01485nas a2200145   4500008004100000245010000041210006900141260000800210300001200218490000700230520093700237100002001174700002301194856012201217       2021                        eng d00aReview on liquid chromatographic analysis of colchicine in the forensic and medical perspective0 aReview on liquid chromatographic analysis of colchicine in the f  cDEC  a276-2870 v333 aColchicine is a tricyclic alkaloid extracted from the family of plants called Colchicaceae. Colchicine is pharmacologically active and works as an anti-mitotic agent. The alkaloid has a narrow therapeutic index, and a slight increase in colchicine concentration can lead to toxicity, and an overdose can be fatal to the individual. This nature of the alkaloid has made the scientific community interested in the analysis of colchicine. This critical review mainly comprises an analytical overview of the extraction and the liquid chromatographic (LC) analysis of colchicine in the field of forensic and medical toxicology. The prominent extraction techniques, detectors, and liquid chromatographic parameters favorable for colchicine estimation have been discussed in this paper. This review has covered the relevant research works within a timeline of two decades based on the scope of the literature and the scientific importance.1 aKrishna, Rohith1 aShivankar, Bhavana  uhttps://library.ncl.res.in/content/review-liquid-chromatographic-analysis-colchicine-forensic-and-medical-perspective00945nas a2200253   4500008004100000022001400041245013300055210006900188260000900257300001600266490000700282653001700289653003200306653003400338100003400372700002400406700002100430700002300451700002600474700002100500700002300521700003000544856011700574       2024                        eng d  a1944-824400aSynergistic effect of lactam and pyridine nitrogen on polysulfide chemisorption and electrocatalysis in lithium sulfur batteries0 aSynergistic effect of lactam and pyridine nitrogen on polysulfid  cAUG   a42059-420680 v1610aLi-S battery10aphenyl-diketopyrrolopyrrole10apyridine-diketopyrrolopyrrole1 aJavaregowda, Bharathkumar, H.1 aKargude, Radhakisan1 aBirajdar, Sarika1 aShivankar, Bhavana1 aKrishnamurty, Sailaja1 aJones, Lathe, A.1 aCaruso, Rachel, A.1 aKrishnamoorthy, Kothandam  uhttps://library.ncl.res.in/content/synergistic-effect-lactam-and-pyridine-nitrogen-polysulfide-chemisorption-and02001nas a2200253   4500008004100000022001400041245015400055210007000209260000900279300001600288490000700304520110100311100002401412700001801436700001701454700002001471700002301491700002001514700001901534700002301553700002101576700002201597856012801619       2025                        eng d  a0022-262300aDual agonist/antagonist modulation of α9-containing nicotinic acetylcholine receptors by 2-ammoniumethyl ethers of stilbenol and stilbenol analogues0 aDual agonistantagonist modulation of α9containing nicotinic acet  cDEC   a26099-261200 v683 a<p>
	2-(Cyclohexyldimethylammoniumethyl)ether of 4-stilbenol (2), and its styryl-modified analogues 21 and 22, were identified as lead compounds from a series targeting human alpha 9 alpha 10, alpha 9, and alpha 7 nicotinic acetylcholine receptors (nAChRs). Compounds 2 and 21 exhibited potent, and subtype-selective modulation of alpha 9-containing receptors, with low nanomolar IC50 values and dual agonist/antagonist activity in a concentration-dependent manner. In contrast, compound 22 acted as a selective, pure antagonist. Molecular dynamics (MD) simulations of compound 21 supported a concentration-dependent allosteric mechanism, with orthosteric binding at low concentrations and vestibular site interaction at higher levels. In a human monocytic cell line, all three compounds inhibited ATP-induced IL-1 beta release at nanomolar concentrations. These findings identify alpha 9 alpha 10-selective ligands as promising scaffolds for the development of nonopioid analgesics and immunomodulators, with favorable selectivity over alpha 7 nAChRs to minimize CNS-related side effects.</p>
1 aGiraudo, Alessandro1 aTae, Han-Shen1 aHung, Andrew1 aRichter, Katrin1 aShivankar, Bhavana1 aArmano, Edoardo1 aGrau, Veronika1 aPallavicini, Marco1 aAdams, David, J.1 aBolchi, Cristiano  uhttps://library.ncl.res.in/content/dual-agonistantagonist-modulation-%CE%B19-containing-nicotinic-acetylcholine-receptors-2