01358nas a2200217   4500008004100000022001400041245010700055210006900162260011000231300001200341490000600353520049100359100002200850700002400872700002400896700002400920700002600944700001800970700002400988856012801012       2012                        eng d  a2040-250300aSynthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues0 aSynthesis and antifungal activity of 15disubstituted123triazole   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a484-4880 v33 a<p>Fluconazole based novel mimics containing 1,5-disubstituted 1,2,3-triazoles were synthesized by using Ru catalysed 1,3 dipolar cycloaddition. All the newly synthesized compounds and pure enantiomers were more potent than fluconazole against Candida albicans. Docking of 9A and 9B showed different conformation in the active site of Cyp51 of Candida albicans. The more active compounds 2 and 2A did not exhibit any toxicity up to 3.12 mu g mL(-1) against mammalian cell line L929.</p>1 aPore, Vandana, S.1 aJagtap, Manisha, A.1 aAgalave, Sandip, G.1 aPandey, Atindra, K.1 aSiddiqi, Mohammad, I.1 aKumar, Vikash1 aShukla, Praveen, K.  uhttps://library.ncl.res.in/content/synthesis-and-antifungal-activity-15-disubstituted-123-triazole-containing-fluconazole-001413nas a2200205   4500008004100000022001400041245005400055210005400109260011000163300001400273490000700287520069000294100002200984700002401006700002101030700002401051700001801075700002601093856008801119       2015                        eng d  a1477-052000aDesign and synthesis of new fluconazole analogues0 aDesign and synthesis of new fluconazole analogues  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a6551-65610 v133 a<p>We have synthesized new fluconazole analogues containing two different 1,2,3-triazole units in the side chain. The synthesis of new amide analogues using a variety of acids is also described. All the compounds showed very good antifungal activity. A hemolysis study of the most active compounds 6e and 13j showed that both compounds did not cause any hemolysis at the dilutions tested. These compounds did not exhibit any toxicity to L929 cells at MIC and lower concentrations. In the docking study, the overall binding mode of 6e and 13j appeared to be reasonable and provided a good insight into the structural basis of inhibition of Candida albicans Cyp51 by these compounds.</p>1 aPore, Vandana, S.1 aAgalave, Sandip, G.1 aSingh, Pratiksha1 aShukla, Praveen, K.1 aKumar, Vikash1 aSiddiqi, Mohammad, I.  uhttps://library.ncl.res.in/content/design-and-synthesis-new-fluconazole-analogues-001785nas a2200193   4500008004100000245008000041210006900121260000800190300001200198490000600210520113400216100002301350700002601373700001801399700001701417700002401434700002101458856011201479       2017                        eng d00aHigh-level supercapacitive performance of chemically reduced graphene oxide0 aHighlevel supercapacitive performance of chemically reduced grap  cNOV  a846-8600 v33 aReduction of graphene oxide (GO) is an important process because it holds promise for the production of reduced graphene oxide (rGO) with physicochemical properties similar to those of pristine graphene. In conventional chemical reduction, strong reducing agents, such as sodium borohydride and hydrazine, cannot be recycled. Also, fast reaction kinetics bring an imbalance in the desirable properties of rGO. Here, we present one-pot chemical reduction of GO in aqueous medium by an unconventional mild reducing agent (FeCl2/HCl) where rGOis isolated as the precipitate and the reducing agent is recycled upon simple treatment of the filtrate with HCl. The fabricated all-solid-state supercapacitors of as-synthesized rGO exhibited significantly higher specific capacitance than those obtained with rGO derived from conventional reducing agents. The cycling stability of the all-solid-state supercapacitor (> 80% retention of capacitance beyond 100,000 continued cycles) and its flexibility (> 500 bending cycles) were remarkable. Use of commercially available organic electrolyte further boosted the supercapacitor performance.1 aJha, Plawan, Kumar1 aSingh, Santosh, Kumar1 aKumar, Vikash1 aRana, Shammi1 aKurungot, Sreekumar1 aBallav, Nirmalya  uhttps://library.ncl.res.in/content/high-level-supercapacitive-performance-chemically-reduced-graphene-oxide02382nas a2200241   4500008004100000022001400041245016300055210006900218260000800287300001200295490000800307520150800315100002301823700002401846700001701870700001801887700002701905700001901932700001701951700002401968700002101992856012702013       2019                        eng d  a0008-622300aIn-situ generated Mn3O4-reduced graphene oxide nanocomposite for oxygen reduction reaction and isolated reduced graphene oxide for supercapacitor applications0 aInsitu generated Mn3O4reduced graphene oxide nanocomposite for o  cDEC  a285-2910 v1543 a<p>We have generated in situ nanocomposite of Mn3O4 and reduced graphene oxide (rGO) upon employing wet-chemical reduction of graphene oxide (GO) by Mn(II) salt as mild-reducing agent for the first time and examined the oxygen reduction reaction (ORR) activity in 0.1 M KOH electrolyte. The half-wave potential (E-1/2) of the nanocomposite catalyst (20% Mn3O4-rGO/C) was found to be around -0.153 V which is only similar to 87 mV negative from the commercially available catalyst (20% Pt/C). Remarkably, after 5000 linear sweep voltammetry cycles the E-1/2 shifted marginally by 20 mV; and the number of electrons transferred during ORR was estimated to be close to 4. Such an efficient electrocatalytic performance of the nanocomposite was primarily attributed to the synergistic interaction between Mn3O4 and rGO. The fabricated all-solid-state supercapacitor of rGO (extracted from the nanocomposite) in aqueous polyvinyl alcohol-sulfuric acid (PVA-H2SO4) gel polymer electrolyte (GPE) showed C-s value of similar to 310 F/g at a current density of 1 A/g along with long durability (10,000 charge-discharge cycles). All-solid-state flexible rGO supercapacitor exhibited high-flexibility and excellent durability (30,000 cycles with 100% retention of C-s). Our results provide an enormous opportunity in designing transition metal oxides decorated semiconducting reduced graphene oxide nanocomposite platforms for various electrochemical applications. (C) 2019 Elsevier Ltd. All rights reserved.</p>
1 aJha, Plawan, Kumar1 aKashyap, Varchaswal1 aGupta, Kriti1 aKumar, Vikash1 aDebnath, Anil, Krishna1 aRoy, Debashree1 aRana, Shammi1 aKurungot, Sreekumar1 aBallav, Nirmalya  uhttps://library.ncl.res.in/content/situ-generated-mn3o4-reduced-graphene-oxide-nanocomposite-oxygen-reduction-reaction-and