02394nas a2200265   4500008004100000022001400041245016000055210006900215260000800284490000700292520144100299653002401740653001401764653003601778653001801814653001801832100002201850700001601872700001901888700002201907700002101929700002601950700002501976856012702001       2023                        eng d  a1616-518700aSelf-assembled amino acid microstructures as biocompatible physically unclonable functions (BPUFs) for authentication of therapeutically relevant hydrogels0 aSelfassembled amino acid microstructures as biocompatible physic  cNOV0 v233 a<p>
	Counterfeited biomedical products result in significant economic losses and pose a public health hazard for over a million people yearly. Hydrogels, a class of biomedical products, are being investigated as alternatives to conventional biomedical products and are equally susceptible to counterfeiting. Here, a biocompatible, physically unclonable function (BPUF) to verify the authenticity of therapeutically relevant hydrogels are developed. The principle of BPUF relies on the self-assembly of tyrosine into fibril-like structures which are incorporated into therapeutically relevant hydrogels resulting in their random dispersion. This unclonable arrangement leads to distinctive optical micrographs captured using an optical microscope. These optical micrographs are transformed into a unique security code through cryptographic techniques which are then used to authenticate the hydrogel. The temporal stability of the BPUFs are demonstrated and additionally, exploit the dissolution propensity of the structures upon exposure to an adulterant to identify the tampering of the hydrogel. Finally, a platform to demonstrate the translational potential of this technology in validating and detecting tampering of therapeutically relevant hydrogels is developed. The potential of BPUFs to combat hydrogel counterfeiting is exemplified by its simplicity in production, ease of use, biocompatibility, and cost-effectiveness.</p>
10aanti-counterfeiting10ahydrogels10aphysically unclonable functions10aSelf-assembly10atranslational1 aAkavaram, Vishwas1 aKumar, Kush1 aSriram, Shreya1 aNarra, Saisrinath1 aKumawat, Akshant1 aMeena, Santosh, Kumar1 aPushpavanam, Karthik  uhttps://library.ncl.res.in/content/self-assembled-amino-acid-microstructures-biocompatible-physically-unclonable-functions