02373nas a2200277   4500008004100000022001400041245014600055210006900201260007100270300001600341490000600357520136000363653001301723653002501736653001301761653001201774653002301786653001801809100002901827700002601856700001901882700001701901700002701918700002201945856012801967       2014                        eng d  a1944-824400aSol-gel assisted fabrication of collagen hydrolysate composite scaffold: a novel therapeutic alternative to the traditional collagen scaffold0 aSolgel assisted fabrication of collagen hydrolysate composite sc  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcSEP  a15015-150250 v63 a<p>Collagen is one of the most widely used biomaterial for various biomedical applications. In this Research Article, we present a novel approach of using collagen hydrolysate, smaller fragments of collagen, as an alternative to traditionally used collagen scaffold. Collagen hydrolysate composite scaffold (CHCS) was fabricated with sol-gel transition procedure using tetraethoxysilane as the silica precursor. CHCS exhibits porous morphology with pore sizes varying between 380 and 780 mu m. Incorporation of silica conferred CHCS with controlled biodegradation and better water uptake capacity. Notably, 3T3 fibroblast proliferation was seen to be significantly better under CHCS treatment when compared to treatment with collagen scaffold. Additionally, CHCS showed excellent antimicrobial activity against the wound pathogens Staphylococcus aureus, Bacillus subtilis, and Escherichia coli due to the inherited antimicrobial activity of collagen hydrolysate. In vivo wound healing experiments with full thickness excision wounds in rat model demonstrated that wounds treated with CHCS showed accelerated healing when compared to wounds treated with collagen scaffold. These findings indicate that the CHCS scaffold from collagen fragments would be an effective and affordable alternative to the traditionally used collagen structural biomaterials.</p>10acollagen10acollagen hydrolysate10ascaffold10asol-gel10atissue engineering10awound Healing1 aRamadass, Satiesh, Kumar1 aPerumal, Sathiamurthi1 aGopinath, Arun1 aNisal, Anuya1 aSubramanian, Saravanan1 aMadhan, Balaraman  uhttps://library.ncl.res.in/content/sol-gel-assisted-fabrication-collagen-hydrolysate-composite-scaffold-novel-therapeutic-002126nas a2200265   4500008004100000022001400041245009700055210006900152260000800221300001100229490000700240520127600247653002101523653001501544653001401559653001701573653001801590100002101608700002401629700001901653700001801672700001701690700002601707856012701733       2025                        eng d  a1616-518700aEngineered silk-dressing for acceleratedwound healing: biocompatibility and efficacy studies0 aEngineered silkdressing for acceleratedwound healing biocompatib  cNOV  ae003230 v253 a<p>
	Advanced wound care dressings are essential for improving clinical outcomes. The present study investigates the wound management potential of a unique dressing fabricated from silk proteins. The dressing was characterized for its physical and structural properties, including surface texture, porosity, fluid absorption capacity, and moisture vapor transmission rate. These parameters have been found to be critical for optimal wound healing. In vivo full thickness wound healing studies in a rat model validated the efficacy of the Silk-dressing compared to conventional cotton gauze and commercial polyurethane foam dressings. Histopathological analysis confirmed improved re-epithelialization, collagen deposition, angiogenesis, and formation of secondary follicles. Key advantages of Silk-dressing included non-adherence, absorption of exudate, maintenance of optimal moisture at wound site and acceleratedwound closure. Biocompatibility studies were also conducted in accordance with ISO 10993 guidelines, demonstrating no cytotoxicity, irritation, sensitization, or pyrogenicity. These findings highlight the potential of this uniquely designed Silk-dressing as a superior alternative for wound management, with a potential to improve clinical outcomes.</p>
10aBiocompatibility10abiopolymer10aISO 1099310aSilk protein10awound Healing1 aDeshpande, Rucha1 aPillai, Lakshmi, R.1 aSayyad, Raeesa1 aShukla, Swati1 aNisal, Anuya1 aVenugopalan, Premnath  uhttps://library.ncl.res.in/content/engineered-silk-dressing-acceleratedwound-healing-biocompatibility-and-efficacy-studies