01092nas a2200229 4500008004100000022001400041245008200055210007000137260000800207300001400215490000700229520038200236653002000618653001200638653001200650653001400662653001000676100002400686700001900710700002600729856010700755 2025 eng d a0039-788100aSynthesis of isatins via oxone® /TBAI-mediated on-water oxidation of indoles0 aSynthesis of isatins via oxone® TBAImediated onwater oxidation o cMAY a1583-15910 v573 a

Isatins and their derivatives are important scaffolds in a wide range of pharmaceuticals, bioactive compounds, and functional materials. Herein we describe a new strategy for the synthesis of isatins from indoles via Oxone (R)/TBAI-mediated oxidative dearomatization of indoles in water. The strategy works well with a variety of N-protected indoles and azaindoles.

10adearomatization10aindoles10aisatins10aOxidation10aWater1 aKhajuria, Pratiksha1 aBag, Debojyoti1 aSawant, Sanghapal, D. uhttps://library.ncl.res.in/content/synthesis-isatins-oxone%C2%AE-tbai-mediated-water-oxidation-indoles