01672nas a2200265   4500008004100000022001400041245007400055210006900129260000900198300000700207490000800214520085900222653002801081653002301109653001601132653002401148653001101172653002001183653001801203100001801221700002301239700002101262700002101283856010201304       2024                        eng d  a0974-362600aEfficient one-pot process for synthesis of antiviral drug Ganciclovir0 aEfficient onepot process for synthesis of antiviral drug Gancicl  cSEP   a710 v1363 a<p>
	A regioselective novel one-pot synthesis of heterocyclic purine derivative antiviral agent Ganciclovir in which initially guanine is treated with acetic anhydride in the presence of iodine (5%) to get diacetyl guanine intermediate, which undergoes in situ N-alkylation with AMDP in presence of catalytic acidic Amberlite IR-120 to get N-alkylated intermediate and finally deacetylation to get pure regioselective Ganciclovir, which is commercially viable and eco-friendly.Graphical abstractWe developed one-pot synthesis of antiviral drug Ganciclovir. Initially, Guanine is treated with acetic anhydride and iodine to yield diacetyl guanine 3. This intermediate then reacted with AMDP in the presence of acidic Amberlite IR-120 to obtain compound 5. Finally, deacetylation yields Ganciclovir 1, a commercially viable and eco-friendly process.</p>
10aAcidic Amberlite IR-12010aacyclic nucleoside10aanti-herpes10acommercially viable10aiodine10aone-pot process10aregiospecific1 aSudrik, Vilas1 aKarpe, Dnyaneshwar1 aJadhav, Vrushali1 aLawande, Shamrao  uhttps://library.ncl.res.in/content/efficient-one-pot-process-synthesis-antiviral-drug-ganciclovir