02258nas a2200265 4500008004100000022001400041245016900055210006900224260000900293300001200302490000700314520130000321653002001621653002701641653002401668653002201692100002301714700002001737700002301757700002201780700002201802700001901824700002301843856012601866 2024 eng d a1040-663800aSynthesis and antimicrobial evaluation of novel 2'-aryl-4-aryl-2,4'-Bisthiazole and 2'-aryl-4-Pyridyl-2,4'-bisthiazole derivatives as potential antibacterial agents0 aSynthesis and antimicrobial evaluation of novel 2aryl4aryl24Bist cFEB  a773-7870 v443 a

In continuation of our research work to explore bisthiazole derivatives as potential antimicrobial agents, herein we reported the synthesis of a series of novel 2'-aryl-4-aryl-2,4'-bisthiazole (7a-t) and 2'-aryl-4-pyridyl-2,4'-bisthiazole (9a-l) by cyclocondensation of 2-aryl thiazole-4-carbothioamide 5a-d with 2-bromo-1-arylethanone (6a-e) and bromo-1-(pyridin-2/3/4-yl)ethanone (8a-c), respectively. These novel candidates were evaluated in vitro for their antibacterial potential against four pathogenic bacteria, Escherichia coli (NCIM 2576), Pseudomonas flurescence (NCIM 2059), Staphylococcus aureus (NCIM 2602), and Bacillus subtilis (NCIM 2162). The synthesized compounds were also screened for their in vitro antifungal activity against Candida albicans (NCIM 3100). Among them, compounds 7b, 9d, 9 g, 9i, and 9 l exhibited excellent antibacterial activity with MIC 2.1 to 12.3 mu g/mL against all tested strains. Most of the compounds reported moderate antifungal activity. The pyridine ring-substituted bisthiazole reported good to excellent antibacterial activity as compared to phenyl ring-substituted bisthiazole. The potential antibacterial activity suggested that bisthiazole derivatives could assist in the development of lead compounds to treat microbial infections.

10a24'-bisthiazole10aantibacterial activity10aAntifungal activity10acyclocondensation1 aNalawade, Jitendra1 aShinde, Abhijit1 aAbhale, Yogita, K.1 aNandurkar, Yogesh1 aBobade, Vivek, D.1 aSarkar, Dhiman1 aMhaske, Pravin, C. uhttps://library.ncl.res.in/content/synthesis-and-antimicrobial-evaluation-novel-2-aryl-4-aryl-24-bisthiazole-and-2-aryl-4