02861nas a2200241 4500008004100000022001400041245016700055210006900222260000900291300001100300490000700311520196300318653002402281653003702305653001402342653004102356653001902397100001602416700002302432700002002455700002102475856012302496 2024 eng d a0091-328600aFabrication and evaluation of a spatially resolved fiber-optic probe for diffuse reflectance measurement for noninvasive diabetic foot ulcer diagnosis perspective0 aFabrication and evaluation of a spatially resolved fiberoptic pr cAPR  a0441030 v633 a

Timely diagnosis and monitoring of wound progression or healing are key to improving the long-term outcome of diabetic foot ulcers (DFU). Diffuse reflectance spectroscopy (DRS) has the potential to noninvasively diagnose the DFU in real time, as it detects changes in local blood volume fraction and oxygenation state level that occur when tissue becomes diseased or ulcerated. Since foot soles have a thicker epidermis and deeper blood vessels/capillaries than other parts of the body, a spatially resolved fiber-optic probe (SRFP) is needed to detect the optimal spatially resolved diffuse reflectance (SRDR) signal from the local site of the ulcer for DFU diagnosis. Therefore, herein, an SRFP consisting of a linear array of seven 400-mu m fibers with detector-source (D-S) fiber separation (rho) ranging from 0.8 to 4.8 mm was designed, fabricated, tested, and evaluated for SRDR measurement from a standard reflectance plate of barium sulfate (BaSO4) and foot sole of 27 healthy human subjects. The variation in SRDR spectra for each detector and source fiber pair measured with BaSO4 was found to be less than 1.6%. In-vivo measurements from the foot sole demonstrate that the fabricated probe has the ability to spatially resolve and distinguish the SRDR spectra from sites, namely, the fifth metatarsal, ball of great joint, calcaneum, and great toe. Experimentally and theoretically, the detector and source fiber pair of rho=1.6 and 2.4 mm were optimal for SRDR measurements from a human foot. To evaluate and validate the performance of SRFP in a context relevant to DFU diagnosis, further SRDS measurements were performed on the solid tissue phantoms that mimic the optical properties of the normal and diabetic foot sole, and their results are statistically found different. Preliminary results suggest that developed SRFP can be explored for DRS measurement from foot ulcer patients to confirm its potential clinical applicability.

10adiabetic foot ulcer10adiffuse reflectance spectroscopy10afoot sole10aspatially resolved fiber-optic probe10atissue phantom1 aKumar, Ajay1 aHattale, Gangadhar1 aPawar, Dnyandeo1 aKanawade, Rajesh uhttps://library.ncl.res.in/content/fabrication-and-evaluation-spatially-resolved-fiber-optic-probe-diffuse-reflectance00734nas a2200193 4500008004100000245012800041210006900169260000900238490000700247653002300254653001000277100001600287700002300303700001800326700002000344700002400364700002100388856013100409 2024 eng d00aNormal and diabetic foot sole skin mimicking tissue phantom fulfillment for spectroscopic-based DFU diagnostics perspective0 aNormal and diabetic foot sole skin mimicking tissue phantom fulf cJUN 0 v1410aOPTICAL-PROPERTIES10aSTATE1 aKumar, Ajay1 aHattale, Gangadhar1 aHinge, Sarika1 aKulkarni, Gauri1 aLate, Dattatray, J.1 aKanawade, Rajesh uhttps://library.ncl.res.in/content/normal-and-diabetic-foot-sole-skin-mimicking-tissue-phantom-fulfillment-spectroscopic-based02271nas a2200361 4500008004100000022001400041245016600055210006900221260000800290300001100298490000800309520108600317653000801403653002601411653002001437653002701457653003201484653002301516100001801539700001601557700001601573700001901589700002201608700002301630700001801653700001901671700001601690700001901706700001601725700001901741700002101760856012801781 2025 eng d a0360-319900aOptimisation of metallic bismuth nanoparticle supported Pt-Bi(x%)/C hybrid electrocatalyst for cost effective and efficient hydrogen production in alkaline media0 aOptimisation of metallic bismuth nanoparticle supported PtBixC h cAUG a1506990 v1613 a

The present study employed a simple mechanochemical method followed by 24-h ultrasonication to synthesize oxide-free metallic bismuth (Bi) nanoparticles. This was further used to synthesize a Pt-Bi(x%)/C (NC-x) hybrid electrocatalyst for the hydrogen evolution reaction in alkaline media. X-ray photoelectron spectroscopy and contact angle measurements reveal, Bi modifies the electronic structure and surface morphology of the Pt/C electrocatalyst, thus enhancing reaction kinetics and active site availability. The relative three-electrode study reveals that optimised NC-20 electrocatalyst reduces the overpotentials by 10.44 % and enhances the current density by 53 % compared to commercial Pt/C. The practical applicability of the NC-20 electrocatalyst was studied with the 13 cm2 single cell anion exchange membrane electrolyser. The catalyst demonstrates promising performance where the current density of NC-20//IrO2 relatively increases by 22.6 % compared to standard Pt/ C//IrO2, and shows continuous production and stable performance when monitored for 30 h.

10aAEM10aBismuth nanoparticles10aelectrocatalyst10aFull cell electrolysis10ahydrogen evolution reaction10awater electrolysis1 aDokhe, Revati1 aUgale, Atul1 aDube, Onkar1 aVarpe, Vaibhav1 aGalave, Chaitanya1 aHattale, Gangadhar1 aKadam, Rutuja1 aVirole, Vishal1 aKumar, Ajay1 aHusale, Sudhir1 aNatu, Varun1 aShevate, Rahul1 aKanawade, Rajesh uhttps://library.ncl.res.in/content/optimisation-metallic-bismuth-nanoparticle-supported-pt-bixc-hybrid-electrocatalyst-cost02813nas a2200301 4500008004100000245016300041210006900204260000800273300001200281490000600293520178700299653002402086653002102110653002102131653002102152653002402173100002302197700001802220700001902238700001702257700001702274700001602291700001902307700001702326700001802343700002102361856012902382 2026 eng d00aPhotoluminescence decay lifetime study of hydrothermally synthesized highly porous ruthenium-silica composite for optical dissolved oxygen sensing application0 aPhotoluminescence decay lifetime study of hydrothermally synthes cJAN a937-9490 v93 a

Pore size and surface area of photoluminescence (PL)-based transition metal composites play crucial roles in facilitating oxygen diffusion, thereby enhancing the response and sensitivity of optical dissolved oxygen (DO) sensors. In this study, we successfully applied the hydrothermal method to synthesize a porous ruthenium composite embedded in a silica matrix, demonstrating its effectiveness for optical DO sensing applications. The ruthenium-silica (Ru-Si) composites were synthesized using Ru(bpy)3 2+ and tetraethyl orthosilicate (TEOS) as precursors, with reaction temperatures ranging from 120 degrees C to 200 degrees C over a fixed duration of 4 h. The structural, morphological, and compositional characterization techniques confirmed the successful synthesis and evaluated the porosity, surface features, and chemical structure of the resulting composites. The optimized Ru-Si composite exhibited the highest porosity, characterized by a specific surface area of 996.78 m2 g- 1, and exhibited the highest decay lifetime of 8.14 mu s in deionized (DI) water, compared to other composites. Importantly, we demonstrate an excellent linear response of the synthesized Ru-Si composite to DO concentrations ranging from 2.58 to 11.16 mg L-1, with a Stern-Volmer constant of 0.12. Furthermore, a density functional theory study was conducted to investigate the electronic transitions and to elucidate the oxygen quenching mechanism of the excited Ru composite with molecular oxygen. The calculated photophysical parameters of the composite show good agreement with the experimental results. Preliminary results suggest that the synthesized Ru-Si with high pore size and surface area could be an efficient and effective composite for use in DO sensing applications.

10aHydrothermal method10aopticalDO sensor10aoxygen quenching10aphotoluminescent10aruthenium composite1 aHattale, Gangadhar1 aKadam, Rutuja1 aVirole, Vishal1 aPandya, Rinu1 aPaul, Aditya1 aKumar, Ajay1 aShevate, Rahul1 aVanka, Kumar1 aSaha, Avishek1 aKanawade, Rajesh uhttps://library.ncl.res.in/content/photoluminescence-decay-lifetime-study-hydrothermally-synthesized-highly-porous-ruthenium