01569nas a2200145   4500008004100000245015300041210006900194260000800263300001600271490000700287520095300294100002901247700002201276856012501298       2022                        eng d00aPoly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride0 aPolyNvinylcaprolactam containing solid lipid polymer hybrid nano  cJUN  a17621-176280 v123 a<p>
	Folic acid tagged and hydrophilic polymer containing solid lipid nanoparticles (SLNs) were formulated for the controlled and targeted delivery of gemcitabine, a hydrophilic drug. Drug loaded SLNs were prepared by double emulsion method and optimized by 3(2) level factorial design. Then, a hydrophilic polymer, namely, poly(N-vinylcaprolactam) (PVCL) was incorporated in the optimized SLN batch in the first aqueous phase (W1) to obtain solid lipid polymer hybrid nanoparticles (SLPHNs) that were further decorated with folic acid (F-SLPHNs). TEM analysis of SLNs and SLPHNs revealed the spherical shape with no aggregation while SLPHNs showed higher % EE. SLPHNs exhibited limited burst release of gemcitabine compared to SLNs as well as lower overall % release. All the formulations showed good cytocompatibility against MDA-MB-231 cell lines and folic acid-tagged hybrid particles (F-SLPHNs) showed remarkably higher cellular uptake.</p>
1 aSurapaneni, Sai, Geetika1 aAmbade, Ashootosh  uhttps://library.ncl.res.in/content/polyn-vinylcaprolactam-containing-solid-lipid-polymer-hybrid-nanoparticles-controlled02241nas a2200241   4500008004100000022001400041245018700055210006900242260000800311300001100319490000800330520134800338653001801686653001301704653001801717653001801735653002001753653003101773100002201804700002601826700002201852856012501874       2024                        eng d  a0014-305700aPhoto and pH dual stimuli-responsive block copolymer micelles with defined incorporation of o-nitrobenzyl units in poly(ε-caprolactone) ε-caprolactone) block for controlled release0 aPhoto and pH dual stimuliresponsive block copolymer micelles wit  cNOV  a1135010 v2203 a<p>
	A series of dual stimuli-responsive block copolymers with varying content of photocleavable o-nitrobenzyl (ONB) ester group pendent in the hydrophobic poly(epsilon-caprolactone) block and pH-cleavable acetal linkage at the junction with hydrophilic poly(ethylene glycol) block is synthesized. The hydrophobic block is a random copolymer synthesized by ring-opening copolymerization of epsilon-caprolactone and ONB-substituted epsilon-caprolactone containing varying compositions of the two monomers. Kinetics of polymerization shows that ONBfunctionalized monomer has lower reactivity than that of the unsubstituted monomer. The series of block copolymers shows self-assembly into well-defined spherical micelles of average size of 150-200 nm in aqueous solution. Photocleavage of ONB groups is studied by NMR and UV-vis spectroscopy, and its extent is determined. The two stimuli viz. . UV light and pH are used individually as well as simultaneously to study the controlled release of the encapsulated drug Camptothecin and the synergistic effect of the two stimuli is demonstrated. The effect of varying content of ONB groups is observed on drug release profile. MTT assay showed non-cytotoxic nature of the polymer. Cell uptake and photoinduced release of doxorubicin (DOX) from the micelles in MDAMB-231 cells is demonstrated.</p>
10adrug delivery10amicelles10aO-nitrobenzyl10apH-responsive10aPhotoresponsive10aPoly(epsilon-caprolactone)1 aAvhad, Shankarrao1 aChoudhari, Shakeb, N.1 aAmbade, Ashootosh  uhttps://library.ncl.res.in/content/photo-and-ph-dual-stimuli-responsive-block-copolymer-micelles-defined-incorporation-o