02257nas a2200265   4500008004100000245015100041210006900192260000800261300000900269490000700278520133600285653001901621653002401640653001901664653001701683653001901700100001601719700002201735700002101757700002201778700002201800700001901822700001801841856013201859       2022                        eng d00aImproved mucoadhesion, permeation and in vitro anticancer potential of synthesized thiolated acacia and karaya gum combination: a systematic study0 aImproved mucoadhesion permeation and in vitro anticancer potenti  cOCT  a68290 v273 a<p>
	Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Anticancer potential of developed thiomer was studied on cervical cancer cell lines (HeLa) and more than 60% of human cervical cell lines (HeLa) were inhibited at concentration of 5 mu g/100 mu L. Immobilized thiol groups were found to be 0.8511 mmol/g as determined by Ellman's method. Cytotoxicity studies on L929 fibroblast cell lines indicated thiomers were biocompatible. Bilayered tablets were prepared using Ivabradine hydrochloride as the model drug and synthesized thiolated gums as mucoadhesive polymer. Tablets prepared using thiolated polymers in combination showed more swelling, mucoadhesion and residence time as compared to unmodified gums. Thiol modification controlled the release of the drug for 24 h and enhanced permeation of the drug up to 3 fold through porcine buccal mucosa as compared to tablets with unmodified gums. Thiolated polymer showed increased mucoadhesion and permeation, anticancer potential, controlled release and thus can be utilized as a novel excipient in formulation development.</p>
10abuccal tablets10aenhanced permeation10aivabradine HCl10amucoadhesion10athiolated gums1 aMunot, Neha1 aKandekar, Ujjwala1 aRikame, Chaitali1 aPatil, Abhinandan1 aSengupta, Poulomi1 aUrooj, Shabana1 aBilal, Anusha  uhttps://library.ncl.res.in/content/improved-mucoadhesion-permeation-and-vitro-anticancer-potential-synthesized-thiolated-acacia