01853nas a2200229   4500008004100000022001400041245009100055210006900146260000800215300000800223490000700231520111800238653001601356653002101372653001701393653001501410653001601425100002101441700001801462700002401480856011901504       2022                        eng d  a1530-993200aCholine-amino acid-derived bio-ionic liquids for solubility enhancement of zafirlukast0 aCholineamino acidderived bioionic liquids for solubility enhance  cMAY  a1460 v233 a<p>
	This study investigated the application of bio-ionic liquids (ILs) prepared from choline as cation and amino acid as anion for solubility enhancement of poorly water-soluble drug, Zafirlukast (ZFL). Herein, the solubility of ZFL in water and mixtures of water and ILs was assessed using UV spectroscopy at two temperature points 25 degrees C and 37 degrees C with increasing concentrations of IL. ZFL solubility was found to improve linearly with increasing concentration of [Ch][Pro] in water, representing 35- to 37-fold improvement in ZFL solubility at maximum concentration of [Ch][Pro] (1% w/v) compared to when only pure water was present. Also, the effect of IL on ZFL solubility was analyzed using NMR, DSC, and TGA. These results clearly suggest that ZFL solubility was increased by forming hydrogen bonds with selected [Ch][Pro] IL. Toxicity study of ILs was tested against gram-positive and gram-negative bacteria. Since IL solvent was found to increase the solubility of ZFL, this may serve as ``functional excipient solvent'' for solubility enhancement in its commercialized formulations.</p>
10aAmino acids10acholine chloride10aIonic liquid10asolubility10azafirlukast1 aGaikwad, Namrata1 aKudal, Swapna1 aAvachat, Amelia, M.  uhttps://library.ncl.res.in/content/choline-amino-acid-derived-bio-ionic-liquids-solubility-enhancement-zafirlukast