02608nas a2200157 4500008004100000245008700041210006900128260000800197300001400205490000700219520209600226100001702322700002202339700002502361856006402386 2024 eng d00aSynthesis of pyrazole and 1,3,4-oxadiazole derivatives of pharmaceutical potential0 aSynthesis of pyrazole and 134oxadiazole derivatives of pharmaceu cAug a127–1350 v223 a

Heterocyclic compounds are important molecules that serve as scaffolds or linkers for the core structure of numerous drug substances. In particular, pyrazole and 1,3,4-oxadiazole are compounds of great interest due to their comprehensive biological activities and interesting structural features. Here, we described an efficient and economical synthetic route leading to N-phenyl substituted pyrazole and 1,3,4-oxadiazole derivatives. Retrosynthetic disconnective analysis showed that the N-phenyl substituted pyrazole can be obtained from chalcone, accessible from the respective aldehyde, and acetophenone. The disubstituted 1,3,4-oxadiazole can be constructed from the respective aldehyde, which originates from pyrrole-containing compound, and formyl chloride. Based on our retrosynthetic analysis, N-phenyl substituted pyrazole was obtained by cyclization of the respective chalcone with phenylhydrazine to give pyrazoline which was in turn converted into pyrazole by oxidative aromatization. Potassium carbonate and a catalytic amount of molecular iodine were used to oxidatively cyclize semicarbazones into 1,3,4-oxadiazoles in a transition metal-free process. Novel pyrazole and 1,3,4-oxadiazoles with potential biological activity are investigated as antituberculosis, anticonvulsant, antidiabetic, anticancer, and tyrosinase inhibitory agents.

1 aKadam, Mayur1 aJadhao, Nitin, L.1 aGajbhiye, Jayant, M. uhttps://prospects.wum.edu.pl/index.php/pps/article/view/23501605nas a2200301 4500008004100000245009700041210006900138260000800207300001100215490000700226520064600233653001700879653001500896653001200911653001400923653001400937100002200951700002300973700002500996700002401021700002301045700002601068700002201094700002501116700001601141700001801157856012801175 2024 eng d00aSynthesized novel chromogenic reagent and sensor: detection and identification of dichlorvos0 aSynthesized novel chromogenic reagent and sensor detection and i cMAY ae312170 v103 a

We developed a novel chromogenic reagent and sensor by selective approach, for the detection and identification of dichlorvos, which we tested with the thin layer chromatography method. For the first time, we reported in situ-generated glyoxal as a hydrolysis product, which then interacts with isoniazid to produce a yellow-colored cyclic compound. We used well-known spectroscopic techniques to confirm the chemical identity of the final product. We initially investigated the reaction using a variety of approaches, followed by attempts to establish the reaction mechanism using Density Functional Theory by Gaussian software.

10aDFT analysis10aDichlorvos10aGloyxal10aHydrazone10aIsoniazid1 aGedam, Ashwin, D.1 aKatiya, Manish, M.1 aDhonde, Madhukar, G.1 aGanorkar, Kapil, S.1 aThakare, Vijay, J.1 aMandlik, Prashant, R.1 aJadhao, Nitin, L.1 aGajbhiye, Jayant, M.1 aKumar, Ravi1 aVaval, Nayana uhttps://library.ncl.res.in/content/synthesized-novel-chromogenic-reagent-and-sensor-detection-and-identification-dichlorvos