01773nas a2200229   4500008004100000022001400041245019600055210006900251260000900320300001400329490000700343520089800350100002101248700002201269700002601291700002301317700001501340700001801355700001901373700002101392856013001413       2024                        eng d  a0022-326300a2-Pyridone-directed CuII-catalyzed general method of C(sp2)-H activation for C-S, C-Se, and C-N cross-coupling: easy access to aryl thioethers, selenide ethers, and sulfonamides and DFT study0 a2Pyridonedirected CuIIcatalyzed general method of Csp2H activati  cAPR   a6798-68120 v893 a<p>
	We have demonstrated N-substituted 2-pyridones as an N,O-directing group for selective C(sp(2))-H-activated thiolation, selenylation, and sulfonamidation of ortho C-H bonds of benzamides. This method utilizes a cost-effective Cu(II)-salt catalyst instead of precious metal catalysts, achieving high yields, including gram-scale synthesis and excellent functional group tolerance. We applied this protocol to access 30 different compounds with high yields, demonstrating thiolation of fluorine-substituted benzamides as well. Density functional theory (DFT) calculations support the mechanism, including acetate-supported concerted metalation deprotonation (CMD) steps and the unique role of dimethyl sulfoxide (DMSO) solvent. The facile synthesis of pharmaceutically important sulfonamides and other compounds highlights the method's potential in chemistry and medicinal chemistry.</p>
1 aPati, Tanmay, K.1 aMolla, Sabir, Ali1 aGhosh, Narendra, Nath1 aKundu, Mrinalkanti1 aAjarul, Sk1 aMaity, Pradip1 aKhamrai, Uttam1 aMaiti, Dilip, K.  uhttps://library.ncl.res.in/content/2-pyridone-directed-cuii-catalyzed-general-method-csp2-h-activation-c-s-c-se-and-c-n-cross