01432nas a2200181   4500008004100000022001400041245013200055210006900187260000900256300001400265490000700279520074100286100002301027700002401050700002401074700002101098856013101119       2024                        eng d  a1523-706000aCatalytic cycloisomerization-oxidative cyclization reaction sequence of enyne diesters derived from 2-propargyloxyarylaldehydes0 aCatalytic cycloisomerizationoxidative cyclization reaction seque  cNOV   a9793-97980 v263 a<p>
	Enyne diesters derived from 2-propargyloxyarylaldehydes are converted into 2-oxopyranochromenes via In(OTf)3-catalyzed cycloisomerization and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated oxidative cyclization reaction sequence in one pot. The process possesses broad substrate scope and good functional group compatibility and generates various 4-(hetero)aryl-substituted 2-oxopyranochromenes in 32-79% yields (over two steps). 2-Oxopyranochromenes undergo selective decarboxylation under Krapcho conditions. When treated with aliphatic secondary amines in DMF, 2-oxopyranochromenes undergo decarboxylative amination at ambient temperature to generate 2-amino-substituted functionalized chromenes in good yields.</p>
1 aPrajapati, Karmdeo1 aSaini, Manoj, Kumar1 aGonnade, Rajesh, G.1 aBasak, Ashok, K.  uhttps://library.ncl.res.in/content/catalytic-cycloisomerization-oxidative-cyclization-reaction-sequence-enyne-diesters-derived