02051nas a2200253   4500008004100000022001400041245011600055210006900171260007700240300001400317490000700331520111700338653001601455653002601471653001401497653002101511653001301532653002601545100002101571700003301592700001401625700002801639856013001667       2014                        eng d  a1434-193X00aHeterogeneous foldamers from aliphatic-aromatic amino acid building blocks: current trends and future prospects0 aHeterogeneous foldamers from aliphaticaromatic amino acid buildi  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcDEC  a7763-77800 v463 a<p>Chemists' constant pursuit of understanding of the underlying principles of nature's most intricate phenomenon such as protein folding has led to the development of the field of foldamers. The emergence of diverse classes of unnatural amino acid building blocks has unleashed countless opportunities to design, develop and explore the structural and functional aspects of synthetic peptides. One current trend in foldamer chemistry is the heterofoldamer approach, which involves systematic stoichiometric variation of various natural/unnatural amino acid residues, leading to conformational ordering with intriguing structural architectures. In this regard, the incorporation of aromatic amino acids provides efficient structural rigidification and tunability to the molecular scaffolds, which can exhibit a range of secondary structural features. Recent times have witnessed an upsurge of foldamers featuring aliphatic-aromatic residues with diverse structural propensities. This review is an effort to cover this rapidly developing field of foldamer science and also to envisage its future perspectives.</p>10aAmino acids10aConformation analysis10aFoldamers10ahydrogen bonding10aPeptides10aStacking interactions1 aNair, Roshna, V.1 aVijayadas, Kuruppanthara, N.1 aRoy, Arup1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/heterogeneous-foldamers-aliphatic-aromatic-amino-acid-building-blocks-current-trends-and-0