01071nas a2200181 4500008004100000022001400041245006200055210006200117260000800179300001400187490000700201520049600208100002500704700002500729700002000754700002700774856008800801 2025 eng d a0022-326300aAryl borane as a catalyst for dehydrative amide synthesis0 aAryl borane as a catalyst for dehydrative amide synthesis cJAN a2271-22770 v903 a

Tris(pentafluorophenyl)borane B(C6F5)(3)H2O is reported as a catalyst for dehydrative amidation of carboxylic acids and amines. This protocol is applicable across a wide range of >35 substrates, including aromatic and aliphatic amines and acids, resulting in amides in <= 92% yields. The scalability of the reaction up to 10 mmol, along with the synthesis of drugs such as ibuprofen amide, moclobemide, and phenacetin, demonstrates the industrial potential of our protocol.

1 aGavit, Amit, Vinayak1 aTalekar, Sanjana, S.1 aMane, Manoj, V.1 aSawant, Dinesh, Nanaji uhttps://library.ncl.res.in/content/aryl-borane-catalyst-dehydrative-amide-synthesis01705nas a2200229 4500008004100000022001400041245011200055210006900167260000800236490000800244520092700252653001201179653000701191653001301198653001001211653001401221100002501235700003101260700003001291700002701321856012701348 2025 eng d a1615-415000aDiboron reagents in modern reduction chemistry: a versatile tool for reduction of various functional groups0 aDiboron reagents in modern reduction chemistry a versatile tool  cOCT0 v3673 a

Reduction of various organic functionality including aldehyde, ketone, nitro, imine, and alkyne has gained noteworthy attention due to its vast application of products in organic transformation reactions. To attempt hydrogenation several approaches have been reported by using molecular hydrogen as a reducing source. Besides, this diboron (tetrahydroxy diboron, bispinacolato diboron, neoglycolato diboron) has shown a promising and alternative approach for the reduction of the reducible functional group without using any molecular hydrogen. The ligand-free reduction approach of commercially available diboron reduces the organic compound by using water or organic solvent and metal salt making it an attractive protocol in the recent era of reduction as well as hydrogenation. Herein, we provide an extensive and collective overview of the diboron-mediated reduction approach of various organic compounds.

10adiboron10aH210aH2O/MeOH10aMetal10areduction1 aGavit, Amit, Vinayak1 aDarandale, Nutan, Rajendra1 aSurange, Sarthak, Baburao1 aSawant, Dinesh, Nanaji uhttps://library.ncl.res.in/content/diboron-reagents-modern-reduction-chemistry-versatile-tool-reduction-various-functional