01704nas a2200205   4500008004100000022001400041245009100055210006900146260000800215300001600223490000700239520100400246100002301250700002001273700002701293700002101320700002001341700002101361856011601382       2022                        eng d  a2041-652000aBQ-AurIPr: a redox-active anticancer Au(i) complex that induces immunogenic cell death0 aBQAurIPr a redoxactive anticancer Aui complex that induces immun  cSEP  a10779-107850 v133 a<p>
	Immunogenic Cell Death (ICD) is a unique cell death mechanism that kills cancer cells while rejuvenating the anticancer immunosurveillance, thereby benefiting the clinical outcomes of various immuno-chemotherapeutic regimens. Herein, we report development of a library of benzo[a]quinolizinium-based Au(i) complexes through an intramolecular amino-auration reaction of pyridino-alkynes. We tested 40 candidates and successfully identified BQ-AurIPr as a novel redox-active Au(i) complex with potent anticancer properties. BQ-AurIPr efficiently triggered generation of DAMPs - the hallmarks of ICD - and was superior in terms of efficiency compared to FDA-approved drugs known to induce ICD. BQ-AurIPr significantly increased immunogenicity of cancer cells enhancing their phagocytosis when co-cultured with immune cells. Our investigation reveals that BQ-AurIPr induces oxidative stress inside mitochondria leading to mitophagy, as the mechanism for immunogenic cell death in A549 cells.</p>
1 aMule, Ravindra, D.1 aKumar, Akhilesh1 aSancheti, Shashank, P.1 aSenthilkumar, B.1 aKumar, Himanshu1 aPatil, Nitin, T.  uhttps://library.ncl.res.in/content/bq-auripr-redox-active-anticancer-aui-complex-induces-immunogenic-cell-death