02558nas a2200169   4500008004100000245006800041210006800109260003200177300001000209490000900219520198900228100001902217700001902236700001502255700002102270856009702291       2017                        eng d00aGlobal conformation of Tau protein mapped by Raman spectroscopy0 aGlobal conformation of Tau protein mapped by Raman spectroscopy  aNew YorkbHumana Press Inc.  a21-310 v15233 aAlzheimer’s disease (AD) is one of the neurodegenerative disease characterized by progressive neuronal loss in the brain. Its two major hallmarks are extracellular senile plaques and intracellular neurofibrillary tangles (NFTs), formed by aggregation of amyloid β-42 (Aβ-42) and Tau protein respectively. Aβ-42 is a transmembrane protein, which is produced after the sequential action of β- and γ-secretases, thus obtained peptide is released extracellularly and gets deposited on the neuron forming senile plaques. NFTs are composed of microtubule-associated protein-Tau (MAPT). Tau protein’s major function is to stabilize the microtubule that provides a track on which the cargo proteins are shuttled and the stabilized microtubule also maintains shape and integrity of the neuronal cell. Tau protein is subjected to various modifications such as phosphorylation, ubiquitination, glycation, acetylation, truncation, glycosylation, deamination, and oxidation; these modifications ultimately lead to its aggregation. Phosphorylation is the major modification and is extensively studied with respect to Tau protein. Tau protein, however, undergoes certain level of phosphorylation and dephosphorylation, which regulates its affinity for microtubule and ultimately leading to microtubule assembly and disassembly. Our main aim was to study the native state of longest isoform of Tau (hTau40WT-4R2N) and its shortest isoform, (hTau23WT-3R0N), at various temperatures such as 10, 25, and 37 °C. Raman spectroscopic results suggested that the proportion of random coils or unordered structure depends on the temperature of the protein environment. Upon increase in the temperature from 10 to 37 °C, the proportion of random coils or unordered structures increased in the case of hTau40WT. However, we did not find a significant effect of temperature on the structure of hTau23WT. This current approach enables one to analyze the global conformation of soluble Tau in solution. 1 aGorantla, N.V.1 aKhandelwal, P.1 aPoddar, P.1 aChinnathambi, S.  uhttps://library.ncl.res.in/content/global-conformation-tau-protein-mapped-raman-spectroscopy01966nas a2200169   4500008004100000022001400041245014300055210007000198260000900268300001500277490000600292520132300298100001401621700001501635700001501650856013101665       2018                        eng d  a2470-134300aGraphene quantum dots-driven multiform morphologies of β-NaYF4:Gd3+/Tb3+ phosphors: the underlying mechanism and their optical properties0 aGraphene quantum dotsdriven multiform morphologies of βNaYF4Gd3T  cFEB   a1834 -18490 v33 aDimension and shape tunable architectures of inorganic crystals are of extreme interest because of morphology-dependent modulation of the properties of the materials. Herein, for the first time, we present a novel impurity-driven strategy where we studied the influence of in situ incorporation of graphene quantum dots (GQDs) on the growth of β-NaYF4:Gd3+/Tb3+ phosphor crystals via a hydrothermal route. The GQDs function as a nucleation site and by changing the concentration of GQDs, the morphology of β-NaYF4:Gd3+/Tb3+ phosphors was changed from rod to flowerlike structure to disklike structure, without phase transformation. The influence of size and functionalization of GQDs on the size and shape of phosphor crystals were also systematically studied and discussed. Plausible mechanisms of formation of multiform morphologies are proposed based on the heterogeneous nucleation and growth. Most interestingly, the experimental results indicate that the photoluminescence properties of β-NaYF4:Gd3+/Tb3+ phosphor crystals are strongly dependent on the crystallite size and morphology. This study would be suggestive for the precisely controlled growth of inorganic crystals; consequently, it will open new avenues and thus may possess potential applications in the field of materials and biological sciences.1 aMalik, M.1 aPadhye, P.1 aPoddar, P.  uhttps://library.ncl.res.in/content/graphene-quantum-dots-driven-multiform-morphologies-%CE%B2-nayf4gd3tb3-phosphors-underlying