00996nas a2200217 4500008004100000022001400041245004500055210004100100260000800141300001200149490000700161520038400168653001400552653002500566653002000591653002500611653001600636100002600652700002100678856007900699 2025 eng d a0936-521400aGram-scale synthesis of (±)-tylophorine0 aGramscale synthesis of ±tylophorine cMAR a536-5400 v363 a

We report a practical scalable synthesis of the natural product (+/-)-tylophorine by using an operationally simple protecting-group-free route from readily accessible starting materials. Synthesis of a cyclic N-acetyl diester compound through cyclization, followed by two key steps (decarboxylation and a Clemmensen reduction), provides access to the target molecule.

10aalkaloids10aClemmensen reduction10adecarboxylation10agram-scale synthesis10atylophorine1 aMasal, Dattatraya, P.1 aReddy, Srinivasa uhttps://library.ncl.res.in/content/gram-scale-synthesis-%C2%B1-tylophorine