02916nas a2200301   4500008004100000022001400041245015000055210006900205260000800274300001400282490000600296520186400302653003302166653001802199653002702217653001302244653001802257653002102275100002002296700002802316700001602344700002502360700002302385700002902408700002702437700002602464856012402490       2026                        eng d  a2637-610500apH-Responsive and antimicrobial polymer synthesis in continuous flow and effect of pendant alkylamine on the squaraine dye photocatalyst activity0 apHResponsive and antimicrobial polymer synthesis in continuous f  cMAY  a6287-63000 v83 a<p>
	pH-responsive and antimicrobial polymers were synthesized by photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization under blue light (lambda max = 485 nm) using a scalable continuous flow method. The effect of pendant alkylamino groups with different alkyl substituents on methacrylate monomers under blue light is investigated in the absence of a tertiary alkylamine reagent and in the presence of cyanopentanoic acid dithiobenzoate and 4-cyano-4-[(dodecylsulfanylthiocarbonyl) sulfanyl]pentanoic acid as RAFT agents. The rate of polymerization is found to vary with the size of the alkyl chain and with the tertiary, secondary, or quaternary nature of the amino group. The ability of pendant alkylamino groups to transfer electrons to the photocatalyst is shown using cyclic voltammetry and fluorescence quenching experiments; the tendency to suppress dye aggregation is observed using UV-vis spectroscopy; and the rates of polymerization could be correlated with the trend in these results. The mechanism of polymerization is proposed to follow a reductive or oxidative electron transfer pathway depending on the nature of the pendant group. Statistical and diblock copolymers with 2-hydroxyethyl methacrylate are synthesized in batch and continuous flow processes with a comparative study of kinetics in the two methods. The synthesis of high-molecular-weight homopolymer (55,000 g/mol) and statistical copolymer (85,000 g/mol) of N,N-diisopropylaminoethyl methacrylate is shown in continuous flow. The solution self-assembly of diblock copolymers is studied, and the pH-responsive morphology change leading to disassembly is shown. The antimicrobial properties of polymers with a quaternary ammonium pendant group are evaluated. The thermal degradation of statistical copolymers is analyzed.</p>
10aalkylaminoethyl methacrylate10aAntimicrobial10acontinuous flowprocess10aPET-RAFT10apH-responsive10aself-aggregation1 aPatil, Anil, M.1 aNawghare, Indrajeet, S.1 aSiby, Jesna1 aBankar, Priyanka, M.1 aDastager, Syed, G.1 aRode, Chandrashekhar, V.1 aNithyanandhan, Jayaraj1 aAmbade, Ashootosh, V.  uhttps://library.ncl.res.in/content/ph-responsive-and-antimicrobial-polymer-synthesis-continuous-flow-and-effect-pendant