02143nas a2200241   4500008004100000022001400041245010300055210006900158260000800227300001200235490000700247520126500254653003301519653003501552653003001587653002901617100002801646700002301674700002601697700002401723700002301747856013101770       2025                        eng d  a1083-616000aConfined impinging jet reactor for high-throughput continuous flow mononitration of salicylic acid0 aConfined impinging jet reactor for highthroughput continuous flo  cJAN  a479-4890 v293 a<p>
	Novel approach is reported for highly efficient continuous mononitration of salicylic acid using confined impinging jet reactor (CIJR) with a vent. Initially, controlled semibatch reactions are optimized to achieve complete conversion and formation of mononitro products with very high selectivity for 5-nitrosalicylic acid (5-NSA). Further, the combination of computational fluid dynamics simulations and experiments is employed to optimize CIJR design and operating flow conditions, suitable to yield only mononitro products with excellent control over mixing, heat transfer, and liberation of fumes during continuous flow reaction. Detailed analysis of internal flow patterns, rate of heat generation, and concentration distribution inside the CIJR facilitated the optimization of present exothermic reaction in a safe manner. In less than a minute, complete salicylic acid (SA) conversion with good yield and better selectivity for 5-NSA is achieved using the CIJR. Safety and clogging issues are addressed effectively, even at a relatively lower mole ratio (1:5) of SA:acetic acid (AcOH). The present approach is quite scalable using the numbering-up strategy, with advantages viz. nonfouling, high throughput, and the small footprint of CIJR.</p>
10acomputational fluid dynamics10aconfined impinging jet reactor10ahigh-throughput synthesis10asalicylic acid nitration1 aKhan, Muzammilanwar, S.1 aShaikh, Tabrez, R.1 aKulkarni, Sphurti, P.1 aPatil, Abhishek, A.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/confined-impinging-jet-reactor-high-throughput-continuous-flow-mononitration-salicylic-acid