01505nas a2200181   4500008004100000022001400041245009600055210006900151260000800220300001400228490000700242520086100249100001801110700002301128700002501151700002401176856012301200       2022                        eng d  a1523-706000aNickel-catalyzed direct synthesis of N-substituted indoles from amino alcohols and alcohols0 aNickelcatalyzed direct synthesis of Nsubstituted indoles from am  cDEC  a9054-90590 v243 a<p>
	A one-pot cascade approach for the synthesis of N substituted indoles from amino alcohols and alcohols under additive and base-free conditions with the liberation of water as the only stoichiometric byproduct is reported. The commercially available bench-stable Ni(OTf)2 salt in combination with 1,2-bis(dicyclohexylphosphino)ethane (dcype) is very effective for this unprecedented catalytic transformation. A broad range of substrates including aromatic and aliphatic primary alcohols, cyclic and acyclic secondary alcohols, and various substituted 2-aminophenyl ethyl alcohols are employed in the reaction conditions to provide a diverse range of N-alkylated indoles. Mechanistic studies revealed that the reaction proceeds through tandem N-alkylation via hydrogen autotransfer followed by the cyclization of N-alkylated alcohol intermediate.</p>
1 aYadav, Vinita1 aJagtap, Sayali, G.1 aBalaraman, Ekambaram1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/nickel-catalyzed-direct-synthesis-n-substituted-indoles-amino-alcohols-and-alcohols01671nas a2200169   4500008004100000022001400041245015500055210006900210260000800279300001400287490000700301520099700308100002101305700002301326700002401349856012801373       2025                        eng d  a1523-706000aNHC-catalyzed allylation of aldehydes with MBH carbonates and their michael addition-elimination-cope rearrangement cascade: a route to rac-sacubitril0 aNHCcatalyzed allylation of aldehydes with MBH carbonates and the  cMAY  a5911-59160 v273 a<p>
	We report herein a novel NHC-catalyzed transition-metal-free chemoselective allylation of aldehydes with Morita-Baylis-Hillman (MBH) carbonates using an inorganic base. Fascinatingly, the use of an organic base follows a different mechanism, leading to highly functionalized 1,5-dienes via a Michael addition-elimination reaction followed by [3,3]-sigmatropic Cope rearrangement. The described method harnesses a new Csp2-Csp3 bond to access alpha-methylene-gamma-oxo-gamma-substituted ester derivatives paving a way to facile synthesis of potent natural products and active pharmaceutical ingredients (APIs). A broad range of aromatic and aliphatic aldehydes with MBH carbonates was employed to provide a variety of interesting butanoate and dienyl ketone scaffolds in good to excellent yields. This chemistry has been extended to the efficient syntheses of rac-sacubitril API and gamma-butyrolactone scaffold, which is a privileged core present in many natural products and APIs</p>
1 aKale, Tushar, B.1 aJagtap, Sayali, G.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/nhc-catalyzed-allylation-aldehydes-mbh-carbonates-and-their-michael-addition-elimination