02281nas a2200241 4500008004100000022001400041245010600055210006900161260000800230300001600238490000600254520145900260653002301719653001901742653002201761653002201783653002201805653001901827100002701846700001701873700002701890856012201917 2024 eng d a2637-610500aBiobased reusable nonisocyanate polyurethane hot-melt adhesives with potential chemical degradability0 aBiobased reusable nonisocyanate polyurethane hotmelt adhesives w cSEP a11180-111920 v63 a

Hot-melt adhesives (HMAs) derived from renewable resources are always attractive, as they promote less dependence on fossil resources and aid in developing environmentally friendly materials. However, developing sustainable HMAs exhibiting good adhesive performance and biodegradability remains challenging. Herein, reusable biobased HMAs with a high bio content of 88-90%, biodegradability, and tunable adhesive nature were developed as a possible alternative to conventional petroleum-based hot-melt adhesives. Moreover, the structure-property relationship of the product was investigated in detail. By tailoring the monomer composition, NIPU-40 HMA exhibited a good bonding ability with a superior adhesion strength of 6.39 MPa. To the best of our knowledge, this is the highest adhesion strength observed when bonding with an Al substrate among the biobased thermoplastic NIPU-HMAs. Impressively, NIPU-HMAs could display excellent reusability even after three bonding and debonding cycles without a significant drop in the adhesive strength and were found to exhibit good adhesion performance under wet conditions. More importantly, the NIPU-HMAs are prone to degradation under acid-catalyzed conditions. Considering their features, these biobased NIPU thermoplastic hot-melt adhesives offer an opportunity to create environmentally friendly, degradable adhesives that possess excellent adhesive strength and can be reused multiple times.

10aacid degradability10abiobased NIPUs10acyclic carbonates10ahot meltadhesives10alap shearstrength10aspiro-aromatic1 aGhuge, Gorakh, Hiraman1 aTorris, Arun1 aNair, Kiran, Sukumaran uhttps://library.ncl.res.in/content/biobased-reusable-nonisocyanate-polyurethane-hot-melt-adhesives-potential-chemical02769nas a2200229 4500008004100000245012000041210006900161260000800230300001100238490000800249520195200257653002702209653001502236653003002251653002102281100002102302700001702323700002602340700002002366700002702386856012602413 2024 eng d00aBiodegradable and 3D printable lysine functionalized polycaprolactone scaffolds for tissue engineering applications0 aBiodegradable and 3D printable lysine functionalized polycaprola cMAY a2138160 v1593 a

Tissue engineering (TE) has sparked interest in creating scaffolds with customizable properties and functional bioactive sites. However, due to limitations in medical practices and manufacturing technologies, it is challenging to replicate complex porous frameworks with appropriate architectures and bioactivity in vitro. To address these challenges, herein, we present a green approach that involves the amino acid (L-lysine) initiated polymerization of epsilon-caprolactone (CL) to produce modified polycaprolactone (PCL) with favorable active sites for TE applications. Further, to better understand the effect of morphology and porosity on cell attachment and proliferation, scaffolds of different geometries with uniform and interconnected pores are designed and fabricated, and their properties are evaluated in comparison with commercial PCL. The scaffold morphology and complex internal micro-architecture are imaged by micro-computed tomography (micro-CT), revealing pore size in the range of similar to 300-900 mu m and porosity ranging from 30 to 70 %, while based on the geometry of scaffolds the compressive strength varied from 143 +/- 19 to 214 +/- 10 MPa. Additionally, the degradation profiles of fabricated scaffolds are found to be influenced by both the chemical nature and product design, where Lys-PCL-based scaffolds with better porosity and lower crystallinity degraded faster than commercial PCL scaffolds. According to in vitro studies, Lys-PCL scaffolds have produced an environment that is better for cell adhesion and proliferation. Moreover, the scaffold design affects the way cells interact; Lys-PCL with zigzag geometry has demonstrated superior in vitro vitality (>90 %) and proliferation in comparison to other designs. This study emphasizes the importance of enhancing bioactivity while meeting morphology and porosity requirements in the design of scaffolds for tissue engineering applications.

10aAdditive manufacturing10aAmino acid10aMicro-computed tomography10aPolycaprolactone1 aNaik, Sonali, S.1 aTorris, Arun1 aChoudhury, Namita, R.1 aDutta, Naba, K.1 aNair, Kiran, Sukumaran uhttps://library.ncl.res.in/content/biodegradable-and-3d-printable-lysine-functionalized-polycaprolactone-scaffolds-tissue02083nas a2200241 4500008004100000022001400041245015700055210006900212260000900281300001200290490000700302520118800309653002201497653002301519653002101542653002801563653002301591100002501614700002401639700002701663700002601690856012501716 2025 eng d a1060-132500aBio-based poly(isobornyl acrylate)-b-(citronellyl methacrylate) block copolymers by PET-RAFT polymerization: thiol-ene modification and adhesion studies0 aBiobased polyisobornyl acrylatebcitronellyl methacrylate block c cSEP  a728-7360 v623 a

In this study, poly(isobornyl acrylate)-b-poly(citronellyl methacrylate) (PIBA-b-PCMA) block copolymers were synthesized with controlled molecular weights and low dispersity using photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization of isobornyl acrylate (IBA) and citronellyl methacrylate (CMA), both terpene-derived monomers. A series of block copolymers was obtained by varying the chain length of PCMA block. Kinetics study of the polymerization of IBA and CMA using 4-cyano-(((dodecylthio)carbonothioyl)thio)pentanoic acid (CDTPA) as chain transfer agent showed a linear plot of ln[M]0/[M]t vs time indicating first order reaction. Distinct glass transition temperatures were observed for the individual blocks and enhanced thermal stability was seen with increasing PCMA content. Post-polymerization modification of the polymer was demonstrated using thiol-ene reaction with the vinyl group in the pendent citronellyl moiety. Adhesion performance, evaluated through lap shear test on aluminum substrates, showed that the block copolymers achieved peak shear strengths of 1.74 MPa at a 38:62 PIBA:PCMA mole ratio.

10aadhesion strength10aBio-based polymers10ablock copolymers10aPET-RAFT polymerization10aThiol-ene reaction1 aHetkale, Pragati, M.1 aPurohit, Poorvi, M.1 aNair, Kiran, Sukumaran1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/bio-based-polyisobornyl-acrylate-b-citronellyl-methacrylate-block-copolymers-pet-raft