01217nas a2200265 4500008004100000022001400041245008100055210006900136260000800205300001100213490000800224520040800232653000600640653000600646653001700652653001300669653001800682653002000700100002300720700002700743700002300770700002500793700002200818856011100840 2023 eng d a0040-403900aMetal-free isoamyl nitrite mediated efficient synthesis of 1,2,4-oxadiazoles0 aMetalfree isoamyl nitrite mediated efficient synthesis of 124oxa cJUL a1546160 v1253 a

We report herein, a metal-free isoamyl nitrite mediated efficient synthesis of 1,2,4-oxadiazoles by one pot cycloaddition reaction of aldoximes with nitriles. The structure of the 1,2,4-oxadiazole derivatives was confirmed by studies of spectral analysis. Current methodology provides a novel pathway to access 1,2,4-oxadiazole derivatives.& COPY; 2023 Elsevier Ltd. All rights reserved.

10a110a210a4-Oxadiazole10aAldoxime10aCycloaddition10aIsoamyl nitrite1 aGalave, Sharad, A.1 aKadam, Kishorkumar, S.1 aSonawane, Amol, D.1 aPansare, Vaibhav, R.1 aGarud, Dinesh, R. uhttps://library.ncl.res.in/content/metal-free-isoamyl-nitrite-mediated-efficient-synthesis-124-oxadiazoles