00980nas a2200157 4500008004100000022001400041245007100055210006900126260000900195300001200204490000700216520044300223100003300666700002000699856010300719 2025 eng d a1477-052000aBase-mediated denitrative C3-alkylation of quinoxaline derivatives0 aBasemediated denitrative C3alkylation of quinoxaline derivatives cJAN  a303-3070 v233 a

We have developed a novel base-mediated method for the selective C3-alkylation of quinoxalin-2(1H)-one and N-protected quinoxalin-2(1H)-one using inexpensive, unactivated nitroalkanes. This approach tolerates a wide range of functional groups and supports the synthesis of various bioactive compounds. Gram-scale reactions demonstrate the scalability of the method. The proposed mechanism was validated by control experiments.

1 aPansare, Vaibhav, Ramachandr1 aBarsu, Nagaraju uhttps://library.ncl.res.in/content/base-mediated-denitrative-c3-alkylation-quinoxaline-derivatives02337nas a2200253 4500008004100000022001400041245006900055210006800124260000800192490000700200520155700207653001501764653001501779653002101794653001601815653001801831100002101849700003301870700001901903700002601922700001701948700002001965856009801985 2025 eng d a1864-563100aDepolymerization of waste polycarbonates to value-added products0 aDepolymerization of waste polycarbonates to valueadded products cJAN0 v183 a

Additive free aminolysis method developed for the depolymerization/upcycling of polycarbonates. We report here chemical recycling of polycarbonate under ambient conditions to get its monomer bisphenol A, monoaminocarbamate and biscarbamates in 1 : 2 : 1 ratio respectively. By employing the secondary amine as the aminating reagent, facilitates the depolymerization to work under additive/catalyst free conditions. The developed method deals with depolymerization of waste polycarbonates and works even with late-stage amine derivatives such as amoxapine and desloratadine which are drugs molecules known to treat neurotic disorders and allergies respectively. The reaction can be scaled up and works with similar efficacy which depicts the efficiency of the depolymerization of wasteend-of-life polycarbonate plastic waste. The biscarbamate and bisphenol-A was further subjected for the post functionalization to obtain amides and phenol in good yields. Developed additive/catalyst free aminolysis of waste polycarbonates to carbamates and monomer BPA at ambient conditions. Variety of secondary amines were screened including the late stage amine derivatives like amoxapine and desloratadine which delivered the expected products successfully. Later the developed methodology was even applied for the different end-of-life polycarbonates with the secondary amine and achieved the depolymerization without any obstacle. Further carried out the scale up reaction and derivatization of carbamates and BPA to amide and phenol synthesis. image

10aAminolysis10acarbamates10adepolymerization10aEnd-of-life10aPolycarbonate1 aPadhi, Ganeshdev1 aPansare, Vaibhav, Ramachandr1 aBajpai, Priyam1 aKrishna, Gamidi, Rama1 aVanka, Kumar1 aBarsu, Nagaraju uhttps://library.ncl.res.in/content/depolymerization-waste-polycarbonates-value-added-products