02395nas a2200205   4500008004100000020001400041245019500055210006900250260000800319520162100327100002101948700001901969700002301988700003002011700002302041700002802064700002302092700002702115856004702142       2022                        eng d  a2522-574X00aOne-pot concurrent biosynthesis of biphasic CuxO (cuprous and cupric oxide) nanoparticles using leaf extract of Eichhornia crassipes and investigation of their potent healthcare applications0 aOnepot concurrent biosynthesis of biphasic CuxO cuprous and cupr  cFEB3 aEichhornia crassipes, an aquatic weed, has been used for the one-pot quick synthesis of cuprous and cupric oxide nanoparticles in this report. The identification and validation of the formed nanoparticles were successfully done by sophisticated characterization techniques such as UV–visible spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. Their biomedical interventions were assessed by their antioxidant and anticancer activities. The synthesized nanoparticles have a spherical morphology with an average diameter of 10 nm. Antioxidant assay performed showed an increasing trend in a dose-dependent manner with the percentage radical scavenging activity up to 94.70% at a much higher concentration of 1000 µg/ml. The antioxidant potential at such higher concentration is suspected to invoke a change in the cytotoxic potential of the nanoparticles which is then verified by the MTT assay. A significant cytotoxic activity against HeLa (cervical cancer) and HCT 116 (colorectal carcinoma) cell lines was detected with noted IC50 values of 17.17 and 13.70 µg/ml respectively. The conclusive findings obtained are enough to substantiate the use of these nanoparticles in biomedical areas specifically in anticancer treatment due to their high toxicities. The hazards imposed by Eichhornia crassipes can be alleviated by using them as biofactories for the synthesis of a variety of nanomaterials. This helps in curbing the water pollution issues as well as the developing synthesis protocols for robust and stable nanoparticles.1 aMoudgil, Aliesha1 aVarma, Sanjana1 aShinde, Manish, D.1 aVamkudoth, Koteswara, Rao1 aSarkar, Dhiman, M.1 aShende, Rajnigandha, A.1 aAmalnerkar, Dinesh1 aChaudhari, Bhushan, P.  uhttps://doi.org/10.1007/s42247-022-00347-101851nas a2200217   4500008004100000022001400041245010800055210006900163260000800232300001500240490000600255520105700261653003101318653003501349653002501384653001801409653002201427100002801449700002701477856012901504       2023                        eng d  a2365-654900aRobust optimization and characterization of MCM-41 nanoparticle synthesis using modified sol-gel method0 aRobust optimization and characterization of MCM41 nanoparticle s  cMAR  ae2022049680 v83 a<p>
	Mesoporous silica nanoparticles (MSN) for drug delivery application requires great expertise to synthesize small sized monodisperse particles. We aimed at synthesizing and optimizing MCM-41 particles with the modified Stober's method by adjusting factors such as concentrations of cetyltrimethylammonium bromide (CTAB), sodium hydroxide (NaOH) and water (H2O) with respect to tetraethyl orthosilicate (TEOS), and a process parameter (stirring). We comprehended that the reactants determined the shape and size of both the particles and pores. Upon extensive characterization we report the synthesis of spherical particles of similar to 70 nm size in a monodisperse population; the structures had hexagonal ordered pores of diameter 3.071 nm and volume 3.124 cm(3)/g; the total surface area of 3410.648 m(2)/g of the particles was covered with silanol groups that aid in functionalization; the particles exhibited great thermal stability. Thus, the extensive optimization fabricated robust MCM-41 particles fit for drug delivery application.</p>
10acharacterization technique10adynamic light scattering (DLS)10amesoporous materials10aNanoparticles10asol gel processes1 aShende, Rajnigandha, A.1 aChaudhari, Bhushan, P.  uhttps://library.ncl.res.in/content/robust-optimization-and-characterization-mcm-41-nanoparticle-synthesis-using-modified-sol