01393nas a2200193   4500008004100000022001400041245014200055210007300197260000800270300001400278490000700292520063200299100002300931700002400954700002600978700002601004700002201030856014701052       2025                        eng d  a0022-326300aDivergent access to α-carbonyl-α′-vinyl sulfoxonium ylides and polysubstituted furans from β-ketosulfoxonium ylides and ynone-esters0 aDivergent access to αcarbonylα′vinyl sulfoxonium ylides and poly  cAPR  a6186-62070 v903 a<p>
	Here, we describe the synthesis of novel alpha-carbonyl-alpha `-vinyl sulfoxonium ylides under ambient, catalyst-free, and additive-free conditions, demonstrating broad substrate scope and scalability using beta-ketosulfoxonium ylides and alpha-ynone-esters. Furthermore, these ylides serve as versatile intermediates for the synthesis of highly substituted furans via Br &amp; oslash;nsted acid (p-TsOH) catalysis at 130 degrees C. This approach offers key advantages, including wide substrate compatibility, divergent product formation from common precursors, gram-scale feasibility, and good to excellent yields.</p>
1 aIngale, Sudhir, R.1 aSahu, Manas, Ranjan1 aBorade, Balasaheb, R.1 aGamidi, Rama, Krishna1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/divergent-access-%CE%B1-carbonyl-%CE%B1%E2%80%B2-vinyl-sulfoxonium-ylides-and-polysubstituted-furans-%CE%B201374nas a2200169   4500008004100000022001400041245008100055210006900136260000800205300001400213490000700227520079000234100002401024700002301048700002201071856011101093       2025                        eng d  a1477-052000aTotal synthesis of linear lipodepsipeptide kavaratamide A and its C25-epimer0 aTotal synthesis of linear lipodepsipeptide kavaratamide A and it  cFEB  a1819-18220 v233 a<p>
	We report the stereoselective total synthesis of kavaratamide A, a linear lipodepsipeptide from the cyanobacterium Moorena bouillonii (collected in Kavaratti, India), and its unnatural C25-epimer. The convergent approach employs Keck asymmetric allylation to construct the chiral beta-hydroxy carboxylic acid fragment [(3S)-HDA; 3-hydroxydecanoic acid], while the peptide unit was assembled from l-Val, N-Me-l-Ala, (S)-Hiva, and (S)-iPr-O-Me-pyr using well-orchestrated coupling methods to prevent racemization. Modifications to the Keck allylation conditions enabled the synthesis of the C25-epimer with good yield. Cytotoxicity of kavaratamide A and C25-epi-kavaratamide A, assessed using the MTT assay, demonstrated moderate activity against HepG2 and PANC-1 cell lines.</p>
1 aSahu, Manas, Ranjan1 aIngale, Sudhir, R.1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/total-synthesis-linear-lipodepsipeptide-kavaratamide-and-its-c25-epimer