01565nas a2200193   4500008004100000245016700041210007100208260000800279300001600287490000700303520077100310100003001081700002301111700002901134700002401163700002401187700002101211856013901232       2023                        eng d00aOrganocatalysed one-pot three component synthesis of 3,3′-disubstituted oxindoles featuring an all-carbon quaternary center and [spiro 2H-pyran-3,4′-indoline]0 aOrganocatalysed onepot three component synthesis of 33′disubstit  cAPR  a13206-132120 v133 a<p>
	A simple and efficient methodology for the one-pot synthesis of 3,3 `-disubstituted oxindoles featuring an all-carbon quaternary center has been demonstrated through l-proline catalysed three-component reaction based on sequential Knoevenagel condensation/Michael addition and also one-pot synthesis of spiro[2H-pyran-3,4 `-indoline] through consecutive Knoevenagel condensation/Michael addition/reduction/cyclization reactions from readily available isatin derivatives, malononitrile, and ketones. The present methodology presents several advantages, including simple reaction set-up, short reaction times, and easy to work-up. Also, this strategy offers broad substrate scope with excellent yields and high atom economy, under mild reaction conditions.</p>
1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aChaudhari, Suryakant, S.1 aMali, Bhupendra, P.1 aGonnade, Rajesh, G.1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/organocatalysed-one-pot-three-component-synthesis-33%E2%80%B2-disubstituted-oxindoles-featuring-all01410nas a2200181   4500008004100000245015700041210007100198260000800269300001400277490000700291520066600298100002300964700003000987700002901017700002601046700002101072856013501093       2024                        eng d00aOrganocatalyzed [4+2] cycloaddition of α,β-unsaturated ketones and isatylidene malononitrile: accessing spiro[3-arylcyclohexanone]oxindole derivatives0 aOrganocatalyzed 42 cycloaddition of αβunsaturated ketones and is  cJAN  a2873-28770 v143 a<p>
	Herein, we developed a series of compounds featuring spiro[3-arylcyclohexanone]oxindoles through Barbas [4 + 2] cycloaddition reactions between isatylidene malononitrile and alpha,beta-unsaturated ketones using l-proline as an organocatalyst. The reported methodology offers many advantages such as mild reaction conditions, diverse substrate scope with high yields, easy reaction setup, and use of easily synthesizable starting materials. An l-proline catalyzed-Barbas-[4 + 2]-cycloaddition reaction is reported for the synthesis of spiro[3-arylcyclohexanone]oxindole derivatives. The method can tolerate a diverse substrate scope with high yields.</p>
1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aChaudhari, Suryakant, S.1 aKrishna, Gamidi, Rama1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/organocatalyzed-42-cycloaddition-%CE%B1%CE%B2-unsaturated-ketones-and-isatylidene-malononitrile