01443nas a2200157   4500008004100000022001400041245014800055210006900203260000900272300001600281490000600297520080300303100002401106700002601130856012901156       2024                        eng d  a2470-134300aC-H functionalization of imidazo[1,5-a]pyridines: a metal-free approach for methylene insertion to access C(sp2)-C(sp3)-H-C(sp2) bond formation0 aCH functionalization of imidazo15apyridines a metalfree approach  cDEC   a49071-490800 v93 a<p>
	Formaldehyde has been used as a solvent and a source of carbon to insert a methylene group for bridging two imidazo[1,5-a]pyridine molecules without using any metal catalysis. This strategy has been extended on other alkyl-, aryl-, and heteroaryl aldehydes as well. This C(sp2)-C(sp3)-H-C(sp2) bond forming reaction proceeds via C(sp2)H functionalization of imidazo[1,5-a]pyridine and was applied on a wide range of substrates offering moderate to good yields of methylene-bridged/inserted bis-imidazo[1,5-a]pyridines. Most importantly, as an application, the bis-heteroarene product has been demonstrated as a ligand. The ligand-like behavior of bis-imidazo[1,5-a]pyridines has been demonstrated as an extension of current methodology. This reaction works well at the gram scale level.</p>
1 aMahajan, Shivangani1 aSawant, Sanghapal, D.  uhttps://library.ncl.res.in/content/c-h-functionalization-imidazo15-apyridines-metal-free-approach-methylene-insertion-access01077nas a2200157   4500008004100000022001400041245013300055210007000188260000900258300001400267490000700281520045100288100001800739700002600757856013600783       2026                        eng d  a1144-054600aCu(ii)/I2 mediated synthesis of α-keto esters via C(sp2)-C(sp) bond cleavage of 1,2-alkynediones followed by C-O bond formation0 aCuiiI2 mediated synthesis of αketo esters via Csp2Csp bond cleav  cMAR   a5076-50800 v503 a<p>
	Herein, we disclose an efficient method for the synthesis of alpha-keto esters through a copper(ii)/iodine-mediated reaction. The transformation involves the selective cleavage of the C(sp2)-C(sp) bond of 1,2-alkynediones, which is subsequently followed by C-O bond formation with alcohols. This protocol offers a broad substrate scope, accommodating a wide range of substrates to furnish the desired alpha-keto esters in good yields.</p>
1 aNaveed, Abdul1 aSawant, Sanghapal, D.  uhttps://library.ncl.res.in/content/cuiii2-mediated-synthesis-%CE%B1-keto-esters-csp2-csp-bond-cleavage-12-alkynediones-followed-c-o