02789nas a2200217 4500008004100000022001400041245014400055210006900199260007100268300001200339490000700351520192500358100002102283700002302304700002302327700002102350700002602371700002402397700002602421856012402447 2011 eng d a0020-166900aSynthesis, electronic structure, DNA and protein binding, DNA cleavage, and anticancer activity of fluorophore-labeled copper(II) complexes0 aSynthesis electronic structure DNA and protein binding DNA cleav a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJAN a545-5580 v503 a

Two mononuclear fluorophore-labeled copper(II) complexes [Cu(nip)(acac)](+) (2) and [Cu(nip)(2)](2+) (3), where fluorophore is 2-(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (nip) (1) and acac is acetylacetone, have been synthesized aid characterized by various techniques. The ligand 1 and complex 2 are structurally characterized by single-crystal X-ray diffraction. The coordination geometries around the copper are square planar in solid as well as solution state as evidenced by electron paramagnetic resonance (EPR) spectroscopy. The density functional calculations carried out on 1-3 have shown that electron-rich regions in the highest occupied orbital are localized on the naphthalene end partly on the phenanthroline moiety. Both complexes 2 and 3 in dimethyl sulfoxide (DMSO) exhibit near square planar structure around the metal ion in their ground state. Time-dependent density functional theory (TD-DFT) calculations reveal that Cu(II) ion in complex 2 shows tetrahedral coordination around the metal while 3 retains its square planar geometry in the lowest excited state. The interaction of complexes with calf-thymus DNA (CT DNA) has been explored by using absorption, emission, thermal denaturation, and viscosity studies, and the intercalating mode of DNA binding has been proposed. The complexes cleave DNA oxidatively without any exogenous additives. The protein binding ability has been monitored by quenching of tryptophan emission in the presence of complexes using bovine serum albumin (BSA) as model protein. The compounds showed dynamic quenching behavior. Further, the anticancer activity of the complexes on MCF-7 (human breast cancer), HeLa (human cervical cancer), HL-60 (human promyelocytic leukemia), and MCF-12A (normal epithelial) cell lines has been studied. It has been observed that 3 exhibits higher cytotoxicity than 2, and the cells undergo apoptotic cell death.

1 aBhat, Satish, S.1 aKumbhar, Anupa, A.1 aHeptullah, Hussain1 aKhan, Ayesha, A.1 aGobre, Vivekanand, V.1 aGejji, Shridhar, P.1 aPuranik, Vedavati, G. uhttps://library.ncl.res.in/content/synthesis-electronic-structure-dna-and-protein-binding-dna-cleavage-and-anticancer-001777nas a2200241 4500008004100000022001400041245010600055210006900161260011000230300001400340490000700354520084200361100002601203700001901229700001901248700001701267700002401284700002601308700002301334700002601357700002501383856012701408 2015 eng d a1144-054600aSynthesis, DNA interaction and anticancer activity of 2-anthryl substituted benzimidazole derivatives0 aSynthesis DNA interaction and anticancer activity of 2anthryl su aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR a4882-48900 v393 a

2-Anthryl benzimidazole derivatives (5-7) with hydrogen, carboxyl and benzoyl substituents at the 5th position have been synthesized using a silica supported periodic acid catalyst. The DNA cleavage activity of 5-7 was studied in the presence of light using pBR322 plasmid DNA and was shown to vary with substitution at the 5th position of benzimidazole derivatives. DNA binding studies using ethidium bromide displacement assay demonstrated the non-intercalative binding mode of 5-7. The anticancer activity of these target molecules was tested against MCF-7 and HL-60 cell lines, and they exhibited remarkable activity in the micromolar range. Cellular uptake and morphological changes were confirmed by fluorescence and confocal microscopy. A molecular docking study was carried out to explore the DNA binding mechanism of 5-7.

1 aSontakke, Vyankat, A.1 aKate, Anup, N.1 aGhosh, Sougata1 aMore, Piyush1 aGonnade, Rajesh, G.1 aKumbhar, Navanath, M.1 aKumbhar, Anupa, A.1 aChopade, Balu, Ananda1 aShinde, Vaishali, S. uhttps://library.ncl.res.in/content/synthesis-dna-interaction-and-anticancer-activity-2-anthryl-substituted-benzimidazole-001334nas a2200253 4500008004100000022001400041245011600055210006900171260000800240300001200248490000700260520048500267653002500752653002200777653002300799653001000822653001300832653002700845100001700872700001700889700002500906700002300931856012600954 2022 eng d a1074-154200aSynthesis, characterization and single crystal x-ray structures of trifluroacetylacetonate copper(ii) complexes0 aSynthesis characterization and single crystal xray structures of cDEC a525-5330 v523 a

{Three Cu(II) complexes of 1,1,1-trifluoroacetylacetonate, viz. [Cu(TFACAC)(2)(MeOH)] (1), [Cu(TFACAC)(2)(py)] (2) and [Cu(TFACAC)(2)(DABCO)] (3) were synthesized and characterized by elemental analysis, IR, UV-Visible spectroscopy and cyclic voltammetry. Structures of complexes 1-3 were established by single crystal X-ray diffraction wherein 1 and 2 adapt square pyramidal geometry. Complex 1 crystallizes in triclinic space group P-(1), with a = 8.5059(6) angstrom

10aCopper(II) complexes10acrystal structure10acyclic voltammetry10aDABCO10aPyridine10aTrifluoroacetylacetone1 aKumari, Neha1 aBahadur, Vir1 aButcher, Raymond, J.1 aKumbhar, Anupa, A. uhttps://library.ncl.res.in/content/synthesis-characterization-and-single-crystal-x-ray-structures-trifluroacetylacetonate