00659nas a2200157 4500008004100000022001400041245013300055210006900188260000800257300001100265100002100276700002600297700002600323700002300349856012900372 2023 eng d a1551-700400aUltrasound assisted synthesis of spirooxindolo-1,2,4-oxadiazoles via [3+2] cycloaddition reaction and their anti-cancer activity0 aUltrasound assisted synthesis of spirooxindolo124oxadiazoles via cMAY aS1-S461 aKanchrana, Madhu1 aAllaka, Bhargava, Sai1 aKrishna, Gamidi, Rama1 aBasavoju, Srinivas uhttps://library.ncl.res.in/content/ultrasound-assisted-synthesis-spirooxindolo-124-oxadiazoles-32-cycloaddition-reaction-and00951nas a2200253 4500008004100000022001400041245018800055210006900243260001300312300001400325490000700339653000600346653001800352653002600370653001400396653003100410653002300441100002100464700002600485700001900511700002400530700002300554856012000577 2024 eng d a1381-199100aDesign, synthesis, anti-mycobacterial activity, molecular docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation0 aDesign synthesis antimycobacterial activity molecular docking an cDEC 2024 a3979-39910 v2810a210a4-oxadiazoles10acytotoxicity activity10amolecular10aMycobacterium tuberculosis10aSpiroquinoxaline-11 aKanchrana, Madhu1 aGamidi, Rama, Krishna1 aKumari, Jyothi1 aSriram, Dharmarajan1 aBasavoju, Srinivas uhttps://library.ncl.res.in/content/design-synthesis-anti-mycobacterial-activity-molecular-docking-and-adme-analysis00867nas a2200241 4500008004100000022001400041245012700055210006900182260000800251300001500259490000600274653001800280653001900298100002100317700002600338700001800364700002000382700002500402700003100427700002000458700002300478856012400501 2024 eng d a2365-654900aIonic liquid assisted green synthesis of quinoxaline based bisspirooxindoles: anticancer evaluation and molecular dynamics0 aIonic liquid assisted green synthesis of quinoxaline based bissp cNOV ae2024036080 v910aCycloaddition10aspirooxindoles1 aKanchrana, Madhu1 aKrishna, Gamidi, Rama1 aDey, Biswajit1 aPandey, Nandita1 aGuru, Santosh, Kumar1 aSangolkar, Akanksha, Ashok1 aPawar, Ravinder1 aBasavoju, Srinivas uhttps://library.ncl.res.in/content/ionic-liquid-assisted-green-synthesis-quinoxaline-based-bisspirooxindoles-anticancer02051nas a2200157 4500008004100000245016900041210006900210260000800279490000700287520137700294100002601671700002101697700002601718700002301744856012601767 2024 eng d00a Synthesis of quinazolinone based spirocyclopropanes via [3?+?2] cycloaddition reaction: in silico anti-tubercular molecular docking studies and ADME prediction0 aSynthesis of quinazolinone based spirocyclopropanes via 32 cyclo cSEP0 v443 a

A highly efficient cascade annulation approach is developed for the synthesis of novel quinazolinone-based spirocyclopropanes via three-component [3ā€‰+ā€‰2] cycloaddition reaction with aldehydes, tosylhydrazide and quinazolinyl chalcones. The reaction features the formation of two Cā€“C bonds and three stereogenic centers. A variety of highly functionalized spirocyclopropyl quinazolinones were obtained in good yields under mild reaction conditions. Furthermore, in silico anti-tubercular (anti-TB) molecular docking studies were performed for the generated compounds against three Mycobacterium tuberculosis proteins with PDBID: 1DF7, 1P44 and 4TZK. ADME prediction were evaluated for the drug like properties of the synthesized compounds.

1 aAllaka, Bhargava, Sai1 aKanchrana, Madhu1 aGamidi, Rama, Krishna1 aBasavoju, Srinivas uhttps://library.ncl.res.in/content/synthesis-quinazolinone-based-spirocyclopropanes-32-cycloaddition-reaction-silico-anti