02056nas a2200205   4500008004100000022001400041245012600055210006900181260007100250300001600321490000700337520125700344100001701601700001801618700002401636700001601660700002301676700001901699856013201718       2005                        eng d  a0743-746300aBiocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview0 aBiocompatibility of gold nanoparticles and their endocytotic fat  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a10644-106540 v213 a<p>Macrophages are one of the principal immune effector cells that play essential roles as secretory, phagocytic, and antigen-presenting cells in the immune system. In this study, we address the issue of cytotoxicity and immunogenic effects of gold nanoparticles on RAW264.7 macrophage cells. The cytotoxicity of gold nanoparticles has been correlated with a detailed study of their endocytotic uptake using various microscopy tools such as atomic force microscopy (AFM), confocal-laser-scanning microscopy (CFLSM), and transmission electron microscopy (TEM). Our findings suggest that Au(0) nanoparticles are not cytotoxic, reduce the production of reactive oxygen and nitrite species, and do not elicit secretion of proinflammatory cytokines TNF-alpha and IL1-, making them suitable candidates for nanomedicine. AFM measurements suggest that gold nanoparticles are internalized inside the cell via a mechanism involving pinocytosis, while CFLSM and TEM studies indicate their internalization in lysosomal bodies arranged in perinuclear fashion. Our studies thus underline the noncytotoxic, nonimmunogenic, and biocompatible properties ofgold nanoparticles with the potential for application in nanoimmunology, nanomedicine, and nanobiotechnology.</p>1 aShukla, Ravi1 aBansal, Vipul1 aChaudhary, Manakshi1 aBasu, Atanu1 aBhonde, Ramesh, R.1 aSastry, Murali  uhttps://library.ncl.res.in/content/biocompatibility-gold-nanoparticles-and-their-endocytotic-fate-inside-cellular-compartment-001154nas a2200193   4500008004100000022001400041245011600055210006900171260007700240300000900317490000700326520042000333100001800753700001500771700001700786700001700803700001900820856012100839       2005                        eng d  a0935-964800aBioleaching of sand by the fungus fusarium oxysporum as a means of producing extracellular silica nanoparticles0 aBioleaching of sand by the fungus fusarium oxysporum as a means   aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAPR  a889+0 v173 a<p>A plant pathogenic fungus, Fusarium oxysporum, can be used as a biological model system for the extracellular bioleaching of hollow spherical silica nanoparticles (see Figure) from sand. The room-temperature synthesis of oxide nanomaterials using microorganisms starting from potential waste materials could lead to eco-friendly and economically viable methods for the large-scale synthesis of nanomaterials.</p>1 aBansal, Vipul1 aSanyal, A.1 aRautaray, D.1 aAhmad, Absar1 aSastry, Murali  uhttps://library.ncl.res.in/content/bioleaching-sand-fungus-fusarium-oxysporum-means-producing-extracellular-silica-0