01663nas a2200253   4500008004100000022001400041245015600055210006900211260010300280300001200383490000700395520063000402653002501032653004301057653001701100653002901117653001901146100002701165700002201192700002001214700001801234700002801252856012901280       2013                        eng d  a1631-074800aDiethylamine: a smart organocatalyst in eco-safe and diastereoselective synthesis of medicinally privileged 2-amino-4H-chromenes at ambient temperature0 aDiethylamine a smart organocatalyst in ecosafe and diastereosele  a23 RUE LINOIS, 75724 PARIS, FRANCEbELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERcAUG  a689-6950 v163 a<p>Diethylamine has been demonstrated to be an efficient organocatalyst in the diastereoselective synthesis of Bcl-2 protein antagonist (HA-14-1) and of its structural analogues by one-pot condensation between salicylaldehyde and three different C-H acids, viz, ethyl cyanoacetate, phenylsulfonyl acetonitrile, and malononitrile. Easy commercial availability of the catalyst at extremely low cost and avoidance of conventional work-up as well as purification procedures qualifies this scalable protocol for a ``near-ideal synthesis''. (c) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.</p>10a2-amino-4H-chromenes10aActive methylene compounds (C-H acids)10adiethylamine10amulticomponent reactions10aorganocatalyst1 aKulkarni, Makarand, A.1 aPandit, Kapil, S.1 aDesai, Uday, V.1 aLad, Uday, P.1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/diethylamine-smart-organocatalyst-eco-safe-and-diastereoselective-synthesis-medicinally-001472nas a2200265   4500008004100000022001400041245015100055210006900206260009200275300001200367490000600379520044600385653002200831653001700853653002000870653002900890653001900919653001500938100002000953700002700973700002201000700002501022700002801047856013101075       2014                        eng d  a1751-825300aSimple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature0 aSimple economical and environmentally benign protocol for the sy  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcJUN  a228-2350 v73 a<p>A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for ``green synthesis.''</p>10a5-dicarbonitriles10adiethylamine10agreen chemistry10amulticomponent reactions10aorganocatalyst10apyridine-31 aDesai, Uday, V.1 aKulkarni, Makarand, A.1 aPandit, Kapil, S.1 aKulkarni, Aparna, M.1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/simple-economical-and-environmentally-benign-protocol-synthesis-2-amino-35-dicarbonitrile-601595nas a2200217   4500008004100000022001400041245019500055210006900250300001400319520069500333653002401028653003001052653002001082653001901102100002701121700002501148700002601173700002701199700002901226856012201255       2023                        eng d  a1551-700400aCyclohexylamine -an efficient organocatalyst for the synthesis of 2-amino-4H-chromene derivatives by multicomponent reactions of salicylaldehydes, active methylene compounds and nitroalkanes0 aCyclohexylamine an efficient organocatalyst for the synthesis of  a2023121183 a<p>
	Cyclohexylamine was found to be an efficient organocatalyst for the synthesis of structurally diverse 2-amino4H-chromenes by multicomponent reaction of (substituted) salicylaldehydes, active methylene compounds and nitroalkanes at ambient temperature and under solvent-free conditions. The synthesis of a variety of 2amino-4H-chromenes was achieved using the reaction of (substituted) salicylaldehydes with two different C-H acids. The present protocol, which employed commercially available cyclohexylamine as an organocatalyst, offered the advantages of operational simplicity and avoidance of conventional purification methods and the obtained products were essentially pure.</p>
10a2-Amino-4H-chromene10aactive methylene compound10acyclohexylamine10aorganocatalyst1 aMitragotri, Satish, D.1 aKhyadage, Poonam, H.1 aChorghade, Diksha, S.1 aKulkarni, Makarand, A.1 aWadagaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/cyclohexylamine-efficient-organocatalyst-synthesis-2-amino-4h-chromene-derivatives