01371nas a2200169   4500008004100000022001400041245012500055210006900180260000900249300001400258490000700272520071400279100002700993700002401020700002701044856013001071       2023                        eng d  a1477-052000aConstruction of the quinobenzoxazine core via gold-catalyzed dual annulation of azide-tethered alkynones with anthranils0 aConstruction of the quinobenzoxazine core via goldcatalyzed dual  cMAR   a2127-21370 v213 a<p>
	A new catalytic method for the construction of the quinobenzoxazine core has been developed employing the gold-catalyzed cyclization of o-azidoacetylenic ketones in the presence of anthranils. The overall process comprises of a gold-catalyzed 6-endo-dig cyclisation of o-azidoacetylenic ketone leading to a alpha-imino gold carbene and subsequent carbene transfer to anthranil leading to the 3-aryl-imino-quinoline-4-one intermediate, which undergoes 6 pi-electrocyclization and aromatization to form the central quinobenzoxazine core. This transformation provides a new approach to a diverse array of quinobenzoxazine structures, in addition to being scalable and having mild reaction conditions.</p>
1 aHalnor, Swapnil, V. V.1 aDhote, Pawan, S. S.1 aRamana, Chepuri, V. V.  uhttps://library.ncl.res.in/content/construction-quinobenzoxazine-core-gold-catalyzed-dual-annulation-azide-tethered-alkynones