02411nas a2200265   4500008004100000022001400041245012700055210006900182260000900251300001400260490000600274520146900280653002201749653003301771653003801804653001801842653001701860653001701877100002701894700002001921700002701941700002601968700002701994856012402021       2024                        eng d  a2637-610500aNonedible thevetia peruviana oil for the synthesis of biobased thermosets and vitrimers with tunable mechanical properties0 aNonedible thevetia peruviana oil for the synthesis of biobased t  cFEB   a2695-27080 v63 a<p>
	Current attempts to replace fossil-derived materials with vegetable oils for polymer production mainly rely on edible oils. This approach raises sustainability concerns due to potential food security risks. This report introduces the first in-depth examination of Thevetia peruviana oil (TPO) epoxidation, an easily accessible nonedible vegetable oil, utilizing diverse acidic ion-exchange resins as catalysts. It is followed by the development of vitrimers based on epoxidized oil (ETPO) with various dicarboxylic acid hardeners. Amberlite IRC120H emerged as the most effective catalyst for the epoxidation of the oil, allowing for repeated catalyst reusability for up to five cycles. An impressive relative oxirane conversion of 98.9% was achieved after optimization. DSC analysis revealed that among the diacids, 2,2'-dithiodibenzoic acid (DTBZ) has the lowest activation energy with ETPO. Additionally, the ETPO-DTBZ-based thermosets displayed exceptional solvent resistance and thermal stability, indicative of a high degree of cross-linked networks within the system. Mechanical analyses revealed that all aliphatic hardeners resulted in soft materials, while DTBZ resulted in thermosets with tensile stress and modulus of 15 and 843 MPa, respectively. Consequently, DTBZ-ETPO thermosets were successfully recycled, repaired, and reshaped with minimal changes in the mechanical properties. The shape memory of the thermosets was also established.</p>
10abiobasedvitrimers10aenvironmental sustainability10aepoxidizedThevetial peruviana oil10anonedible oil10aOptimization10ashape memory1 aOlosho, Adebayo, Isaac1 aAlam, Md, Shafi1 aNair, Kiran, Sukumaran1 aAmbade, Ashootosh, V.1 aAdekola, Folahan, Amoo  uhttps://library.ncl.res.in/content/nonedible-thevetia-peruviana-oil-synthesis-biobased-thermosets-and-vitrimers-tunable02436nas a2200241   4500008004100000022001400041245016800055210006900223260000800292300001200300490000700312520154000319653001901859653002201878653001901900653001701919653001401936100003401950700002401984700002802008700002702036856013102063       2026                        eng d  a1060-132500aGreen synthesis of PLGA and fabrication of topotecan and thymoquinone dual anticancer drug loaded PLGA nanoparticles: a controlled release study for cancer therapy0 aGreen synthesis of PLGA and fabrication of topotecan and thymoqu  cMAR  a232-2460 v633 a<p>
	Cancer therapy is often hindered by poor solubility, low bioavailability, drug resistance, and tumor microenvironmental barriers associated with conventional chemotherapeutics. Polymeric nano-drug delivery systems offer a promising strategy to overcome these limitations, particularly for synergistic multi-drug delivery. In this study, a biodegradable and biocompatible PLGA copolymer (70:30, M-w approximate to 14,500) was synthesized by ring-opening polymerization using zinc proline complex as an initiator through a green route. The copolymer's potential for delivering topotecan (TPT), a water-soluble chemotherapeutic, thymoquinone (TQ), a poorly water-soluble chemotherapeutic, and their combination (TPT+TQ) for cancer treatment was investigated. These nanoparticles demonstrateda consistent particle size &lt; 200 nm high encapsulation efficiency along with desirable controlled-release attributes. Moreover, they exhibited specific release characteristics and cytotoxic effects against HeLa cells, achieving an IC50 value of 20.88 M for the combination therapy (TPT+TQ). Additionally, cytocompatibility testing on L929 fibroblasts confirmed over 98% cell viability for blank PLGA nanoparticles. Additionally, confocal imaging studies confirmed efficient cellular uptake and nuclear localization of the nanoparticles. Overall, the PLGA based dual drug loaded nanoparticles presents a promising approach for targeted, synergistic co-delivery, potentially improving efficacy and reducing toxicity in cancer therapy.</p>
10aBiodegradation10adual drug-loading10aPLGA copolymer10athymoquinone10aTopotecan1 aCheekuramelli, Naga, Srilatha1 aMuhammed, Hasin, N.1 aGarnaik, Baijayantimala1 aNair, Kiran, Sukumaran  uhttps://library.ncl.res.in/content/green-synthesis-plga-and-fabrication-topotecan-and-thymoquinone-dual-anticancer-drug-loaded