01477nas a2200205   4500008004100000022001400041245011000055210006900165260011000234300001600344490000700360520061100367100003200978700002701010700003401037700001501071700003701086700002501123856012301148       2015                        eng d  a1359-734500aAssessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections0 aAssessing the effect of different shapes of glycogold nanopartic  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAUG  a15669-156720 v513 a<p>Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.</p>1 aChaudhary, Preeti, Madhukar1 aSangabathuni, Sivakoti1 aMurthy, Raghavendra, Vasudeva1 aPaul, Ajay1 aThulasiram, Hirekodathakallu, V.1 aKikkeri, Raghavendra  uhttps://library.ncl.res.in/content/assessing-effect-different-shapes-glyco-gold-nanoparticles-bacterial-adhesion-and-001137nas a2200205   4500008004100000022001400041245009200055210006900147260011000216300001400326490000700340520032800347100001800675700001500693700002000708700002200728700003700750700002500787856011900812       2015                        eng d  a1359-734500aSupramolecular scaffolds on glass slides as sugar based rewritable sensors for bacteria0 aSupramolecular scaffolds on glass slides as sugar based rewritab  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a6346-63490 v513 a<p>We describe here the sugar functionalized beta-cyclodextrin-ferrocene glass slides as fully reversible bacterial biosensors under the influence of external adamantane carboxylic acid. The prototype D-mannose - E. coli ORN 178 and L-fucose - P. aeruginosa interactions serve as a model to illustrate the new approach.</p>1 aGade, Madhuri1 aPaul, Ajay1 aAlex, Catherine1 aChoudhury, Devika1 aThulasiram, Hirekodathakallu, V.1 aKikkeri, Raghavendra  uhttps://library.ncl.res.in/content/supramolecular-scaffolds-glass-slides-sugar-based-rewritable-sensors-bacteria-001162nas a2200193   4500008004100000245007600041210006900117260000800186300001400194490000700208520049700215100002300712700001900735700001500754700002400769700003000793700003700823856010800860       2018                        eng d00aLipase catalyzed synthesis of antimicrobial andrographolide derivatives0 aLipase catalyzed synthesis of antimicrobial andrographolide deri  cJUN  a1134-11410 v183 aIn this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide.1 aPatil, Harshal, S.1 aJadhav, Dipesh1 aPaul, Ajay1 aMulani, Fayaj, Alam1 aKaregaonkar, Shrikant, J.1 aThulasiram, Hirekodathakallu, V.  uhttps://library.ncl.res.in/content/lipase-catalyzed-synthesis-antimicrobial-andrographolide-derivatives01927nas a2200289   4500008004100000022001400041245009800055210006900153260000900222300001400231490000700245520098200252653001401234653002001248653002701268653001701295653001401312653001101326653002001337100002301357700002301380700001501403700002201418700003001440700003701470856013001507       2018                        eng d  a0960-894X00aRegioselective and efficient enzymatic synthesis of antimicrobial andrographolide derivatives0 aRegioselective and efficient enzymatic synthesis of antimicrobia  cAPR   a1132-11370 v283 a<p>Labdane diterpene andrographolide (1) is a major constituent of Andrographis paniculata and known to exhibit wide spectrum of biological activities. In this study, regioselective monoesters of (1) have been synthesized by using Amano lipase AK (Pseudomonas fluorescens) as a biocatalyst. Amano lipase AK was able to execute highly efficient esterification of hydroxyl group attached to C-14 carbon of (1) in presence of acyl donors. Among the various synthesized derivatives including two novel compounds such as andrographolide-14-propionate (3) and andrographolide-14-caproate (5) displayed antimicrobial activity against Staphylococcus aureus with low minimal inhibitory concentration (MIC) 4 mu g/mL and 16 mu g/mL respectively. Furthermore, they have shown low hemolysis activity at their respective MIC and increase in the permeability of the bacterial cell membrane as delineated by FITC uptake and SEM imaging studies. (C) 2018 Elsevier Ltd. All rights reserved.</p>10aAcylation10aAndrographolide10aAntimicrobial activity10abiocatalysis10aHemolysis10aLipase10aNatural product1 aPatil, Harshal, S.1 aJadhav, Dipesh, D.1 aPaul, Ajay1 aMulani, Fayaj, A.1 aKaregaonkar, Shrikant, J.1 aThulasiram, Hirekodathakallu, V.  uhttps://library.ncl.res.in/content/regioselective-and-efficient-enzymatic-synthesis-antimicrobial-andrographolide-derivatives