02582nas a2200253   4500008004100000022001400041245020300055210006900258260000800327300001100335490000700346520160900353653003101962653002801993653001902021653002802040653002302068100002402091700002202115700001902137700002402156700002302180856012502203       2022                        eng d  a2214-714400aDesign of hydrodynamic cavitation assisted intensified tertiary treatment unit for effective degradation of organic micropollutants in pharmaceutical industrial effluent: a case study with triclosan0 aDesign of hydrodynamic cavitation assisted intensified tertiary   cOCT  a1031320 v493 a<p>
	Increasing occurrence of micropollutants and trace amount of persistent organic contaminants (POC's) in the wastewater streams even after the well-established conventional treatment is a threat to human health, aquatic entities, and constitute a formidable challenge for the ecological security. In this regard, hydrodynamic cavi-tation based advanced oxidation treatment has attracted extensive attention towards removal of such micro scale pollutants from wastewater streams in the present scenario. Hence, the present work demonstrates the design and application of a rotating hydrodynamic cavitation (RHC) reactor with stator-rotor arrangement for effective degradation of organic micropollutants (triclosan being taken as the target pollutant) from tertiary effluents occurring in the pharmaceutical sector. The process performance was evaluated through optimization of geo-metric parameters of the reactor, various operating parameters as well as by studying the sole and synergistic performance of the HC process combined with other AOPs. The maximum degradation of Triclosan (TCS) ach-ieved by RHC alone was found to be 35.2 % and in synergism, with ozone, a maximum of 97.6 % degradation was observed. Further, to ensure the mineralization of the components, total organic carbon (TOC) contents of the samples were measured and the degradation pathway was predicted through LC-MS analysis. The techno-economic feasibility of the process were understood through economic and energetic analysis and technology transfer was done for replicating the same study for a pilot scale reactor.</p>
10aAdvanced oxidation process10aHydrodynamic cavitation10aMicropollutant10aPharmaceutical effluent10aTertiary treatment1 aMishra, Birupakshya1 aMukherjee, Anupam1 aMullick, Aditi1 aBhandari, Vinay, M.1 aMoulik, Siddhartha  uhttps://library.ncl.res.in/content/design-hydrodynamic-cavitation-assisted-intensified-tertiary-treatment-unit-effective02778nas a2200325   4500008004100000245012400041210006900165260000800234300000700242490000700249520169500256653002401951653002001975653002701995653002302022653001702045653001402062653002002076653002802096100002202124700002202146700002202168700002302190700002602213700001902239700002202258700001802280700002202298856013202320       2023                        eng d00aAntiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection0 aAntiviral and ROS scavenging potential of Carica papaya Linn and  cMAR  a820 v233 a<p>
	Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects. Thus, there is a continuous need to explore safe and efficacious anti-retroviral agents. Carica papaya Linn and Psidium guajava are known for their various biological activities. In this study, we characterized the bioactive fractions of methanolic leaves extract from both plants using the High-resolution electrospray ionization mass spectrometry (HR-ESI-MS) technique, followed by the investigation of their potential as anti-HIV-1 and antioxidant agents through in vitro mechanistic assays. The anti-HIV-1 activity was examined in TZM-bl cells through luciferase gene assay against two different clades of HIV-1 strains, whereas the intracellular ROS generation was analyzed by Fluorescence-Activated Cell Sorting. Additionally, the mechanisms of action of these phyto-extracts were determined through the Time-of-addition assay. The characterization of Carica papaya Linn and Psidium guajava leaves extract through HR-ESI-MS fragmentation showed high enrichment of various alkaloids, glycosides, lipids, phenolic compounds, terpenes, and fatty acids like bioactive constituents. Both the phyto-extracts were found to be less toxic and exhibited potent antiviral activity against HIV-1 strains. Furthermore, the phyto-extracts also showed a decreased intracellular ROS in HIV-1 infected cells due to their high antioxidant potential. Overall, our study suggests the anti-HIV-1 potential of Carica papaya Linn and Psidium guajava leaves extract due to the synergistic action of multiple bioactive constituents.</p>
10aanti-HIV-1 activity10aAnti-retroviral10aBioactive constituents10aCarica papaya Linn10aCytotoxicity10aHR-ESI-MS10aPsidium guajava10areactive oxygen species1 aJadaun, Pratiksha1 aShah, Prachibahen1 aHarshithkumar, R.1 aSaid, Madhukar, S.1 aBhoite, Shubhangi, P.1 aBokuri, Sowmya1 aRavindran, Selvan1 aMishra, Neetu1 aMukherjee, Anupam  uhttps://library.ncl.res.in/content/antiviral-and-ros-scavenging-potential-carica-papaya-linn-and-psidium-guajava-leaves-extract00896nas a2200241   4500008004100000245013800041210006900179260000800248490000700256653001400263653001800277100002200295700002200317700002400339700002600363700002600389700002600415700001900441700002600460700001800486700002200504856012800526       2024                        eng d00aMitochondrial resilience and antioxidant defence against HIV-1: unveiling the power of Asparagus racemosus extracts and Shatavarin IV0 aMitochondrial resilience and antioxidant defence against HIV1 un  cOCT0 v1510aIN-SILICO10aINHIBIT HIV-11 aJadaun, Pratiksha1 aHarshithkumar, R.1 aSeniya, Chandrabhan1 aGaikwad, Shraddha, Y.1 aBhoite, Shubhangi, P.1 aChandane-Tak, Madhuri1 aBorse, Swapnil1 aChavan-Gautam, Preeti1 aTillu, Girish1 aMukherjee, Anupam  uhttps://library.ncl.res.in/content/mitochondrial-resilience-and-antioxidant-defence-against-hiv-1-unveiling-power-asparagus