02105nas a2200265   4500008004100000022001400041245015200055210006900207260000900276490000800285520115100293653002601444653002201470653001701492653001401509100002701523700002101550700002401571700002501595700002101620700002101641700002101662700002501683856013101708       2023                        eng d  a0223-523400aSynthesis of novel rhodamine type anthrone Spiro-lactam (ASL) analogues and evaluation of antiviral activity against dengue and chikungunya viruses0 aSynthesis of novel rhodamine type anthrone Spirolactam ASL analo  cDEC 0 v2613 a<p>
	A series of Rhodamine type Anthrone-Spirolactam (ASL) derivatives Benzylimin-Anthrone-Spirolactam (ASL-1 to ASL-10) and Benzamide-Anthrone-Spirolactam (ASL-11 and ASL-12) were synthesized via a simple condensation reaction between Anthrone Spiro-lactamine (2) and various aromatic aldehyde and acyl chlorides respectively. Since rhodamine-based compounds were reported to have antiviral activity, the ASL derivatives were examined for in vitro antiviral activity against dengue and chikungunya viruses. Among all the analogues, ASL-3, ASL-6, ASL-7, ASL-8, ASL-9 and ASL-10 were the most potent against dengue virus (DENV) and exerted around one log reduction in virus titre under post -treatment conditions. At the same time ASL-3 was effective under cotreatment conditions. Two analogues ASL-6 and ASL-12 exerted anti-chikungunya virus (CHIKV) activity under post -treatment conditions. In silico docking studies revealed that the ASL derivatives interacted with the proteins of DENV and CHIKV. Together, the results suggest the anti-DENV and CHIKV activity of ASL derivatives which may be exploited further for therapeutic purposes.</p>
10aAnthrone Spiro-lactam10aChikungunya virus10adengue virus10aRhodamine1 aDarole, Ratanamala, S.1 aBagad, Pooja, K.1 aGonnade, Rajesh, G.1 aAlagarasu, Kalichamy1 aPunekar, Madhura1 aShukla, Shridhar1 aParashar, Deepti1 aSenthilkumar, Beeran  uhttps://library.ncl.res.in/content/synthesis-novel-rhodamine-type-anthrone-spiro-lactam-asl-analogues-and-evaluation-antiviral