02862nas a2200205 4500008004100000245017400041210006900215260000800284300001200292490000700304520205400311100001702365700002502382700001902407700002502426700002202451700002802473700002402501856013102525 2024 eng d00aBlock copolymer self-assembly: exploitation of hydrogen bonding for nanoparticle morphology control via incorporation of triazine based comonomers by RAFT polymerization0 aBlock copolymer selfassembly exploitation of hydrogen bonding fo cOCT a24011290 v203 a

Synthesis of polymeric nanoparticles of controlled non-spherical morphology is of profound interest for a wide variety of potential applications. Self-assembly of amphiphilic diblock copolymers is an attractive bottom-up approach to prepare such nanoparticles. In the present work, RAFT polymerization is employed to synthesize a variety of poly(N,N-dimethylacrylamide)-b-poly[butyl acrylate-stat-GCB] copolymers, where GCB represents vinyl monomer containing triazine based Janus guanine-cytosine nucleobase motifs featuring multiple hydrogen bonding arrays. Hydrogen bonding between the hydrophobic blocks exert significant influence on the morphology of the resulting nanoparticles self-assembled in water. The Janus feature of the GCB moieties makes it possible to use a single polymer type in self-assembly, unlike previous work exploiting, e.g., thymine-containing polymer and adenine-containing polymer. Moreover, the strength of the hydrogen bonding interactions enables use of a low molar fraction of GCB units, thereby rendering it possible to use the present approach for copolymers based on common vinyl monomers for the development of advanced nanomaterials.

1 aHaque, Farah1 aThompson, Steven, W.1 aIshizuka, Fumi1 aKuchel, Rhiannon, P.1 aSingh, Dharmendra1 aSanjayan, Gangadhar, J.1 aZetterlund, Per, B. uhttps://library.ncl.res.in/content/block-copolymer-self-assembly-exploitation-hydrogen-bonding-nanoparticle-morphology-control00858nas a2200229 4500008004100000022001400041245013800055210006900193260000900262300001400271490000600285653002800291653001900319653002000338653002800358100002500386700001500411700002200426700002800448700002400476856012800500 2024 eng d a2637-610500aSynthesis and film formation of aqueous emulsion polymer latexes featuring hydrogen bonding via a janus guanine-cytosine base monomer0 aSynthesis and film formation of aqueous emulsion polymer latexes cMAY  a6495-65070 v610aEmulsion polymerization10aFilm formation10aHydrogenbonding10aSupramolecular networks1 aThompson, Steven, W.1 aLi, Joanna1 aSingh, Dharmendra1 aSanjayan, Gangadhar, J.1 aZetterlund, Per, B. uhttps://library.ncl.res.in/content/synthesis-and-film-formation-aqueous-emulsion-polymer-latexes-featuring-hydrogen-bonding02423nas a2200217 4500008004100000022001400041245014000055210006900195260000900264300001600273490000700289520161200296100001701908700002501925700001901950700003001969700002201999700002802021700002402049856013202073 2025 eng d a0024-929700aMorphology rearrangement by mixing of internally hydrogen-bonded nanoparticles comprising triazine-based amphiphilic diblock copolymers0 aMorphology rearrangement by mixing of internally hydrogenbonded  cNOV  a11611-116200 v583 a

The self-assembly of block copolymers holds significant potential for designing functional nanoparticles in materials science, nanomedicine, and nanotechnology. While the self-assembly of amphiphilic diblock copolymers is relatively well understood, the influence of specific supramolecular interactions, particularly hydrogen bonding, in directing their morphological behavior remains largely unexplored. In this study, it was demonstrated that nanoparticles self-assembled in water/DMSO (75/25 vol/vol; 2 mg/mL) comprising amphiphilic diblock copolymers with a small amount of triazine-based guanine-cytosine (GCB) motifs incorporated in the hydrophobic block can undergo spontaneous rearrangement into new morphologies on mixing. For example, mixing spheres with vesicles resulted in spontaneous transformation into worms (nanofibers), and this transformation was accelerated at elevated temperature. The hydrogen bonding motif features three complementary hydrogen bonding sites on either side of the nucleobase unit, thereby having a Janus character. Amphiphilic diblock copolymers comprising dimethyl acrylamide (hydrophilic segment) and n-butyl acrylate (hydrophobic segment) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with a variable content of acrylate monomer functionalized with the Boc-protected form of the GCB motif as part of the hydrophobic segment. The present work represents a completely new approach for controlling self-assembly processes, paving the way for the design of functional nanoparticles for a range of applications.

1 aHaque, Farah1 aThompson, Steven, W.1 aIshizuka, Fumi1 avan der Tol, Joost, J. B.1 aSingh, Dharmendra1 aSanjayan, Gangadhar, J.1 aZetterlund, Per, B. uhttps://library.ncl.res.in/content/morphology-rearrangement-mixing-internally-hydrogen-bonded-nanoparticles-comprising-triazine