01631nas a2200193 4500008004100000022001400041245015300055210006900208260000900277300001400286490000700300520087800307100002501185700002101210700002801231700002301259700002601282856012901308 2022 eng d a1144-054600aDiethyl phosphite-mediated switchable synthesis of bis(imidazoheterocycles) derived disulfanes and sulfanes using imidazoheterocycles and octasulfur0 aDiethyl phosphitemediated switchable synthesis of bisimidazohete cMAR  a4784-47910 v463 a

A practical and highly efficient oxidative dual C-H sulfenylation of imidazoheterocycles using odorless, inexpensive elemental sulfur in DMSO to synthesize sulfur-bridged imidazoheterocycles under metal-free conditions is reported. The amount of diethyl phosphite and sulfur powder most attractively permits a tunable synthesis of bis(imidazoheterocycle)disulfanes and bis(imidazoheterocycle)sulfanes in good to high yields. A comprehensive substrate scope with a broad range of functional group tolerance was realized, and the efficacy of the process was proved at gram-scale reactions. Next, the bis(imidazopyridine)disulfanes were smoothly reacted with various indoles under similar conditions to form the corresponding imidazo[1,2-a]pyridine-indole-derived thioethers in high yields. A plausible mechanism has been proposed based on the control experiments.

1 aReddy, Raju, Jannapu1 aShankar, Angothu1 aKumar, Jangam, Jagadesh1 aSharadha, Nunavath1 aKrishna, Gamidi, Rama uhttps://library.ncl.res.in/content/diethyl-phosphite-mediated-switchable-synthesis-bisimidazoheterocycles-derived-disulfanes02045nas a2200181 4500008004100000022001400041245016200055210006900217260000800286300001400294490000700308520132400315100002501639700002701664700002301691700002601714856012301740 2022 eng d a0022-326300aSolvent-driven mono- and bis-sulfenylation of (E)-beta-iodovinyl sulfones with thiols for flexible synthesis of 1,2-thiosulfonylalkenes and 1,2-dithioalkenes0 aSolventdriven mono and bissulfenylation of Ebetaiodovinyl sulfon cMAR a3934-39510 v873 a

The nature of solvent is a key factor for stereoselective mono-and bis-thiolation of (E)-beta-iodovinyl sulfones with thiols under basic conditions. A novel and unprecedented vicinal bisthiolation of (E)-beta-iodovinyl sulfones with thiols under the influence of K2CO3/DMSO at room temperature for quick assembly of (E)-1,2-dithio-1-alkenes is presented. Solvent-induced stereoselective monosulfenylation of (E)-beta-iodovinyl sulfones with thiols has also been established for the synthesis of both (E)- and (Z)-1,2-thiosulfonylethenes in MeCN and MeOH, respectively. Moreover, K2CO3-mediated desulfonylative-sulfenylation of (Z)-1,2-thiosulfonylethenes with thiols in DMSO furnished unsymmetrical (Z)-1,2-dithio-1-alkenes for the first time. The solvent-dependent versatile reactivity of (E)-beta-iodovinyl sulfones has been successfully explored to provide a set of (E)-/(Z)-1,2-dithio-1-alkenes and (E)-/(Z)-1,2-thiosulfonyl-1-alkenes in good to high yields with excellent stereoselectivities. Notably, this operationally simple process utilizes a broad substrate scope with good functional group tolerance and compatibility. The efficacy of the process has been proven for gram-scale reactions, and plausible mechanistic models are outlined on the basis of experimental results and control experiments.

1 aReddy, Raju, Jannapu1 aKumari, Arram, Haritha1 aSharadha, Nunavath1 aKrishna, Gamidi, Rama uhttps://library.ncl.res.in/content/solvent-driven-mono-and-bis-sulfenylation-e-beta-iodovinyl-sulfones-thiols-flexible01720nas a2200169 4500008004100000022001400041245019400055210006900249260000900318300001400327490000700341520099300348100002501341700002301366700002601389856013501415 2023 eng d a0022-326300aPd(II)-catalyzed tandem cycloannulative-alkenylation of o-alkynyl-phenols/anilines with (E)-β-Iodovinyl sulfones: a direct strategy to construct 3-(Vinyl sulfonyl)benzoheterole derivatives0 aPdIIcatalyzed tandem cycloannulativealkenylation of oalkynylphen cJUN  a8889-89030 v883 a

Benzoheterolesand vinyl sulfones are the most promisingpharmaceuticalrelevance motifs, yet the hybrid analogues of these scaffolds stillneed to be explored. We report herein a general and highly efficientPd(OAc)(2)-catalyzed intramolecular cyclization and vinylationof o-alkynylphenols/o-alkynylanilineswith (E)-beta-iodovinyl sulfones under mild reactionconditions. A direct C(sp(2))-C(sp(2)) cross-couplingis enabled for the diversity-oriented synthesis of vinyl sulfone-tetheredbenzofurans and indoles in good to high yields with excellent stereoselectivity.Notably, this tandem process was consistent at the gram scale, andin situ, generation of 2-(phenylethynyl)phenol has also been utilizedin a scalable synthesis. Late-stage synthetic transformations werealso further explored, including isomerization and desulfonylative-sulfenylation.Moreover, several control experiments were accomplished, and we proposeda plausible mechanism based on existing experimental results.

1 aReddy, Raju, Jannapu1 aSharadha, Nunavath1 aKrishna, Gamidi, Rama uhttps://library.ncl.res.in/content/pdii-catalyzed-tandem-cycloannulative-alkenylation-o-alkynyl-phenolsanilines-e-%CE%B2-iodovinyl00909nas a2200241 4500008004100000022001400041245019200055210006900247260000900316490000700325653000600332653001400338653001600352653002000368653001200388653001300400100002700413700002800440700002300468700002600491700002500517856012500542 2024 eng d a1864-563100aVisible-light-induced radical sulfonylative-cyclization cascade of 1,6-Enynol derivatives with sulfinic acids: a sustainable approach for the synthesis of 2,3-disubstituted benzoheteroles0 aVisiblelightinduced radical sulfonylativecyclization cascade of  cOCT 0 v1710a110a6-Enynols10aBenzofurans10aBenzothiophenes10aindoles10aSulfones1 aKumari, Arram, Haritha1 aKumar, Jangam, Jagadesh1 aSharadha, Nunavath1 aKrishna, Gamidi, Rama1 aReddy, Raju, Jannapu uhttps://library.ncl.res.in/content/visible-light-induced-radical-sulfonylative-cyclization-cascade-16-enynol-derivatives