylate (IBA) and citronellyl methacrylate (CMA), both terpene-derived monomers. A series of block copolymers was obtained by varying the chain length of PCMA block. Kinetics study of the polymerization of IBA and CMA using 4-cyano-(((dodecylthio)carbonothioyl)thio)pentanoic acid (CDTPA) as chain transfer agent showed a linear plot of ln[M]0/[M]t vs time indicating first order reaction. Distinct glass transition temperatures were observed for the individual blocks and enhanced thermal stability was seen with increasing PCMA content. Post-polymerization modification of the polymer was demonstrated using thiol-ene reaction with the vinyl group in the pendent citronellyl moiety. Adhesion performance, evaluated through lap shear test on aluminum substrates, showed that the block copolymers achieved peak shear strengths of 1.74 MPa at a 38:62 PIBA:PCMA mole ratio.</p>
10aadhesion strength10aBio-based polymers10ablock copolymers10aPET-RAFT polymerization10aThiol-ene reaction1 aHetkale, Pragati, M.1 aPurohit, Poorvi, M.1 aNair, Kiran, Sukumaran1 aAmbade, Ashootosh, V.  uhttps://library.ncl.res.in/content/bio-based-polyisobornyl-acrylate-b-citronellyl-methacrylate-block-copolymers-pet-raft02255nas a2200277   4500008004100000022001400041245012900055210006900184260000800253300001100261490000800272520131600280653001801596653001501614653001801629653002601647653001701673653001301690653001801703653002101721100002601742700002901768700002401797700002601821856013001847       2026                        eng d  a0021-899500aRedox- and pH-responsive block copolymer nanocarriers with dual drug conjugation through dynamic covalent and hydrogen bonds0 aRedox and pHresponsive block copolymer nanocarriers with dual dr  cMAR  ae702050 v1433 a<p>
	Loading of multiple drugs in a nanocarrier with high entrapment efficiency is important for combination therapy in cancer treatment. Here, a block copolymer comprising hydrophobic poly(epsilon-caprolactone) block with a defined number of pendent propargyl groups, polyethylene glycol monomethyl ether as a hydrophilic block, and a redox-responsive disulfide group at the block junction is synthesized using click chemistry and ring-opening polymerization (ROP). Benzaldehyde and thymine groups are introduced in the side chains for selective attachment of anti-cancer drugs, doxorubicin (DOX) and methotrexate (MTX), via the formation of pH-responsive imine linkage and hydrogen bonds, respectively. The drug-conjugated block copolymers are assembled into spherical micelles of &lt; 200 nm, and the preferential release of DOX and MTX in response to acidic pH and redox conditions is shown. At pH 5, DOX release was 59.5%, and MTX release was 40% compared to 13% and 12% at pH 7.4, whereas at pH 5 with 10 mM GSH, a DOX release of 81.5% was observed after 48 h. Cellular uptake of drug-conjugated micelles and their apoptosis compared to free DOX in the MDA-MB-231 breast cancer cells is demonstrated. Caveolae-mediated endocytosis was found to be the major pathway used by drug-loaded nanocarriers.</p>
10abiodegradable10acopolymers10aDOX-conjugate10adrug delivery systems10amethotrexate10amicelles10apH-responsive10aredox-responsive1 aAvhad, Shankarrao, V.1 aSurapaneni, Sai, Geetika1 aPurohit, Poorvi, M.1 aAmbade, Ashootosh, V.  uhttps://library.ncl.res.in/content/redox-and-ph-responsive-block-copolymer-nanocarriers-dual-drug-conjugation-through-dynamic