01777nas a2200241   4500008004100000022001400041245010600055210006900161260011000230300001400340490000700354520084200361100002601203700001901229700001901248700001701267700002401284700002601308700002301334700002601357700002501383856012701408       2015                        eng d  a1144-054600aSynthesis, DNA interaction and anticancer activity of 2-anthryl substituted benzimidazole derivatives0 aSynthesis DNA interaction and anticancer activity of 2anthryl su  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a4882-48900 v393 a<p>2-Anthryl benzimidazole derivatives (5-7) with hydrogen, carboxyl and benzoyl substituents at the 5th position have been synthesized using a silica supported periodic acid catalyst. The DNA cleavage activity of 5-7 was studied in the presence of light using pBR322 plasmid DNA and was shown to vary with substitution at the 5th position of benzimidazole derivatives. DNA binding studies using ethidium bromide displacement assay demonstrated the non-intercalative binding mode of 5-7. The anticancer activity of these target molecules was tested against MCF-7 and HL-60 cell lines, and they exhibited remarkable activity in the micromolar range. Cellular uptake and morphological changes were confirmed by fluorescence and confocal microscopy. A molecular docking study was carried out to explore the DNA binding mechanism of 5-7.</p>1 aSontakke, Vyankat, A.1 aKate, Anup, N.1 aGhosh, Sougata1 aMore, Piyush1 aGonnade, Rajesh, G.1 aKumbhar, Navanath, M.1 aKumbhar, Anupa, A.1 aChopade, Balu, Ananda1 aShinde, Vaishali, S.  uhttps://library.ncl.res.in/content/synthesis-dna-interaction-and-anticancer-activity-2-anthryl-substituted-benzimidazole-0