01206nas a2200217   4500008004100000022001400041245014600055210006900201260010600270300001400376490000700390520030900397653001400706653001800720653002900738653001900767653002200786100002800808700002200836856013000858       2006                        eng d  a0040-403900aCu(OTf)(2) or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of alpha-aminonitriles0 aCuOTf2 or Et3Ncatalyzed threecomponent condensation of aldehydes  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a5759-57620 v473 a<p>Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing alpha-aminonitriles in excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.</p>10aaldehydes10aaminonitriles10amulticomponent reactions10aorganocatalyst10aStrecker reaction1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-or-et3n-catalyzed-three-component-condensation-aldehydes-amines-and-cyanides-high-001389nas a2200229   4500008004100000022001400041245017700055210006900232260010600301300001400407490000700421520044300428653002300871653002500894653001600919653002100935653001400956653001500970100002800985700002201013856012401035       2006                        eng d  a0040-402000aEnantioselective synthesis of (-)-cytoxazone and (+)-epi-cytoxazone, novel cytokine modulators via sharpless asymmetric epoxidation and L-proline catalyzed mannich reaction0 aEnantioselective synthesis of cytoxazone and epicytoxazone novel  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a5756-57620 v623 a<p>A short and efficient enantioselective synthesis of (-)-cytoxazone and its stereoisomer (+)-epi-cytoxazone, novel cytokine modulators, has been described with good yield and enantioselectivity. Ti-catalyzed Sharpless asymmetric epoxidation of allyl alcohol and L-proline catalyzed three-component Mannich reaction constitute the key steps in introducing stereogenicity into the molecule. (c) 2006 Elsevier Ltd. All rights reserved.</p>10aaminohydroxylation10aAsymmetric synthesis10aepoxidation10aMannich reaction10aOxidation10aOzonolysis1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-cytoxazone-and-epi-cytoxazone-novel-cytokine-modulators-000983nas a2200157   4500008004100000022001400041245012700055210006900182260010600251300001400357490000700371520027800378100002400656700002200680856012300702       2006                        eng d  a0957-416600aEnantioselective synthesis of (S,S)-ethambutol using proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination0 aEnantioselective synthesis of SSethambutol using prolinecatalyze  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUL  a1738-17420 v173 a<p>An efficient enantioselective synthesis of (S,S)-ethambutol, a tuberculostatic antibiotic, has been achieved in 99% ee via both proline-catalyzed alpha-aminooxylation and alpha-amination of n-butyraldehyde as the key step. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aKotkar, Shriram, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-ss-ethambutol-using-proline-catalyzed-asymmetric-alpha-001355nas a2200193   4500008004100000022001400041245012800055210006900183260010600252300001400358490000700372520053300379100002600912700002300938700002200961700002600983700002501009856012701034       2006                        eng d  a0040-403900aNaIO4/KI/NaCl: a new reagent system for iodination of activated aromatics through in situ generation of iodine monochloride0 aNaIO4KINaCl a new reagent system for iodination of activated aro  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUL  a4793-47960 v473 a<p>A new reagent system consisting of NaIO4/KI/NaCl in aq AcOH has been found to be effective in iodinating a variety of activated aromatic substrates via in situ-generated iodine monochloride, to furnish iodoaromatics in excellent yields. This iodination procedure has been applied successfully for a cost-effective synthesis of 3,3'-diaminobenzidine, a key intermediate for preparing proton conducting membranes for fuel cell applications, with high yield and a purity of 99.7%. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aEmmanuvel, Lourdusamy1 aShukla, Ravi, Kant1 aSudalai, Arumugam1 aGurunath, Suryavanshi1 aSivaram, Swaminathan  uhttps://library.ncl.res.in/content/naio4kinacl-new-reagent-system-iodination-activated-aromatics-through-situ-generation-001267nas a2200169   4500008004100000022001400041245013200055210006900187260007100256300001400327490000700341520054200348100003200890700002600922700002200948856012700970       2006                        eng d  a0022-326300aNaIO4-mediated selective oxidation of alkylarenes and benzylic bromides/alcohols to carbonyl derivatives using water as solvent0 aNaIO4mediated selective oxidation of alkylarenes and benzylic br  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUN  a5043-50460 v713 a<p>A new transition-metal-free, sodium metaperiodate (NaIO4)-mediated direct oxidation of methylarenes and benzylic bromides to the corresponding aromatic carboxylic acids is described. Under the same reaction conditions, benzylic alcohols are selectively oxidized to afford the corresponding aldehydes in good yields without undergoing overoxidation. Unprecedentedly, oxidation of benzyl bromide, toluene, or benzyl alcohol with NaIO4 underwent nuclear bromination followed by oxidation to give 4-bromobenzoic acid in 60-79% yields.</p>1 aShaikh, Tanveer, Mahammad A1 aEmmanuvel, Lourdusamy1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4-mediated-selective-oxidation-alkylarenes-and-benzylic-bromidesalcohols-carbonyl-001111nas a2200157   4500008004100000022001400041245013300055210006900188260010600257300001400363490000700377520038700384100002900771700002200800856013100822       2006                        eng d  a0040-403900aShort and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric alpha-aminooxylation0 aShort and practical enantioselective synthesis of linezolid and   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a6799-68020 v473 a<p>An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using D-proline-catalyzed asymmetric alpha-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aNarina, Srinivasarao, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-and-practical-enantioselective-synthesis-linezolid-and-eperezolid-proline-catalyzed-000998nas a2200157   4500008004100000022001400041245013800055210006900193260010600262300001400368490000700382520027300389100002400662700002200686856013200708       2006                        eng d  a0040-403900aShort enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric alpha-aminooxylation0 aShort enantioselective synthesis of the antiepileptic agent leve  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a6813-68150 v473 a<p>An efficient enantioselective synthesis of a new antiepileptic drug, levetiracetam is described, in high optical purity (&gt; 99.5% ee), using proline-catalyzed alpha-aminooxylation of n-butyraldehyde as the key step. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aKotkar, Shriram, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-antiepileptic-agent-levetiracetam-based-proline-catalyzed-001095nas a2200229   4500008004100000022001400041245007900055210006900134260008900203300001200292490000700304520024300311653002300554653002700577653002900604653002800633653001500661653003300676100002800709700002200737856010600759       2007                        eng d  a0376-469900aCu(OTf)(2) catalyzed high yield synthesis of hantzsch 1,4-dihydropyridines0 aCuOTf2 catalyzed high yield synthesis of hantzsch 14dihydropyrid  aDR K S KRISHNAN MARG, NEW DELHI 110 012, INDIAbNATL INST SCIENCE COMMUNICATIONcFEB  a331-3350 v463 a<p>Copper(II) triflate catalyzes efficiently the three-component condensation of aldehydes, beta-ketoesters and ammonium acetate in acetonitrile at 25 degrees C to afford the corresponding Hantzsch 1,4-dihydropyridines in high yields.</p>10a4-dihydropyridines10aanti-hypertensive drug10acalcium channel blockers10acardiovascular diseases10aHantzsch 110athree-component condensation1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-catalyzed-high-yield-synthesis-hantzsch-14-dihydropyridines01028nas a2200157   4500008004100000022001400041245006700055210006600122260010600188300001400294490000700308520041800315100001800733700002200751856009700773       2007                        eng d  a0040-403900aEfficient organocatalytic route to the atorvastatin side-chain0 aEfficient organocatalytic route to the atorvastatin sidechain  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a8544-85460 v483 a<p>An organocatalytic route to the synthesis of the atorvastatin side-chain, a building block present in the statin family, is described using L-proline-catalyzed alpha-aminooxylation of an aldehyde. The method also employs an iodine-induced intramolecular electrophilic cyclization of a carbonate to produce the iodocarbonate in a highly diastereoselective manner. (C) 2007 Elsevier Ltd. All rights reserved.</p>1 aGeorge, Shyla1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/efficient-organocatalytic-route-atorvastatin-side-chain-001280nas a2200181   4500008004100000022001400041245013300055210006900188260010600257300001000363490000700373520049400380100002900874700002500903700001800928700002200946856013000968       2007                        eng d  a0040-403900aEnantioselective synthesis of (-)-cytoxazone and (+)-epi-cytoxazone via Rh-catalyzed diastereoselective oxidative C-H aminations0 aEnantioselective synthesis of cytoxazone and epicytoxazone via R  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a65-680 v483 a<p>An efficient enantioselective synthesis of (-)-cytoxazone (1) and (+)-epi-eytoxazone (2) using proline-catalyzed asymmetric alpha-amino-oxylation of aldehydes followed by Rh-catalyzed diastereoselective oxidative C-H amination as the key steps is described. syn or anti 1,2-aminoalcohols were obtained by Rh-catalyzed intramolecular amidation of the C-H bonds of carbamates or sulfamate esters with good to excellent diastereoselectivity. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aNarina, Srinivasarao, V.1 aKumar, Talluri, Siva1 aGeorge, Shyla1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-cytoxazone-and-epi-cytoxazone-rh-catalyzed-diastereoselective-001354nas a2200217   4500008004100000022001400041245012500055210006900180260010600249300001400355490000700369520050300376653002500879653001000904653001300914653002300927653001800950100002900968700002200997856011701019       2007                        eng d  a0040-402000aEnantioselective synthesis of (S)-timolol via kinetic resolution of terminal epoxides and dihydroxylation of allylamines0 aEnantioselective synthesis of Stimolol via kinetic resolution of  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR  a3026-30300 v633 a<p>An efficient enantioselective synthesis of (S)-timolol has been described using chiral Co-salen-catalyzed kinetic resolution of less expensive (+/-)-epichlorohydrin with 3-hydroxy-4-(N-morpholino)-1,2,5-thiadiazole in good overall yield (55%) and excellent enantioselectivity (98%). Synthesis of (S)-timolol has also been achieved using hydrolytic kinetic resolution as well as asymmetric dihydroxylation routes in 90% ee and 56% ee, respectively. (c) 2007 Elsevier Ltd. All rights reserved.</p>10aasymmetric reactions10adiols10aepoxides10aKinetic resolution10aoxazolidinone1 aNarina, Srinivasarao, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-s-timolol-kinetic-resolution-terminal-epoxides-and01106nas a2200229   4500008004100000022001400041245010500055210006900160260008600229300001400315490000700329520023100336653001900567653001800586653001900604653002000623653002500643100003200668700002600700700002200726856012800748       2007                        eng d  a0039-791100aNaIO4/LiBr-Mediated direct conversion of benzylic alcohols and aromatic aldehydes to aromatic esters0 aNaIO4LiBrMediated direct conversion of benzylic alcohols and aro  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcAUG  a2641-26460 v373 a<p>Aromatic aldehydes or benzylic alcohols are directly converted to the corresponding aromatic esters in high yields on treatment with methanol or ethanol mediated by sodium metaperiodate (NaIO4)/LiBr in an acidic medium.</p>10aaromatic ester10abenazaldehyde10aBenzyl alcohol10aLithium bromide10aSodium metaperiodate1 aShaikh, Tanveer, Mohammad A1 aEmmanuvel, Lourdusamy1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4libr-mediated-direct-conversion-benzylic-alcohols-and-aromatic-aldehydes-aromatic-001588nas a2200229   4500008004100000022001400041245016600055210006900221260010600290300001400396490000700410520065900417653003401076653001601110653001501126653001401141653001001155100001801165700002901183700002201212856012401234       2007                        eng d  a0040-403900aNaIO4-mediated asymmetric bromohydroxylation of alpha,beta-unsaturated carboxamides with high diastereoselectivity: a short route to (-)-cytoxazone and droxidopa0 aNaIO4mediated asymmetric bromohydroxylation of alphabetaunsatura  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a1375-13780 v483 a<p>The NaIO4-mediated asymmetric bromohydroxylation of alpha,beta-unsaturated carboxamides was achieved using lithium bromide as the bromine source under acidic conditions at rt to afford the corresponding chiral alpha-bromo-beta-hydroxy carboxamides. Excellent yields (77-90%) and diastereoselectivities (up to 10:1) along with exclusive control over regio- as well as anti-selectivity are the main features with a good scope of substrates. The method has successfully been applied in the enantioselective syntheses of two biologically important molecules, viz (-)-cytoxazone and L-threo-DOPS (droxidopa). (c) 2007 Elsevier Ltd. All rights reserved.</p>10aasymmetric bromohydroxylation10aCarboxamide10acytoxazone10adroxidopa10aNaIO41 aGeorge, Shyla1 aNarina, Srinivasarao, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4-mediated-asymmetric-bromohydroxylation-alphabeta-unsaturated-carboxamides-high00902nas a2200157   4500008004100000022001400041245008200055210006900137260010600206300001400312490000700326520025700333100002500590700002200615856010700637       2007                        eng d  a0040-402000aOrgano-catalytic approach to the enantioselective synthesis of (R)-selegiline0 aOrganocatalytic approach to the enantioselective synthesis of Rs  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a9758-97630 v633 a<p>An efficient enantioselective synthesis of (R)-selegiline has been achieved by two routes, via proline-catalyzed alpha-aminooxylation as well as alpha-amination of phenylpropanaldehyde as the key step. (c) 2007 Elsevier Ltd. All rights reserved.</p>1 aTalluri, Siva, Kumar1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/organo-catalytic-approach-enantioselective-synthesis-r-selegiline-001107nas a2200169   4500008004100000022001400041245016900055210006900224260007100293300001400364490000600378520035700384100002400741700002200765700002200787856012800809       2007                        eng d  a1523-706000aOrganocatalytic sequential alpha-amination-horner-wadsworth-emmons olefination of aldehydes: enantioselective synthesis of gamma-amino-alpha,beta-unsaturated esters0 aOrganocatalytic sequential alphaaminationhornerwadsworthemmons o  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR  a1001-10040 v93 a<p>A novel and highly enantioselective method for the synthesis of gamma-amino-alpha,beta-unsaturated esters via tandem alpha-amination-Horner-Wadsworth-Emmons (HWE) olefination of aldehydes is described. The one-pot assembly has been demonstrated for the construction of functionalized chiral 2-pyrrolidones, subunits present in several alkaloids.</p>1 aKotkar, Shriram, P.1 aChavan, Vilas, B.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/organocatalytic-sequential-alpha-amination-horner-wadsworth-emmons-olefination-aldehydes01176nas a2200193   4500008004100000022001400041245013100055210006900186260011700255300001200372520033500384653002100719653002500740653002000765653002000785100002600805700002200831856012900853       2007                        eng d  a1424-637600aPhosphine ligand and base-free, Pd-catalyzed oxidative cross-coupling reaction of arylboronic acids with arylmercuric acetates0 aPhosphine ligand and basefree Pdcatalyzed oxidative crosscouplin  aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcJAN  a126-1333 a<p>Arylmercuric acetates have been found to undergo Suzuki type cross coupling reactions with arylboronic acids catalyzed by palladium salts in non-polar solvents under ambient conditions to give biaryl derivatives in high yields. The reaction is mild and does not require any organic or inorganic base nor a phosphine ligand.</p>10aArylboronic acid10aarylmercuric acetate10apalladium salts10aSuzuki coupling1 aEmmanuvel, Lourdusamy1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/phosphine-ligand-and-base-free-pd-catalyzed-oxidative-cross-coupling-reaction-arylboronic01091nas a2200157   4500008004100000022001400041245012300055210006900178260010600247300001400353490000700367520038500374100002200759700002200781856013000803       2008                        eng d  a0040-403900aCo-catalyzed mild and chemoselective reduction of phenyl esters with NaBH(4): a practical synthesis of (R)-tolterodine0 aCocatalyzed mild and chemoselective reduction of phenyl esters w  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a3790-37930 v493 a<p>CoCl(2) catalyzes effectively the chemoselective reduction of phenyl carboxylic esters to the corresponding saturated alcohols in high yields using NaBH(4) at ambient conditions. By employing this methodology, the synthesis of (R)-tolterodine, a muscarinic receptor antagonist, has been achieved in high yield and optical purity. (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aJagdale, Arun, R.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/co-catalyzed-mild-and-chemoselective-reduction-phenyl-esters-nabh4-practical-synthesis-r-001180nas a2200217   4500008004100000022001400041245014300055210006900198260010300267300001400370490000700384520030400391653001400695653001400709653001100723653002800734100002200762700002800784700002200812856012800834       2008                        eng d  a0376-469900aCu(OTf)(2) catalyzed Biginelli type condensation of aldehydes, beta-keto esters and carbamates: synthesis of 3,4-dihydro[1,3]oxazin-2-ones0 aCuOTf2 catalyzed Biginelli type condensation of aldehydes betake  aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScJUL  a1091-10950 v473 a<p>Cu(OTf)(2) catalyzes effectively a new multicomponent reaction comprising aldehydes, beta-ketoester and methy carbamate in acetonitrile to afford substituted 3,4-dihydro[1,3]oxazin-2-ones in 60-82% yields. These compounds have been found to show inhibition activity against HL-60 cancer cell.</p>10aaldehydes10aCatalysts10aCopper10aMulticomponent reaction1 aJagdale, Arun, R.1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-catalyzed-biginelli-type-condensation-aldehydes-beta-keto-esters-and-carbamates-001109nas a2200217   4500008004100000022001400041245008400055210006900139260010600208300001400314490000700328520031200335653001100647653001900658653001500677653001000692100003200702700002600734700002200760856010900782       2008                        eng d  a0040-403900aNaIO4-KI-NaN3 as a new reagent system for C-H functionalization in hydrocarbons0 aNaIO4KINaN3 as a new reagent system for CH functionalization in   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6401-64030 v493 a<p>The NaIO4-KI-NaN3 combination has been found to be an efficient, reliable, and inexpensive reagent system for mono- and 1,2-difunctionalization of hydrocarbons via C-H bond activation to afford vicinal azido- and acetoxy iodinations of cyclic hydrocarbons. (C) 2008 Elsevier Ltd. All rights reserved.</p>10aazides10aC-H activation10aIodination10aNaIO41 aChouthaiwale, Pandurang, V.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4-ki-nan3-new-reagent-system-c-h-functionalization-hydrocarbons-001185nas a2200169   4500008004100000022001400041245010800055210006900163260010600232300001400338490000700352520045800359100001800817700003000835700002200865856012800887       2008                        eng d  a0040-403900aShort enantioselective synthesis of (-)-bestatin via L-proline-catalyzed alpha-amination of an aldehyde0 aShort enantioselective synthesis of bestatin via Lprolinecatalyz  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6791-67930 v493 a<p>A short and high yielding enantioselective synthesis of (-)-bestatin, a naturally occurring aminopeptidase inhibitor, is described Via L-proline-catalyzed asymmetric alpha-amination of 3-phenylpropionaldehyde as the key reaction. The methodology also involves a Pd-catalyzed intramolecular cyclization of an allylic acetate giving a trans-oxazoline in a highly diastereoselective manner (dr &gt; 14:1). (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aGeorge, Shyla1 aSuryavanshi, Gurunath, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-bestatin-l-proline-catalyzed-alpha-amination-aldehyde-001268nas a2200229   4500008004100000022001400041245010300055210006900158260010600227300001400333490000700347520041000354653000600764653002000770653000600790653003200796653002700828653001200855100002600867700002200893856012300915       2008                        eng d  a0040-403900aShort enantioselective synthesis of (+)-L-733,060 via Shi epoxidation of a homoallylic carboxylate0 aShort enantioselective synthesis of L733060 via Shi epoxidation   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a5736-57380 v493 a<p>A short and efficient enantioselective synthesis of (+)-L-733,060 in 92% ee via Shi epoxidation of a homoallylic carboxylate is described. Johnson-Claisen rearrangement was employed to obtain the required carbon backbone, whilst intramolecular reductive O-to-N-ring expansion of a delta-azidolactone was used in the construction of the piperidine moiety. (C) 2008 Elsevier Ltd. All rights reserved.</p>10a110a2-aminoalcohols10a310a3-sigmatropic rearrangement10aasymmetric epoxidation10aLactone1 aEmmanuvel, Lourdusamy1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-l-733060-shi-epoxidation-homoallylic-carboxylate-001254nas a2200205   4500008004100000022001400041245015000055210006900205260007600274300001400350520043300364653001100797653001800808653001200826653001400838653001300852100003200865700002200897856012900919       2008                        eng d  a1434-193X00aWO3/70% TBHP/aqueous NaOH: an efficient catalytic combination for the selective oxidation of methylarenes and alkyl aryl ketones to benzoic acids0 aWO370 TBHPaqueous NaOH an efficient catalytic combination for th  aCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAbWILEY-BLACKWELLcOCT  a4877-48803 a<p>A new solvent-free, reusable catalytic combination consisting Of WO3/70% TBHP/aqueous NaOH has been described for the direct oxidation of methylarenes and acetophenones to the corresponding benzoic acids in high yields. Alkylarenes are oxidized to the corresponding aromatic ketones or benzylic alcohols depending upon whether NaOH is used or not. ((C) Wiley-VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)</p>10aArenes10aBenzoic acids10aKetones10aOxidation10aTungsten1 aShaikh, Tanveer, Mahammad A1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/wo370-tbhpaqueous-naoh-efficient-catalytic-combination-selective-oxidation-methylarenes-001082nas a2200169   4500008004100000022001400041245013100055210006900186260007100255300001200326490000700338520037200345100002200717700002000739700002200759856013100781       2009                        eng d  a1523-706000aAsymmetric synthesis of tetrahydroquinolin-3-ols via CoCl2-catalyzed reductive cyclization of nitro cyclic sulfites with NaBH40 aAsymmetric synthesis of tetrahydroquinolin3ols via CoCl2catalyze  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a803-8060 v113 a<p>A new method for the construction of chiral 3-substituted tetrahydroquinoline derivatives based on asymmetric dihydroxylation and CoCl2-catalyzed reductive, cyclization of nitro cyclic sulfites with NaBH4 has been described with high optical purities. This method has been successfully applied in the formal synthesis of PNU 95666E and anachelin H chromophore.</p>1 aJagdale, Arun, R.1 aReddy, Santhosh1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/asymmetric-synthesis-tetrahydroquinolin-3-ols-cocl2-catalyzed-reductive-cyclization-nitro-001309nas a2200217   4500008004100000022001400041245014200055210006900197260007500266300001200341520047000353653001300823653001100836653001400847653001100861653001500872100002200887700002800909700002200937856013200959       2009                        eng d  a0039-788100aCobalt(II) chloride hexahydrate-diisopropylamine catalyzed mild and chemoselective reduction of carboxylic esters with sodium borohydride0 aCobaltII chloride hexahydratediisopropylamine catalyzed mild and  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcFEB  a660-6643 a<p>The cobalt-catalyzed reduction of unsaturated alpha-cyano carboxylic esters using sodium borohydride (NaBH(4)) leads to the corresponding saturated cyano alcohols in high yields. In particular, the new catalytic system cobalt(II) chloride-diisopropylamine in combination with NaBH(4) showed excellent activity in the chemoselective reduction of a variety of carboxylic esters to their corresponding alcohols in good to excellent yields under mild conditions.</p>10aAlcohols10aamines10acatalysis10aEsters10areductions1 aJagdale, Arun, R.1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cobaltii-chloride-hexahydrate-diisopropylamine-catalyzed-mild-and-chemoselective-reduction-001096nas a2200181   4500008004100000022001400041245015800055210006900213260010600282300001400388490000700402520027900409100001700688700003200705700002600737700002200763856012900785       2009                        eng d  a0957-416600aConcise enantioselective synthesis of (+)-decarestrictine L via proline-catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination0 aConcise enantioselective synthesis of decarestrictine L via prol  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a2173-21770 v203 a<p>A short enantioselective synthesis of (+)-decarestrictine L, a cholesterol biosynthesis inhibitor metabolite, is described using a D-proline catalyzed sequential alpha-aminooxylation and a Horner-Wadsworth-Emmons olefination. (C) 2009 Elsevier Lid All rights reserved</p>1 aRawat, Varun1 aChouthaiwale, Pandurang, V.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-decarestrictine-l-proline-catalyzed-sequential-alpha-001062nas a2200169   4500008004100000022001400041245005800055210005400113260010600167300001000273490000700283520044100290100002600731700002500757700002200782856008800804       2009                        eng d  a0957-416600aConcise enantioselective synthesis of (+)-febrifugine0 aConcise enantioselective synthesis of febrifugine  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a84-880 v203 a<p>A short enantioselective synthesis of (+)-febrifugine, a potent antimalarial alkaloid, has been described based on the regioselective asymmetric dihydroxylation of a 1,4-dienic ester as the key step. The strategy also involves chemoselective [3,3]-sigmatropic rearrangement of 1,5-hexadiene-3-ol and intramolecular lactamization of azidolactone for the construction of piperidine core. (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aEmmanuvel, Lourdusamy1 aKamble, Dayanand, A.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-febrifugine-000968nas a2200157   4500008004100000022001400041245006000055210005600115260010600171300001400277490000700291520036800298100003200666700002200698856009000720       2009                        eng d  a0957-416600aConcise enantioselective synthesis of (+)-lentiginosine0 aConcise enantioselective synthesis of lentiginosine  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a2287-22920 v203 a<p>A high yielding enantioselective synthesis of the indolizidine alkaloid, (+)-lentiginosine, has been described based on asymmetric oza-Cope rearrangement and the L-proline catalyzed alpha-aminooxylation of aldehydes. The strategy also makes use of ring-closing metathesis for the construction of piperidine core. (C) 2009 Elsevier Ltd. All rights reserved.</p>1 aShaikh, Tanveer, Mahamadali1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-lentiginosine-001191nas a2200241   4500008004100000022001400041245012000055210006900175260010300244300001400347490000700361520029300368653001600661653001300677653001700690653001600707653001100723653001500734100002200749700003200771700002200803856012400825       2009                        eng d  a0376-469900aCu(OTf)(2)-catalyzed alpha-halogenation of ketones with 1,3-dichloro-5,5 `-dimethylhydantoin and N-bromosuccinimide0 aCuOTf2catalyzed alphahalogenation of ketones with 13dichloro55 d  aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScOCT  a1424-14300 v483 a<p>Copper(II) triflate catalyses efficiently the alpha-halogentation of aryl or alkyl ketones with 1,3-dichloro-5,5'-dimethyl-hydantoin and N-bromosaccinimde to give the corresponding alpha,alpha-dichloroketones and alpha-bromoketones in high yield with excellent product selectivity.</p>10aBromination10aCatalyst10achlorination10acopper (II)10aKetone10aLewis acid1 aJagdale, Arun, R.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-catalyzed-alpha-halogenation-ketones-13-dichloro-55-dimethylhydantoin-and-n-001080nas a2200217   4500008004100000022001400041245005900055210005500114260011700169300001000286520031600296653002000612653002400632653001500656653001600671653001200687100003200699700002400731700002200755856008500777       2009                        eng d  a1424-637600aFormal synthesis of (-) anisomycin via organocatalysis0 aFormal synthesis of anisomycin via organocatalysis  aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcJAN  a88-943 a<p>An efficient formal synthesis of (-) anisomycin (1), a potent antibiotic agent, has been achieved in good yields and excellent diastereoselectivity. The key steps are proline-catalyzed sequential alpha-amination or alpha-aminoxylation of aldehyde 2 followed by tandem Horner-Wadsworth-Emmons olefination.</p>10aalpha-Amination10aalpha-aminoxylation10aanisomycin10aolefination10aProline1 aChouthaiwale, Pandurang, V.1 aKotkar, Shriram, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/formal-synthesis-anisomycin-organocatalysis-001414nas a2200241   4500008004100000022001400041245009900055210006900154260010600223300001400329490000700343520046900350653003000819653001900849653002300868653002500891653002400916100003200940700002600972700002600998700002201024856012601046       2009                        eng d  a0040-403900aTitanium superoxide: a heterogeneous catalyst for anti-Markovnikov aminobromination of olefins0 aTitanium superoxide a heterogeneous catalyst for antiMarkovnikov  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a2815-28170 v503 a<p>A new facile procedure for the aminobromination of olefins in high yields has been described using p-toluene sulfonamide (p-TsNH(2)) and N-bromosuccinimide (NBS) as introgen and bromine sources, respectively, and titanium superoxide as a truly heterogeneous catalyst. The formation of anti-Markovnikov product exclusively in all the cases studied possibly proceeding I free radical reaction pathway is remarkable. (C) 2009 Elsevier Ltd. All rights reserved.</p>10aanti-Markovnikov addition10aBromoamination10aN-Bromosuccinimide10ap-Toluenesulfonamide10aTitanium superoxide1 aShaikh, Tanveer, Mahamadali1 aKarabal, Pratibha, U.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/titanium-superoxide-heterogeneous-catalyst-anti-markovnikov-aminobromination-olefins-001248nas a2200193   4500008004100000022001400041245016300055210006900218260011000287300001400397490000700411520039500418100002000813700003200833700002600865700002200891700002200913856011900935       2010                        eng d  a1359-734500aCo(III)(salen)-catalyzed HKR of two stereocentered alkoxy- and azido epoxides: a concise enantioselective synthesis of (S,S)-reboxetine and (+)-epi-cytoxazone0 aCoIIIsalencatalyzed HKR of two stereocentered alkoxy and azido e  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN  a5012-50140 v463 a<p>The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S, S)-reboxetine and (+)-epi-cytoxazone.</p>1 aReddy, Santhosh1 aChouthaiwale, Pandurang, V.1 aSuryavanshi, Gurunath1 aChavan, Vilas, B.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/coiiisalen-catalyzed-hkr-two-stereocentered-alkoxy-and-azido-epoxides-concise-001154nas a2200205   4500008004100000022001400041245011600055210006900171260007600240300001400316520034800330653001400678653001600692653001900708653002300727653002000750100003200770700002200802856012400824       2010                        eng d  a1434-193X00aEnantioselective synthesis of (+)-alpha-conhydrine and (-)-sedamine by L-proline-catalysed alpha-aminooxylation0 aEnantioselective synthesis of alphaconhydrine and sedamine by Lp  aCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAbWILEY-BLACKWELLcJUN  a3437-34443 a<p>An efficient organocatalytic approach to the enantioslective synthesis of two important piperidine alkaloids, namely (+)-alpha-conhydrine (98% ee) and (-)-sedamine (95% ee), by L-proline-catalysed alpha-aminooxylation of aldehydes has been developed. The strategy involves an intramolecular cyclization to construct the piperidine core.</p>10aalkaloids10aAmino acids10aAminooxylation10aEnantioselectivity10aorganocatalysis1 aShaikh, Tanveer, Mahamadali1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-alpha-conhydrine-and-sedamine-l-proline-catalysed-alpha-001569nas a2200253   4500008004100000022001400041245019000055210006900245260010600314300001400420490000700434520053900441653002000980653002501000653002401025653001801049653001201067100001701079700003201096700002201128700002601150700002201176856011701198       2010                        eng d  a0040-403900aFacile enantioselective synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol via proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination of aldehyde0 aFacile enantioselective synthesis of SN5chlorothiophene2sulfonyl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a6565-65670 v513 a<p>A high-yielding enantioselective synthesis of the bioactive (S)-N-(5-chlorothiophene-2-sulfonyl)beta,beta-diethylalaninol (1), a Notch-1-sparing gamma-secretase inhibitor metabolite (with EC50 = 28 nM) effective in reduction of All production in vivo, has been realized starting from readily available 3-pentanone. The key steps of the synthesis are proline-catalyzed alpha-aminooxylation and alpha-amination of aldehyde: the latter contributing an overall yield of 45.2% and 98% ee. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aalpha-Amination10aalpha-Aminooxylation10aAlzheimer's disease10aAmino alcohol10aProline1 aRawat, Varun1 aChouthaiwale, Pandurang, V.1 aChavan, Vilas, B.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/facile-enantioselective-synthesis-s-n-5-chlorothiophene-2-sulfonyl-betabeta-001149nas a2200217   4500008004100000022001400041245009900055210006900154260007700223300001200300490000700312520034600319653001300665653001900678653002700697653001200724100002200736700003200758700002200790856011900812       2010                        eng d  a1318-020700aH-beta zeolite: an efficient, reusable catalyst for one-pot synthesis of isatins from anilines0 aHbeta zeolite an efficient reusable catalyst for onepot synthesi  aHAJDRIHOVA 19, LJUBLJANA 1000, SLOVENIAbSLOVENSKO KEMIJSKO DRUSTVOcJUN  a466-4690 v573 a<p>We describe a simple and highly efficient procedure for the single-step preparation of isatins from the commercially available anilines using H-beta zeolite as a truly heterogeneous catalyst. H-beta zeolite is readily separated from reaction mixture by simple filtration and reused several times without considerable loss of activity.</p>10aAnilines10aH-beta zeolite10aheterogeneous catalyst10aisatins1 aRaj, Victor, Paul1 aShaikh, Tanveer, Mahamadali1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/h-beta-zeolite-efficient-reusable-catalyst-one-pot-synthesis-isatins-anilines-001343nas a2200253   4500008004100000022001400041245006800055210006500123260010600188300001400294490000700308520045200315653001800767653001700785653002000802653001100822653002500833100002600858700003200884700002400916700002600940700002200966856010100988       2010                        eng d  a0040-403900aNaIO4/LiBr-mediated aziridination of olefins using chloramine-T0 aNaIO4LiBrmediated aziridination of olefins using chloramineT  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a6460-64620 v513 a<p>A new milder protocol for aziridination of a variety of olefins has been described. The process employs catalytic amount of sodium metaperiodate (NaIO4) as an oxidant and LiBr and chloramine-T as the bromine and nitrogen sources, respectively. Interestingly, the formation of aziridine products in all the cases studied takes place presumably through a process of 1,2-aminobromination of alkenes. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aAziridination10aChloramine-T10aLithium bromide10aOlefin10aSodium metaperiodate1 aKarabal, Pratibha, U.1 aChouthaiwale, Pandurang, V.1 aShaikh, Tanveer, M.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4libr-mediated-aziridination-olefins-using-chloramine-t-001679nas a2200277   4500008004100000022001400041245011500055210006900170260007500239300001000314490000700324520067300331653002201004653002101026653002701047653001401074653002401088100002001112700003201132700001701164700002601181700002001207700002601227700002201253856012601275       2010                        eng d  a1571-101300aNovel synthesis and characterization of titanium superoxide and its application in organic oxidative processes0 aNovel synthesis and characterization of titanium superoxide and   a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGER/PLENUM PUBLISHERScMAR  a21-320 v143 a<p>A novel, exceptionally stable titanium superoxide radical ion was prepared and its structure determined by FTIR, ESR, Raman spectroscopy, X-ray diffraction, thermogravimetric/differential thermal analysis and elemental analysis. This heterogeneous catalyst has been found to be effective for the selective oxidation of aromatic amines and phenols to the corresponding nitro aromatics and p-quinones, respectively. In addition, this non-toxic, inexpensive and reusable catalyst has also been used in aminobromination of olefins, which proceed to give the 1, 2-bromoaminated anti-Markovnikov product. A brief account of these results is summarized in this review.</p>10aAmino Bromination10aAnti-Markovnikov10aheterogeneous catalyst10aOxidation10aTitanium superoxide1 aReddy, Santhosh1 aShaikh, Tanveer, Mahamadali1 aRawat, Varun1 aKarabal, Pratibha, U.1 aDewkar, Gajanan1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/novel-synthesis-and-characterization-titanium-superoxide-and-its-application-organic-001222nas a2200229   4500008004100000022001400041245014600055210006900201260007500270300001400345520031500359653001200674653001100686653002000697653002000717653001900737100003200756700002600788700002600814700002200840856013000862       2010                        eng d  a0039-788100aRegiospecific azidoiodination of alkenes with sodium periodate, potassium iodide, and sodium azide: a high-yield synthesis of beta-iodoazides0 aRegiospecific azidoiodination of alkenes with sodium periodate p  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcNOV  a3879-38823 a<p>The combination of sodium periodate, potassium iodide, and sodium azide has been found to be an efficient, simple, and inexpensive reagent system for azidoiodination of alkenes. The regiospecific 1,2-azidoiodination proceeds in an anti-Markovnikov fashion to produce beta-iodoazides in excellent yields.</p>10aalkenes10aazides10aazidoiodination10abeta-iodoazides10aregio-specific1 aChouthaiwale, Pandurang, V.1 aKarabal, Pratibha, U.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/regiospecific-azidoiodination-alkenes-sodium-periodate-potassium-iodide-and-sodium-azide-001078nas a2200169   4500008004100000022001400041245008200055210006900137260010600206300001200312490000700324520039800331100001800729700002600747700002200773856011300795       2010                        eng d  a0957-416600aShort enantioselective synthesis of guggultetrol, a naturally occurring lipid0 aShort enantioselective synthesis of guggultetrol a naturally occ  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a558-5610 v213 a<p>An enantioselective synthesis of the naturally occurring lipid, guggultetrol, is described with an overall yield of 24% starting from commercially available 1-pentadecanol in ten linear steps. The key chiral-inducing steps include a Sharpless asymmetric epoxidation of allylic alcohol and a dihydroxylation of an alpha,beta-unsaturated ester. (C) 2010 Elsevier Ltd. All rights reserved.</p>1 aGeorge, Shyla1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-guggultetrol-naturally-occurring-lipid-001410nas a2200241   4500008004100000022001400041245016000055210006900215260010600284300001200390490000700402520041600409653001500825653002500840653003400865653002500899653001900924100002600943700002000969700002600989700002201015856013101037       2011                        eng d  a0040-403900aConcise enantioselective synthesis of (+)-goniodiol and (+)-8-methoxygoniodiol via Co-catalyzed HKR of anti-(2SR, 3RS)-3-methoxy-3-phenyl-1, 2-epoxypropane0 aConcise enantioselective synthesis of goniodiol and 8methoxygoni  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a438-4400 v523 a<p>A short, enantioselective synthesis of (+)-goniodiol and (+)-8-methoxygoniodiol, cytotoxic styryllactones, has been achieved in high optical purities (99% ee). The strategy employs Co-catalyzed HKR of racemic anti-(2SR, 3RS)-3-methoxy-3-phenyl-1,2-epoxypropane and Lewis acid-mediated diastereoselective allylation of aldehyde as chiral inducing key reactions. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aAllylation10adiastereoselectivity10aHydrolytic kinetic resolution10aRacemic anti-epoxide10aStyryllactones1 aKiran, I., N. Chaitha1 aReddy, Santhosh1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-goniodiol-and-8-methoxygoniodiol-co-catalyzed-hkr-anti-001239nas a2200181   4500008004100000022001400041245008700055210006900142260010600211300001400317490000700331520052600338100002100864700001700885700002600902700002200928856010700950       2012                        eng d  a0957-416600aAsymmetric synthesis of (+)-stagonolide C and (-)-aspinolide A via organocatalysis0 aAsymmetric synthesis of stagonolide C and aspinolide A via organ  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a1534-15410 v233 a<p>A new enantioselective synthesis of two important fungal metabolites, (+)-stagonolide C and (-)-aspinolide A, has been described from readily available raw materials. Praline catalyzed asymmetric alpha-aminooxylation and Jorgensen's epoxidation of aldehydes are the key reactions employed in the introduction of chirality. The formation of the 10-membered lactone core structure was finally accomplished via Steglich esterification and ring closing metathesis reactions. (C) 2012 Elsevier Ltd. All rights reserved.</p>1 aShelke, Anil, M.1 aRawat, Varun1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/asymmetric-synthesis-stagonolide-c-and-aspinolide-organocatalysis-001196nas a2200169   4500008004100000022001400041245013300055210006900188260011000257300001400367490000700381520043900388100002000827700002600847700002200873856013100895       2012                        eng d  a1477-052000aCN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalides0 aCNassisted oxidative cyclization of cyano cinnamates and styrene  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a3655-36610 v103 a<p>The asymmetric dihydroxylation (AD) of o-cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD process. The method is amply demonstrated by the synthesis and the structural/stereochemical assignment of the natural products.</p>1 aReddy, Santhosh1 aKiran, I., N. Chaitha1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cn-assisted-oxidative-cyclization-cyano-cinnamates-and-styrene-derivatives-facile-entry-3-001248nas a2200205   4500008004100000022001400041245012600055210006900181260010600250300001400356490000700370520039300377653001800770653003400788653001500822653002300837100003000860700002200890856013000912       2012                        eng d  a0040-403900aConcise synthesis of (+)-deoxoprosophylline via Co(III)(salen)-catalyzed two stereocentered HKR of racemic azido epoxides0 aConcise synthesis of deoxoprosophylline via CoIIIsalencatalyzed   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a3213-32150 v533 a<p>An efficient synthesis of (+)-deoxoprosophylline has been achieved in high optical purity (99% ee) from readily available cis-2-butene-1,4-diol. The strategy employs Co-catalyzed Hydrolytic Kinetic Resolution (HKR) of two stereocentered racemic azido epoxides and diastereoselective intramolecular reductive cyclization as key reactions. (C) 2012 Elsevier Ltd. All rights reserved.</p>10aAzido epoxide10aHydrolytic kinetic resolution10aPiperidine10aWittig olefination1 aDevalankar, Dattatray, A.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-synthesis-deoxoprosophylline-coiiisalen-catalyzed-two-stereocentered-hkr-racemic-001422nas a2200253   4500008004100000022001400041245011600055210006900171260011000240300001400350490000700364520044900371653001700820653002600837653003000863653001800893653001400911653002600925100002300951700002200974700002000996700002201016856013001038       2012                        eng d  a0376-471000aCu-II-exchanged montmorillonite K10 clay-catalyzed direct carboxylation of terminal alkynes with carbon dioxide0 aCuIIexchanged montmorillonite K10 claycatalyzed direct carboxyla  aDR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIAbNATL INST SCIENCE COMMUNICATION-NISCAIRcSEP  a1325-13290 v513 a<p>A new, simple and straight-forward protocol for direct carboxylation of terminal alkynes has been developed using Cu-II-montmorillonite K10 clay as a heterogeneous catalyst and CO2 as the C1 carbon feedstock. Also coupling of terminal alkynes with CO2 (1 atm) in the presence of alkyl halides has been achieved under the same reaction conditions, thereby providing access to a variety of functionalized alkyl-2-alkynoates in high yields.</p>10aAlkyl esters10aAlkyne C-H activation10aCarbon dioxide activation10aCarboxylation10aCatalysts10aMontmorillonite clays1 aAher, Ravindra, D.1 aGade, Madhuri, H.1 aReddy, Santhosh1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cu-ii-exchanged-montmorillonite-k10-clay-catalyzed-direct-carboxylation-terminal-alkynes-001351nas a2200169   4500008004100000022001400041245012500055210006900180260010600249300001200355490000700367520061100374100002300985700002001008700002201028856013101050       2012                        eng d  a0957-416600aEnantioselective synthesis of HIV protease inhibitor amprenavir via Co-catalyzed HKR of 2-(1-azido-2-phenylethyl)oxirane0 aEnantioselective synthesis of HIV protease inhibitor amprenavir   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a898-9030 v233 a<p>A short and efficient enantioselective synthesis of the HIV protease inhibitor amprenavir 1 (99% ee) as well as a formal synthesis of saquinavir 3 have been achieved in high enantiomeric purity starting from commercially available materials. Our strategy mainly comprises a Co-catalyzed two-stereocentred hydrolytic kinetic resolution (HKR) of racemic 2-(1-azido-2-phenylethyl)oxirane as the chirality inducing step. Also presented is a concise synthesis of (S)-3-hydroxytetrahydrofuran 4, the key structural feature, in high enantiomeric purity (98% ee). (c) 2012 Elsevier Ltd. All rights reserved.</p>1 aGadakh, Sunita, K.1 aReddy, Santhosh1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-hiv-protease-inhibitor-amprenavir-co-catalyzed-hkr-2-1-azido-2-001271nas a2200241   4500008004100000022001400041245009400055210006900149260010600218300001400324490000700338520036200345653001200707653001700719653002100736653002100757653002100778100002500799700002600824700003200850700002200882856012500904       2012                        eng d  a0040-403900aNaIO4-NaN3-mediated diazidation of styrenes, alkenes, benzylic alcohols, and aryl ketones0 aNaIO4NaN3mediated diazidation of styrenes alkenes benzylic alcoh  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4195-41980 v533 a<p>Sodium periodate and sodium azide combination has been found to be an excellent reagent system suitable for the direct diazidation of styrenes, alkenes, benzylic alcohols, and aryl ketones to produce the corresponding vicinal and geminal diazides respectively in high yields under mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.</p>10aalkenes10aAryl ketones10aGeminal diazides10aSodium periodate10aVicinal diazides1 aKamble, Dayanand, A.1 aKarabal, Pratibha, U.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4-nan3-mediated-diazidation-styrenes-alkenes-benzylic-alcohols-and-aryl-ketones-001183nas a2200169   4500008004100000022001400041245014700055210006900202260007100271300001400342490000700356520044800363100001900811700003100830700002200861856013000883       2012                        eng d  a1523-706000aOrganocatalytic sequential alpha-amination/corey-chaykovsky reaction of aldehydes: a high yield synthesis of 4-hydroxypyrazolidine derivatives0 aOrganocatalytic sequential alphaaminationcoreychaykovsky reactio  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY  a2468-24710 v143 a<p>A tandem reaction of in situ generated a-amino aldehydes with dimethyloxosulfonium methylide under Corey-Chaykovsky reaction conditions proceeds efficiently to give 4-hydroxypyrazolidine derivatives in high yields with excellent enantio- and diastereoselectivities. This organocatalytic sequential method provides for the efficient synthesis of anti-1,2-aminoalcohols, structural subunits present in several bioactive molecules as well.</p>1 aKumar, Senthil1 aVenkataramasubramanian, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/organocatalytic-sequential-alpha-aminationcorey-chaykovsky-reaction-aldehydes-high-yield-001276nas a2200229   4500008004100000022001400041245007300055210006900128260010600197300001200303490000700315520046700322653001400789653002000803653001200823653001400835653001900849100003200868700001700900700002200917856010700939       2012                        eng d  a0040-403900aPd-catalyzed selective hydrosilylation of aryl ketones and aldehydes0 aPdcatalyzed selective hydrosilylation of aryl ketones and aldehy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a148-1500 v533 a<p>Pd salts in combination with triethylsilane as hydride source and DMF as solvent has been found to be excellent catalytic combination that selectively reduces aryl ketones and aldehydes under mild conditions to afford triethylsilyloxy compounds in excellent yields. Product selectivity to the respective benzyl alcohols can however be achieved when the reaction was performed in DMF/H2O (4:1) as solvent system. (C) 2011 Elsevier Ltd. All rights reserved.</p>10aaldehydes10aHydrosilylation10aKetones10aPalladium10aTriethylsilane1 aChouthaiwale, Pandurang, V.1 aRawat, Varun1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/pd-catalyzed-selective-hydrosilylation-aryl-ketones-and-aldehydes-001209nas a2200181   4500008004100000022001400041245013600055210006900191260007100260300001400331490000700345520045900352100002000811700002400831700002500855700002200880856012500902       2013                        eng d  a0022-326300aCuCN-Mediated cascade cyclization of 4-(2-bromophenyl)-2-butenoates: a high-yield synthesis of substituted naphthalene amino esters0 aCuCNMediated cascade cyclization of 42bromophenyl2butenoates a h  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY  a5045-50500 v783 a<p>A new method of CuCN-mediated one-pot cyclization of 4-(2-bromophenyl)-2-butenoates leading to efficient synthesis of substituted naphthalene amino esters including phenanthrene aromatic structural units is described. Deuterium labeling studies establish that this one-pot cascade cyclization proceeds through isomerization of olefin, intramolecular C-C bond cyclization, and aromatization as the key intermediates, all occurring in a single step.</p>1 aReddy, Santhosh1 aPrasad, Pragati, K.1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cucn-mediated-cascade-cyclization-4-2-bromophenyl-2-butenoates-high-yield-synthesis-001071nas a2200169   4500008004100000022001400041245011300055210006900168260011000237300001400347490000600361520033200367100002600699700002300725700002200748856013100770       2013                        eng d  a2046-206900aN-Heterocyclic carbene catalyzed esterification of aromatic aldehydes with alcohols under aerobic conditions0 aNHeterocyclic carbene catalyzed esterification of aromatic aldeh  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcDEC  a1695-16980 v33 a<p>A simple, organocatalytic procedure for the direct oxidative esterification of a variety of aromatic aldehydes with alcohols has been described that affords the corresponding aromatic esters in high yields. The method employs N-heterocyclic carbenes as catalysts and molecular O-2 as an oxidant under ambient conditions.</p>1 aKiran, I., N. Chaitha1 aLalwani, Komal, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-esterification-aromatic-aldehydes-alcohols-under-aerobic-001502nas a2200229   4500008004100000022001400041245011900055210006900174260010600243300001400349490000700363520058100370653003000951653002700981653002701008653001101035653002501046100002301071700002401094700002201118856013201140       2013                        eng d  a0040-403900aN-Heterocyclic carbene catalyzed oxidative stannylation of aldehydes: a facile entry to organotin(IV) carboxylates0 aNHeterocyclic carbene catalyzed oxidative stannylation of aldehy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a2679-26810 v543 a<p>A simple protocol is described for the oxidative transformation of aldehydes to the corresponding organotin(IV) carboxylates in high yields (up to 90%) that utilizes atmospheric O-2 as the sole oxidant, N-heterocyclic carbene as catalyst (at 10 mol %), and tributyl tin chloride as stannylating agent. The uniqueness of the reaction lies in the direct conversion of aldehydes to the corresponding organotin(IV) carboxylates via stannylation of carboxylic acids, generated from the reaction of a Breslow intermediate with O-2. (c) 2013 Elsevier Ltd. All rights reserved.</p>10aCarboxylic acid stannanes10aN-Heterocyclic carbene10aOxidative stannylation10aoxygen10aTributyltin chloride1 aReddi, Rambabu, N.1 aMalekar, Pushpa, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-oxidative-stannylation-aldehydes-facile-entry-organotiniv-001149nas a2200169   4500008004100000022001400041245016500055210006900220260011000289300001400399490000700413520036600420100002300786700002400809700002200833856012400855       2013                        eng d  a1477-052000aN-Heterocyclic carbene catalyzed regioselective oxo-acyloxylation of alkenes with aromatic aldehydes: a high yield synthesis of alpha-acyloxy ketones and esters0 aNHeterocyclic carbene catalyzed regioselective oxoacyloxylation   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a6477-64820 v113 a<p>An N-heterocyclic carbene (NHC)-catalyzed reaction of alkenes with aromatic aldehydes providing for a high yield synthesis of alpha-acyloxy ketones and esters has been described. This unprecedented regioselective oxidative process employs NBS and Et3N in stoichiometric amounts and O-2 (1 atm) as an oxidant under ambient conditions in DMSO as a solvent.</p>1 aReddi, Rambabu, N.1 aMalekar, Pushpa, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-regioselective-oxo-acyloxylation-alkenes-aromatic-001256nas a2200169   4500008004100000022001400041245018300055210006900238260011000307300001400417490000700431520043900438100003000877700002600907700002200933856013100955       2013                        eng d  a1477-052000aOptically pure gamma-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: a formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide0 aOptically pure gammabutyrolactones and epoxy esters via two ster  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a1280-12850 v113 a<p>The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(III)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted gamma-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.</p>1 aDevalankar, Dattatray, A.1 aKarabal, Pratibha, U.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/optically-pure-gamma-butyrolactones-and-epoxy-esters-two-stereocentered-hkr-3-substituted-001338nas a2200169   4500008004100000022001400041245019000055210006900245260011000314300001400424490000700438520053800445100001700983700001901000700002201019856012701041       2013                        eng d  a1477-052000aProline catalyzed sequential alpha-aminooxylation or -amination/reductive cyclization of o-nitrohydrocinnamaldehydes: a high yield synthesis of chiral 3-substituted tetrahydroquinolines0 aProline catalyzed sequential alphaaminooxylation or aminationred  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a3608-36110 v113 a<p>A new sequential organocatalytic method for the synthesis of chiral 3-substituted (X = OH, NH2) tetrahydroquinoline derivatives (THQs) [ee up to 99%, yield up to 87%] based on alpha-aminooxylation or -amination followed by reductive cyclization of o-nitrohydrocinnamaldehydes has been described. This methodology has been efficiently demonstrated in the synthesis of two important bioactive molecules namely (-)-sumanirole (96% ee) and 1-[(S)-3-(dimethylamino)-3,4-dihydro-6,7-dimethoxy-quinolin-1(2H)-yl]- propanone (92% ee).</p>1 aRawat, Varun1 aKumar, Senthil1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/proline-catalyzed-sequential-alpha-aminooxylation-or-aminationreductive-cyclization-o-001237nas a2200169   4500008004100000022001400041245018500055210006900240260011000309300001400419490000700433520042500440100002600865700002500891700002200916856012900938       2014                        eng d  a1477-052000aCo(III)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: its application in the synthesis of ICI-118,551, an anti-hypertensive agent0 aCoIIIsalencatalyzed phenolic kinetic resolution of two stereocen  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a2349-23550 v123 a<p>The salen Co(III)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti-or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols in excellent yields and ees. The synthetic potential of this protocol is illustrated with an enantioselective synthesis of ICI-118,551, a beta-blocker, in a highly optically pure form (99% ee).</p>1 aKarabal, Pratibha, U.1 aKamble, Dayanand, A.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/coiiisalen-catalyzed-phenolic-kinetic-resolution-two-stereocentered-benzyloxy-and-azido-001366nas a2200241   4500008004100000022001400041245019800055210006900253260007500322300001200397490000700409520039700416653001100813653001700824653001300841653001600854653003000870653002100900100003000921700003200951700002200983856011901005       2014                        eng d  a0936-521400aConcise enantioselective syntheses of (+)-L-733,060 and (2S,3S)-3-hydroxypipecolicw acid by cobalt(III)(salen)-catalyzed two-stereocenter hydrolytic kinetic resolution of racemic azido epoxides0 aConcise enantioselective syntheses of L733060 and 2S3S3hydroxypi  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJAN  a102-1040 v253 a<p>An efficient synthesis of the 2,3-disubstituted piperidines (+)-L-733,060 and (2S,3S)-3-hydroxypipecolic acid (99% ee) in high optical purity from commercially available starting materials is described. The strategy involves a cobalt-catalyzed hydrolytic kinetic resolution of a racemic azido epoxide with two stereocenters and an intramolecular reductive cyclization as key reactions.</p>10aazides10acyclizations10aepoxides10apiperidines10astereoselective synthesis10aWittig reactions1 aDevalankar, Dattatray, A.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-syntheses-l-733060-and-2s3s-3-hydroxypipecolicw-acid-001344nas a2200217   4500008004100000022001400041245018400055210006900239260007700308300001400385490000800399520045600407653001500863653002400878653002200902653001200924653001300936100002400949700002200973856013100995       2014                        eng d  a1615-415000aCopper(I) bromide-catalyzed carbonylative coupling of aryl halides with phenols, alcohols and amines using sodium cyanide as C-1 source: a synthesis of carboxylic acid derivatives0 aCopperI bromidecatalyzed carbonylative coupling of aryl halides   aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJUL  a2231-22380 v3563 a<p>A new ``carbon monoxide-free'' synthesis of carboxylate derivatives via carbonylative coupling of aryl bromides with phenols, alcohols, amines and acids in the presence of copper(I) bromide as catalyst and sodium cyanide in a stoichiometric amount has been developed. Its intramolecular version provides for the preparation of lactones (e.g., isochroman-1-ones and isobenzfuranones), imides, anhydrides and lactams in excellent yields (73-96%).</p>10aanhydrides10aC-1 building blocks10aisochroman-1-ones10alactams10alactones1 aPrasad, Pragati, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/copperi-bromide-catalyzed-carbonylative-coupling-aryl-halides-phenols-alcohols-and-amines-001266nas a2200169   4500008004100000022001400041245016200055210006900217260007100286300001400357490000700371520051800378100002300896700002400919700002200943856013100965       2014                        eng d  a1523-706000aI-2-catalyzed regioselective Oxo- and hydroxy-acyloxylation of alkenes and enol ethers: a facile access to alpha-acyloxyketones, esters, and diol derivatives0 aI2catalyzed regioselective Oxo and hydroxyacyloxylation of alken  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a5674-56770 v163 a<p>I-2-catalyzed oxo-acyloxylation of alkenes and enol ethers with carboxylic acids providing for the high yield synthesis of a-acyloxyketones and esters is described. This unprecedented regioselective oxidative process employs TBHP and Et3N in stoichiometric amounts under metal-free conditions in DMSO as solvent. Additionally, I-2-catalysis allows the direct hydroxy-acyloxylation of alkenes with the sequential addition of BH3 center dot SMe2 leading to monoprotected diol derivatives in excellent yields.</p>1 aReddi, Rambabu, N.1 aPrasad, Pragati, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/i-2-catalyzed-regioselective-oxo-and-hydroxy-acyloxylation-alkenes-and-enol-ethers-facile-001204nas a2200229   4500008004100000022001400041245008100055210006900136260007500205300001100280490000700291520042000298653001900718653002200737653001600759653001300775653001400788100002300802700001900825700002200844856010800866       2014                        eng d  a0936-521400aOne-pot synthesis of cyclic carbonates from aldehydes, sulfur ylide, and CO20 aOnepot synthesis of cyclic carbonates from aldehydes sulfur ylid  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJAN  a97-1010 v253 a<p>Treatment of aldehydes with sulfur ylide (CH2=SOMe2 or CH2=SMe2), in the presence of CO2 (1 atm) bubbled sequentially under mild conditions, produces cyclic carbonates in preparative yields. Sodium iodide formed in situ promotes the reaction between epoxide as intermediate and CO2 at ambient conditions, thus constituting a powerful metal-free synthesis of organic cyclic carbonates directly from aldehydes.</p>10aCarbon dioxide10acyclic carbonates10acyclization10aepoxides10aInsertion1 aAher, Ravindra, D.1 aKumar, Senthil1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/one-pot-synthesis-cyclic-carbonates-aldehydes-sulfur-ylide-and-co2-001251nas a2200157   4500008004100000022001400041245015000055210006900205260011000274300001600384490000600400520052800406100002300934700002200957856011400979       2014                        eng d  a2046-206900aSimple and efficient synthesis of isocoumarins and alkylidenephthalides from 3-(1-hydroxycarbethoxy/alkyl)phthalides with a DEAD/PPh3/TBHP system0 aSimple and efficient synthesis of isocoumarins and alkylidenepht  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a57658-576610 v43 a<p>A facile and novel approach to the synthesis of 3-carbethoxy-isocoumarins and 3-alkylidenephthalides is described. The methodology employs DEAD/PPh3/TBHP as the reagent system proceeding through unprecedented 1,2-shift intramolecular ring expansion or simple elimination depending upon substituents present on 3-substituted phthalides, with broader substrate scope. This strategy is amply demonstrated in the short synthesis of bioactive molecules such as cytogenin and (Z)-3-butylidene-7-hydroxy-5-methoxyphthalide.</p>1 aGadakh, Sunita, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/simple-and-efficient-synthesis-isocoumarins-and-alkylidenephthalides-3-1-001325nas a2200157   4500008004100000022001400041245017100055210006900226260010600295300001200401490000700413520057700420100002300997700002201020856012501042       2015                        eng d  a0957-416600aCo-catalyzed two-stereocentered hydrolytic kinetic resolution: application to the synthesis of yashabushidiols A and B and the lactone unit of compactin and mevinolin0 aCocatalyzed twostereocentered hydrolytic kinetic resolution appl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a118-1230 v263 a<p>A short and efficient enantioselective synthesis of yashabushidiols A and B and the beta-hydroxy-delta-lactone moiety of compactin and mevinolin with high enantiomeric purity (98% ee) is described starting from commercially available materials. The strategy mainly comprises of iodine-induced intramolecular electrophilic addition of a carbonate occurring in a highly diastereoselective fashion and the Co-catalyzed two-stereocentered hydrolytic kinetic resolution of a functionalized epoxide as the chiral inducing step. (C) 2014 Elsevier Ltd. All rights reserved.</p>1 aGadakh, Sunita, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/co-catalyzed-two-stereocentered-hydrolytic-kinetic-resolution-application-synthesis-001128nas a2200157   4500008004100000022001400041245018900055210006900244260000900313300001000322490000700332520045700339100002500796700002200821856012700843       2015                        eng d  a0957-416600aConcise enantioselective synthesis of (2S,3S)-3-hydroxypipecolic acid via proline catalyzed alpha-aminooxylation of aldehydes and Pd-catalyzed ether directed aza-Claisen rearrangements0 aConcise enantioselective synthesis of 2S3S3hydroxypipecolic acid  cJAN   a24-280 v263 a<p>An efficient approach to (2S,3S)-3-hydroxypipecolic acid with an overall yield of 10.2% and 98% ee starting from 1,5-pentanediol has been developed. The key steps employed in the synthesis are the D-proline catalyzed sequential alpha-aminooxylation/Horner-Wadsworth-Emmons olefination of an aldehyde and the Pd-catalyzed MOM-ether directed aza-Claisen rearrangement of an allylic trichloroacetimidate. (C) 2014 Elsevier Ltd. All rights reserved.</p>1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-2s3s-3-hydroxypipecolic-acid-proline-catalyzed-alpha01158nas a2200157   4500008004100000022001400041245009300055210006900148260010600217300001200323490000700335520049700342100001600839700002200855856012300877       2015                        eng d  a0957-416600aConcise enantioselective synthesis of marine macrolide-stagonolide E via organocatalysis0 aConcise enantioselective synthesis of marine macrolidestagonolid  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR  a344-3490 v263 a<p>A short and efficient enantioselective synthesis of marine macrolide stagonolide E in high enantiomeric purity (98% ee and 8.5% overall yield) starting from commercially available raw materials has been achieved. The strategy involves proline catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination, highly stereoselective Ando's cis-olefination, and modified Yamaguchi macrolactonization as the key reaction steps. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aDey, Soumen1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-marine-macrolide-stagonolide-e-organocatalysis-001284nas a2200229   4500008004100000022001400041245008300055210006900138260008600207300001400293490000700307520045600314653002500770653001600795653002300811653002100834653002000855100001600875700002600891700002200917856011500939       2015                        eng d  a0039-791100aConcise enantioselective synthesis of naturally active (S)-3-hydroxypiperidine0 aConcise enantioselective synthesis of naturally active S3hydroxy  a530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcAPR  a1559-15650 v453 a<p>A short and efficient enantioselective synthesis of natural product (S)-3-hydroxypiperidine has been achieved starting from commercially available raw materials employing two catalytic routes: (i) cocatalyzed hydrolytic kinetic resolution (HKR) of racemic methyl-3-(oxiran-2-yl)propanoate; (ii) proline-catalyzed -aminooxylation followed by Horner-Wardsworth-Emmons olefination in high enantiomeric purity (97% ee) and high overall yield (38%).</p>10aAsymmetric synthesis10abioactivity10aEnantioselectivity10aNatural products10aorganocatalysis1 aDey, Soumen1 aKarabal, Pratibha, U.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-naturally-active-s-3-hydroxypiperidine-001118nas a2200157   4500008004100000022001400041245016900055210006900224260000800293300001000301490000700311520047600318100001600794700002200810856012800832       2015                        eng d  a0957-416600aConcise enantioselective synthesis of (R)-selegiline, (S)-benzphetamine and formal synthesis of (R)-sitagliptin via electrophilic azidation of chiral imide enolates0 aConcise enantioselective synthesis of Rselegiline Sbenzphetamine  cJAN  a67-720 v263 a<p>A concise and high yielding enantioselective synthesis of (R)-selegiline, an anti-Parkinson's drug, (S)-benzphetamine, an anti-obesity agent, and (S)-sitagliptin, an anti-diabetic drug has been described starting from commercially available starting materials employing Evans' electrophilic azidation of chiral imide enolates as a key chiral inducing step, which proceeds in a highly diastereoselective manner (&gt;99%). (C) 2014 Elsevier Ltd. All rights reserved.</p>1 aDey, Soumen1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-r-selegiline-s-benzphetamine-and-formal-synthesis-r-001094nas a2200205   4500008004100000022001400041245008500055210006900140260008600209300001400295490000700309520034800316653002500664653001600689653001800705653001100723100003100734700002200765856010100787       2015                        eng d  a0039-791100aConcise synthesis of (+/-)-clopidogrel via carboxylation of benzylamine with CO20 aConcise synthesis of clopidogrel via carboxylation of benzylamin  a530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcJUN  a2099-21050 v453 a<p>A concise and efficient synthesis of (+/-)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.</p>10aAntithrombatic agent10aclopidogrel10aCO2 insertion10aPlavix1 aVenkataramasubramanian, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-synthesis-clopidogrel-carboxylation-benzylamine-co2-001189nas a2200157   4500008004100000022001400041245011500055210006900170260011000239300001400349490000700363520049300370100002500863700002200888856012100910       2015                        eng d  a1477-052000aCu-catalyzed debrominative cyanation of gem-dibromoolefins: a facile access to alpha,beta-unsaturated nitriles0 aCucatalyzed debrominative cyanation of gemdibromoolefins a facil  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a5918-59230 v133 a<p>An efficient catalytic route for the synthesis of alpha,beta-unsaturated nitriles from easily accessible gem-dibromoolefins has been developed. The method utilized inexpensive reagents such as Cu2O as a catalyst, L-proline as a ligand and NaCN as a cyanide source to afford alpha,beta-unsaturated nitriles in high yields (62-86%). A deuterium exchange study has shown that one of the bromide atoms of gem-dibromoolefins exchanges with cyanide while the other with a deuterium atom.</p>1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cu-catalyzed-debrominative-cyanation-gem-dibromoolefins-facile-access-alphabeta-001473nas a2200169   4500008004100000022001400041245022700055210006900282260010600351300001200457490000700469520062300476100003101099700001901130700002201149856013201171       2015                        eng d  a0957-416600aEnantioselective synthesis of guggultetrol and D-ribo-phytosphingosine tetraacetate via L-proline catalyzed sequential alpha-aminooxylation/Horner-Wardsworth-Emmons olefination-Sharpless asymmetric dihydroxylation strategy0 aEnantioselective synthesis of guggultetrol and Dribophytosphingo  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a571-5760 v263 a<p>An efficient enantioselective synthesis of two bioactive molecules, that is, guggultetrol and D-ribo-phytosphingosine, is described with high enantioselectivity (&gt;98% ee) starting from commercially available 1-hexadecanol. The synthesis comprises organocatalyzed sequential alpha-aminooxylation of an aldehyde followed by Horner-Wardsworth-Emmons olefination and Sharp less asymmetric dihydroxylation as the key chiral inducing steps. For both syntheses, gamma-hydroxy-alpha,beta-unsaturated ester serves as the common intermediate obtained from proline catalysis. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aVenkataramasubramanian, V.1 aKumar, Senthil1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/enantioselective-synthesis-guggultetrol-and-d-ribo-phytosphingosine-tetraacetate-l-proline-001284nas a2200157   4500008004100000022001400041245018200055210006900237260010600306300001200412490000700424520052400431100002500955700002200980856012401002       2015                        eng d  a0957-416600aFirst enantioselective synthesis of (2S,3S)-3-hydroxy-L-arginine via proline catalyzed alpha-aminooxylation of aldehyde and Pd-catalyzed ether-directed aza-Claisen rearrangement0 aFirst enantioselective synthesis of 2S3S3hydroxyLarginine via pr  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a548-5520 v263 a<p>A concise enantioselective synthesis of (2S,3S)-3-hydroxy-L-arginine with an overall yield of 10.9% and 98% ee, starting from commercially available 1,4-butanediol in ten linear steps has been achieved. The key chiral inducing steps are D-proline catalyzed sequential alpha-aminooxylation/Horner-Wadsworth-Emmons olefination of an aldehyde and the subsequent diastereoselective MOM-ether-directed Pd-catalyzed aza-Claisen rearrangement of allylic trichloroacetimidate. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/first-enantioselective-synthesis-2s3s-3-hydroxy-l-arginine-proline-catalyzed-alpha-001496nas a2200217   4500008004100000022001400041245015000055210006900205260007500274300001400349490000700363520062000370653002400990653002301014653002301037653002101060653002001081100002301101700002201124856013201146       2015                        eng d  a1434-193X00aFirst enantioselective synthesis of surinamensinol B and a non-natural polysphorin analogue by a two-stereocentered hydrolytic kinetic resolution0 aFirst enantioselective synthesis of surinamensinol B and a nonna  aPOSTFACH 101161, 69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcNOV  a7344-73510 v333 a<p>An efficient and economical approach to the synthesis of antitumor and anti-inflammatory surinamensinol B (1) and antimalarial polysphorin analogue 2 has been achieved with high enantiomeric purity (96% ee) by starting from commercially available 3,4,5-trimethoxybenzaldehyde. The key steps of the strategy include a Co-catalyzed two-stereocentered hydrolytic kinetic resolution (HKR) of racemic 2[( methoxymethoxy)(3,4,5-trimethoxyphenyl)methyl] oxirane (13) as the chiral inducing step followed by a Mitsunobu reaction. Chiral epoxide 14 and chiral diol 15 were utilized in the syntheses of both compounds.</p>10aBiological activity10aEnantioselectivity10aKinetic resolution10aNatural products10aTotal synthesis1 aLalwani, Komal, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/first-enantioselective-synthesis-surinamensinol-b-and-non-natural-polysphorin-analogue-two-102095nas a2200217   4500008004100000022001400041245017100055210006900226260011000295300001400405490000700419520116900426100002501595700002001620700002001640700002301660700002201683700002101705700002601726856012501752       2015                        eng d  a1463-926200aHighly efficient regioselective synthesis of pyrroles via a tandem enamine formation-Michael addition-cyclization sequence under catalyst- and solvent-free conditions0 aHighly efficient regioselective synthesis of pyrroles via a tand  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a3415-34230 v173 a<p>A convenient catalyst-free, three-component procedure was developed for the synthesis of tetrasubstituted pyrroles under solvent-free conditions and in green solvents glycerol, PEG-200 and water. A sequential enamine-formation, Michael addition and intramolecular cyclization of primary amines, 1,3-dicarbonyl compounds and isatin-derived Michael acceptors afforded 3-(1H-pyrrol-3-yl)indolin-2-ones in excellent yields. In this simple one-pot transformation the requirement of column chromatography purification of the products was completely avoided. Besides, the method is highly environmentally benign and atom-economical, and the only side product of this reaction was two molecules of water. A comparative study for the four developed conditions showed that the solvent-free conditions were superior regardless of the nature of the starting materials, and the green solvents were effective for alkyl and benzylamines affording higher yields compared to arylamines. The preliminary in vitro cytotoxic studies of a representative compound against Ehrlich's ascites carcinoma (EAC) tumor cells showed significant activity with a CTC50 value of 15.64 mu M.</p>1 aVivekanand, Thavaraj1 aVinoth, Perumal1 aAgieshkumar, B.1 aSampath, Natarajan1 aSudalai, Arumugam1 aMenendez, Carlos1 aSridharan, Vellaisamy  uhttps://library.ncl.res.in/content/highly-efficient-regioselective-synthesis-pyrroles-tandem-enamine-formation-michael-001204nas a2200229   4500008004100000022001400041245015100055210006900206260007500275300001600350490000700366520031300373653001400686653001600700653002800716653001400744653002200758100002300780700002400803700002200827856012500849       2015                        eng d  a1433-785100aN-Heterocyclic carbene catalyzed oxidative coupling of alkenes/alpha-bromoacetophenones with aldehydes: a facile entry to alpha,beta-epoxy ketones0 aNHeterocyclic carbene catalyzed oxidative coupling of alkenesalp  aPOSTFACH 101161, 69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcNOV  a14150-141530 v543 a<p>{A novel, N-heterocyclic carbene (NHC) catalyzed direct oxidative coupling of styrenes with aldehydes has been described for the synthesis of alpha,beta-epoxy ketones in good yields. This unprecedented regioselective oxidative coupling employs NBS/DBU/DMSO (DBU = 1,8-diazabicyclo [5.4. 0] undec-7-ene</p>10aaldehydes10aepoxidation10aN-heterocyclic carbenes10aOxidation10asynthetic methods1 aReddi, Rambabu, N.1 aPrasad, Pragati, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-oxidative-coupling-alkenesalpha-bromoacetophenones-101267nas a2200157   4500008004100000022001400041245018300055210006900238260011000307300001600417490000600433520049200439100002500931700002200956856013100978       2015                        eng d  a2046-206900aOne-pot highly enantio- and diastereoselective synthesis of anti,anti vinylic 3-amino-1,2 diols via proline catalyzed sequential alpha-amination/benzoyloxyallylation of aldehydes0 aOnepot highly enantio and diastereoselective synthesis of antian  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a21803-218050 v53 a<p>The first direct asymmetric synthesis of anti, anti vinylic 3-amino-1,2-diols from aldehydes is described via a one-pot sequential L-proline catalyzed alpha-amination/benzoyloxyallylation protocol. The reaction proceeds with exceptionally high diastereoselectivity (&gt;99%) as can be explained based on the Felkin-Ahn transition state model. Its effectiveness is proven unambiguously by demonstrating a short asymmetric synthesis of D-ribo-phytosphingosine tetraacetate (93% ee).</p>1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/one-pot-highly-enantio-and-diastereoselective-synthesis-antianti-vinylic-3-amino-12-diols-001189nas a2200169   4500008004100000022001400041245011600055210006900171260011000240300001600350490000600366520045300372100002300825700002300848700002200871856012600893       2015                        eng d  a2046-206900aOrganocatalytic [4+1]-annulation approach for the synthesis of densely functionalized pyrazolidine carboxylates0 aOrganocatalytic 41annulation approach for the synthesis of dense  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL  a65554-655590 v53 a<p>A novel one-pot [4+1]-annulation process for the asymmetric synthesis of densely functionalized pyrazolidine carboxylates is described. The in situ generated gamma-hydrazino-alpha,beta-unsaturated ester obtained via proline catalysis acts as a four-atom component, and Corey's sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrazolidine carboxylate units in a highly enantio- and diastereoselective fashion.</p>1 aLalwani, Komal, G.1 aAher, Ravindra, D.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/organocatalytic-41-annulation-approach-synthesis-densely-functionalized-pyrazolidine-001325nas a2200241   4500008004100000022001400041245014500055210006900200260007500269300001200344490000700356520038400363653002000747653002500767653001400792653002500806653002300831653002000854100003100874700002600905700002200931856013000953       2015                        eng d  a0936-521400aProline-catalyzed alpha-aminooxylation of beta-amino aldehydes: access to enantiomerically pure syn- and anti-3-amino-3-aryl-1,2-alkanediols0 aProlinecatalyzed alphaaminooxylation of betaamino aldehydes acce  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcFEB  a355-3580 v263 a<p>A new synthetic method for enantioselective synthesis of syn 3-amino-3-aryl-1,2-alkanediols via praline catalyzed alpha-aminaoxn y ylation of beta-amino aldehydes des are described. This methodology is successfully applied to a concise and protecting group-free asymmetric synthesis of (-)-cytoxazone (+)-epi-cytoxazone and formal synthesis of N-thiolated 2-oxazolidinone.</p>10aamino aldehydes10aAsymmetric synthesis10acatalysis10adiastereoselectivity10aEnantioselectivity10aNatural product1 aVenkataramasubramanian, V.1 aKiran, I., N. Chaitha1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/proline-catalyzed-alpha-aminooxylation-beta-amino-aldehydes-access-enantiomerically-pure-001132nas a2200169   4500008004100000022001400041245012800055210006900183260007100252300001400323490000700337520042300344100002300767700001900790700002200809856013100831       2015                        eng d  a0022-326300aProline-catalyzed sequential syn-mannich and [4+1]-annulation cascade reactions to form densely functionalized pyrrolidines0 aProlinecatalyzed sequential synmannich and 41annulation cascade   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a2024-20310 v803 a<p>A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Coreys sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.</p>1 aAher, Ravindra, D.1 aKumar, Senthil1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/proline-catalyzed-sequential-syn-mannich-and-41-annulation-cascade-reactions-form-densely-101447nas a2200217   4500008004100000022001400041245018700055210006900242260010600311300001400417490000700431520050600438653001600944653002700960653003400987653001901021653002401040100002301064700002201087856012001109       2015                        eng d  a0040-403900aShort enantioselective synthesis of ephedrine, amphetamine and their analogues via two stereocentered Co(III)-catalyzed hydrolytic kinetic resolution of racemic syn-benzyloxy epoxide0 aShort enantioselective synthesis of ephedrine amphetamine and th  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6488-64900 v563 a<p>An efficient route for the synthesis of 6 drugs belonging to phenethylamine and amphetamine classes in excellent overall yields and high optical purity has been described. The strategy involves introduction of stereogenic centers by means of two-stereocentered Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of racemic syn-benzyloxy epoxide followed by Pd-catalyzed regioselective cationic hydrogenation of amino alcohols as the key reactions. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aAmphetamine10aCationic hydrogenation10aHydrolytic kinetic resolution10aPhenethylamine10aStereogenic centers1 aLalwani, Komal, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-ephedrine-amphetamine-and-their-analogues-two-001564nas a2200169   4500008004100000022001400041245007700055210006900132260011000201300001400311490000700325520088700332100002201219700002301241700001901264856011101283       2015                        eng d  a1477-052000aSodium periodate mediated oxidative transformations in organic synthesis0 aSodium periodate mediated oxidative transformations in organic s  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a4374-43940 v133 a<p>The investigation of new oxidative transformations for the synthesis of carbon-heteroatom and heteroatom-heteroatom bonds is of fundamental importance in the synthesis of numerous bioactive molecules and fine chemicals. In this context, NaIO4, an exciting reagent, has attracted increasing attention enabling the development of these unprecedented oxidative transformations that are difficult to achieve otherwise. Thus, NaIO4 has been successfully explored as a versatile oxidant for a variety of fundamental organic transformations such as C-H activation, oxidative functionalization of alkenes and other interesting oxidative transformations and its application in the synthesis of bioactive natural products. This review summarizes recent developments in this area with NaIO4 as a versatile oxidant and brings out many challenges that still remain elusive for the future.</p>1 aSudalai, Arumugam1 aKhenkin, Alexander1 aNeumann, Ronny  uhttps://library.ncl.res.in/content/sodium-periodate-mediated-oxidative-transformations-organic-synthesis-001153nas a2200217   4500008004100000022001400041245010400055210006900159260007500228300001400303490000700317520036300324653001800687653001000705653002100715653001600736653001500752100002300767700002200790856012300812       2016                        eng d  a0936-521400aConcise enantioselective synthesis of (+)-L-733,060 and (+)-T-2328 via sequential proline catalysis0 aConcise enantioselective synthesis of L733060 and T2328 via sequ  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJUN  a1339-13430 v273 a<p>A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-2328 in high optical purity (93% ee) is described starting from phenyl N-Boc imine. The strategy involves proline-catalyzed Mannich reaction of an arylimine with acetaldehyde followed by -aminoxylation/Wittig olefination in a sequential fashion as the key steps.</p>10aAminoxylation10aimine10aMannich reaction10aolefination10asequential1 aLalwani, Komal, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-l-733060-and-t-2328-sequential-proline-catalysis01322nas a2200241   4500008004100000022001400041245009800055210006900153260010600222300001400328490000700342520041700349653001600766653002100782653002200803653001500825653001600840100002600856700003100882700002300913700002200936856012200958       2016                        eng d  a0040-403900aConcise enantioselective synthesis of (+)-sertraline and (-)-CP-52002 using proline catalysis0 aConcise enantioselective synthesis of sertraline and CP52002 usi  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a1053-10550 v573 a<p>A short enantioselective synthesis of (+)-sertraline and its C-4 epimer (-)-CP-52002 with an overall yield of 30%, respectively, as its hydrochloride has been described. The key steps are the proline catalyzed Mannich reaction of acetaldehyde and acid catalyzed intramolecular Friedel-Crafts' alkylation reaction of olefin proceeding with high optical purities. (C) 2016 Elsevier Ltd. All rights reserved.</p>10aIndatraline10aMannich reaction10aProline catalysis10aSertraline10aTametraline1 aKalshetti, Rupali, G.1 aVenkataramasubramanian, V.1 aKamble, Sanjay, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-sertraline-and-cp-52002-using-proline-catalysis01437nas a2200229   4500008004100000022001400041245017700055210006900232260007500301300001400376490000700390520052700397653001400924653002300938653002000961653001200981653001800993100002501011700002601036700002201062856012301084       2016                        eng d  a0936-521400aFormal enantioselective synthesis of (-)-epiquinamide by proline-catalyzed one-pot sequential -amination/propargylation of aldehyde and asymmetric dihydroxylation of olefin0 aFormal enantioselective synthesis of epiquinamide by prolinecata  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJUL  a1699-17020 v273 a<p>Two independent routes to the formal synthesis of (-)-epiquinamide, have been described: the first route utilizes an l-proline-catalyzed one-pot sequential -amination/propargylation of aldehyde, while the second one employs asymmetric dihydroxylation as the key reaction to install the stereochemistry. While the first synthesis was accomplished in nine steps with 24.4% overall yield and dr 9:1, the second strategy resulted in the synthesis in eight steps with 36.4% overall yield and with perfect enantiocontrol.</p>10aAmination10adiastereoselective10aDihydroxylation10aProline10aquinolizidine1 aAhuja, Brij, Bhushan1 aEmmanuvel, Lourdusamy1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/formal-enantioselective-synthesis-epiquinamide-proline-catalyzed-one-pot-sequential01324nas a2200217   4500008004100000022001400041245009000055210006900145260010600214300001000320490000700330520048900337653002100826653003100847653003400878653001400912653001500926100002300941700002200964856012000986       2016                        eng d  a0040-403900aFormal total synthesis of anti-helicobacter pylori agent (+)-spirolaxine methyl ether0 aFormal total synthesis of antihelicobacter pylori agent spirolax  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a25-280 v573 a<p>A convergent, formal enantioselective synthesis of anti-Helicobacter pylori agent, (+)-spirolaxine methyl ether 2 has been achieved in high enantiomeric purity starting from commercially available 1,5-pentanediol. The strategy mainly comprises of the Noyori's asymmetric reduction and Brown allylation/Cu-catalyzed lactonization as the key step for the construction of key chiral intermediates, spiroketal 3 and phthalide fragment 4. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aBrown allylation10aCu-catalyzed lactonization10aNoyori's asymmetric reduction10aPhthalide10aSpiroketal1 aGadakh, Sunita, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/formal-total-synthesis-anti-helicobacter-pylori-agent-spirolaxine-methyl-ether-001046nas a2200193   4500008004100000022001400041245005700055210005400112260011000166300001400276490000700290520034600297100002400643700002600667700002300693700002300716700002200739856009100761       2016                        eng d  a1477-052000aI-2-mediated regioselective C-3 azidation of indoles0 aI2mediated regioselective C3 azidation of indoles  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a3027-30300 v143 a<p>An unprecedented synthesis of novel 3-azido indoles has been developed using I-2 and NaN3 in high yields and excellent regio-selectivity. The reaction proceeds under metal-free conditions at room temperature. Essentially, an umpolung in reactivity at the C-3 position of indole has been achieved by the activation of indoles with I-2.</p>1 aPrasad, Pragati, K.1 aKalshetti, Rupali, G.1 aReddi, Rambabu, N.1 aKamble, Sanjay, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/i-2-mediated-regioselective-c-3-azidation-indoles-001257nas a2200241   4500008004100000022001400041245015100055210006900206260007500275300001000350490000600360520034400366653001400710653001300724653002100737653002800758653001100786100002300797700001900820700002400839700002200863856013000885       2016                        eng d  a2193-580700aN-heterocyclic-carbene-catalyzed regioselective oxidative ring-opening of epoxides with aromatic aldehydes: a facile entry to alpha-acyloxyketones0 aNheterocycliccarbenecatalyzed regioselective oxidative ringopeni  aPOSTFACH 101161, 69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJAN  a48-510 v53 a<p>A high-yielding synthesis of -acyloxyketones using a N-heterocyclic-carbene (NHC)-catalyzed, oxidative ring-opening of epoxides with aromatic aldehydes is described. This regioselective, oxidative process utilizes a N-bromosuccinimide (NBS)/DMSO combination as the oxidant system and Et3N as the base under mild reaction conditions.</p>10aaldehydes10aepoxides10ahalogen oxidants10aN-heterocyclic carbenes10aoxygen1 aReddi, Rambabu, N.1 aGontala, Arjun1 aPrasad, Pragati, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-regioselective-oxidative-ring-opening-epoxides-aromatic-001195nas a2200217   4500008004100000022001400041245009700055210006900152260010600221300001400327490000700341520037500348653002000723653001800743653001300761653002000774653001200794100002300806700002200829856012600851       2016                        eng d  a0040-403900aOrganocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-120 aOrganocatalytic route to enantioselective synthesis of ceramide   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a2445-24470 v573 a<p>A new organocatalytic approach to the synthesis of ceramide trafficking inhibitor HPA-12 has been described starting from phenacyl bromide. The strategy involves chiral CBS reduction of gamma-ketoester and proline-catalyzed alpha-amination reaction of aldehyde followed by reduction as the key chirality inducing steps. (C) 2016 Elsevier Ltd. All rights reserved.</p>10aalpha-Amination10aCBS reduction10aCeramide10aOrganocatalytic10aProline1 aLalwani, Komal, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/organocatalytic-route-enantioselective-synthesis-ceramide-trafficking-inhibitor-hpa-1201527nas a2200205   4500008004100000022001400041245015000055210006900205260007100274300001400345490000700359520070200366100002001068700002301088700001901111700002201130700001901152700002601171856012401197       2016                        eng d  a1523-706000aPalladium-catalyzed internal nucleophile-assisted hydration-olefin insertion cascade: diastereoselective synthesis of 2,3-dihydro-1H-inden-1-ones0 aPalladiumcatalyzed internal nucleophileassisted hydrationolefin   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL  a3442-34450 v183 a<p>A novel palladium-catalyzed hydration-olefin insertion cascade assisted by internal nucleophiles was developed for the synthesis of biologically significant 2,3-dihydro-1H-inden-1-ones under mild conditions. A detailed mechanistic study revealed that the assistance of the internal nucleophiles is crucial to trigger the cascade reaction via nucleopalladation of the alkyne moiety. The overall reaction is equivalent to regioselective hydration of alkynes followed by intramolecular Michael addition. This highly efficient and 100% atom-economical domino sequence afforded cis-2,3-disubstituted 2,3-dihydro-1H-inden-1-ones in excellent yields (up to 99%) with complete diastereoselectivity.</p>1 aVinoth, Perumal1 aNagarajan, Subbiah1 aMaheswari, Uma1 aSudalai, Arumugam1 aPace, Vittorio1 aSridharan, Vellaisamy  uhttps://library.ncl.res.in/content/palladium-catalyzed-internal-nucleophile-assisted-hydration-olefin-insertion-cascade01490nas a2200253   4500008004100000022001400041245017700055210006900232260010600301300001200407490000700419520047900426653001800905653002700923653001400950653000900964653002300973100001600996700002301012700002501035700002301060700002201083856013101105       2016                        eng d  a0040-403900aPd-catalyzed reductive cleavage of N-N bond in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates with PMHS: application to a formal enantioselective synthesis of (R)-sitagliptin0 aPdcatalyzed reductive cleavage of NN bond in dibenzyl1alkylhydra  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a684-6870 v573 a<p>An environmentally benign approach involving Pd-catalyzed reductive N-N bond cleavage in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates leading to the synthesis of N-(tert-butoxy)carbamates under very mild conditions has been described. PMHS serves as an inexpensive source of hydride in MeOH/deionized H2O medium. This protocol has been successfully applied in the formal synthesis of (R)-sitagliptin, an anti-diabetic drug. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aanti-Diabetic10aEnvironmentally benign10aHydrazine10aPMHS10aReductive cleavage1 aDey, Soumen1 aGadakh, Sunita, K.1 aAhuja, Brij, Bhushan1 aKamble, Sanjay, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/pd-catalyzed-reductive-cleavage-n-n-bond-dibenzyl-1-alkylhydrazine-12-dicarboxylates-pmhs-001064nas a2200145   4500008004100000245012400041210006900165260000800234300001400242490000700256520048400263100002300747700002200770856012600792       2016                        eng d00aProline catalyzed enantioselective synthesis of (2S,3S)-3-hydroxypipecolic acid and formal synthesis of (+)-swainsonine0 aProline catalyzed enantioselective synthesis of 2S3S3hydroxypipe  cMAY  a2021-20240 v573 aA short enantioselective synthesis of (2S,3S)-3-hydroxypipecolic acid (overall yield: 18.8%; 96% ee) and formal synthesis of (+)-swainsonine (overall yield: 13.6%; 96% ee) have been described starting from commercially available acrolein. The synthetic strategy involves a high enantioselective L-proline catalyzed sequential c-amination and diastereoselective (dr > 99:1) Barbier allylation of aldehyde in one-pot as the key reaction. (C) 2016 Elsevier Ltd. All rights reserved.1 aAher, Ravindra, D.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/proline-catalyzed-enantioselective-synthesis-2s3s-3-hydroxypipecolic-acid-and-formal-001363nas a2200169   4500008004100000022001400041245016900055210006900224260007100293300001200364490000700376520060900383100002400992700002301016700002201039856013201061       2016                        eng d  a1523-706000aRegioselective oxo-amination of alkenes and enol ethers with N-bromosuccinimide-dimethyl sulfoxide combination: a facile synthesis of alpha-amino-ketones and esters0 aRegioselective oxoamination of alkenes and enol ethers with Nbro  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a500-5030 v183 a<p>An unprecedented conversion of alkenes and enol ethers to the corresponding a-imido carbonyl compounds with excellent regioselectivity and yields has been developed. This oxo-amination process employs readily available N-bromosuccinimide (NBS) and secondary amines as N-sources and dimethyl sulfoxide (DMSO) as the oxidant and also leads to the production of amino alcohols in a single step on reduction, thus broadening the scope of this operationally simple reaction. For the first time, the formation of reactive Me2S+-O-Br species generated by the interaction of NBS with DMSO has been proven.</p>1 aPrasad, Pragati, K.1 aReddi, Rambabu, N.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/regioselective-oxo-amination-alkenes-and-enol-ethers-n-bromosuccinimide-dimethyl-sulfoxide-001245nas a2200169   4500008004100000245018100041210006900222260000800291300001200299490000700311520053800318100002300856700002400879700002600903700002200929856012400951       2017                        eng d00aConcise enantioselective synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol using Co(III)(salen)-catalyzed hydrolytic kinetic resolution of a two-stereocentered anti-azido epoxide0 aConcise enantioselective synthesis of 14dideoxy14iminoDarabinito  cJAN  a162-1650 v283 aA concise enantioselective synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol, (+)-DAB-1, has been described in good overall yield (18.1%) and with high enantiomeric purity (up to 98% ee) starting from a simple raw material, cis-2-butene-1,4-diol. The Co-catalyzed hydrolytic kinetic resolution of a two-stereocentered racemic azido epoxide followed by asymmetric dihydroxylation of the alkene and 'one pot' reductive cyclisation of the azido diol are key reactions in the synthetic sequence. (C) 2016 Elsevier Ltd. All rights reserved.1 aReddi, Rambabu, N.1 aPrasad, Pragati, K.1 aKalshetti, Rupali, G.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-14-dideoxy-14-imino-d-arabinitol-using-coiiisalen01044nas a2200169   4500008004100000022001400041245015900055210006900214260000800283300001400291490000700305520036100312100002300673700003000696700002200726856012600748       2017                        eng d  a0022-326300aDiastereoselective synthesis of chiral 2,3-disubstituted lndolines via formal [3+2]-cycloaddition of arynes with gamma-amino-alpha,beta-unsaturated esters0 aDiastereoselective synthesis of chiral 23disubstituted lndolines  cJUN  a5940-59460 v823 aA one step formal [3+2]-annulation protocol for the synthesis of 2,3-disubstituted indolines is described. The in situ generated aryne acts as a two-atom component, and gamma-amino-alpha,beta-unsaturated esters acting as a three-atom component to construct indoline units in a highly regio- and diastereoselective manner with yields ranging from 63 to 80%.1 aAher, Ravindra, D.1 aSuryavanshi, Gurunath, M.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/diastereoselective-synthesis-chiral-23-disubstituted-lndolines-formal-32-cycloaddition01198nas a2200217   4500008004100000022001400041245015200055210006900207260000900276300001400285490000700299520040000306653003300706653001900739653002100758653001400779100001900793700001900812700002200831856012700853       2018                        eng d  a0040-403900a"Metal-free'' synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives0 aMetalfree synthesis of 123triazoles via tandem azidation intramo  cJUN   a2365-23670 v593 a<p>An efficient ``one-pot'' method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives on treatment with NaN3 in DMF under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved.</p>10aIntramolecular cycloaddition10aRegioselective10aTandem azidation10atriazoles1 aKumar, Senthil1 aGadakh, Sunita1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/metal-free-synthesis-123-triazoles-tandem-azidation-intramolecular-32-cycloaddition-and00697nas a2200217   4500008004100000245007200041210006900113260000800182300001400190490001000204100002200214700001300236700001900249700001700268700001600285700001400301700002000315700002200335700001900357856010300376       2018                        eng d00aNi-Catalyzed dimerization and hydroperfluoroarylation of 1,3-dienes0 aNiCatalyzed dimerization and hydroperfluoroarylation of 13dienes  cAUG  a9267-92770 v 83  1 aIwasaki, Takanori1 aMin, Xin1 aFukuoka, Asuka1 aZhu, Longzhi1 aQiu, Renhua1 aYang, Tao1 aEhara, Masahiro1 aSudalai, Arumugam1 aKambe, Nobuaki  uhttps://library.ncl.res.in/content/ni-catalyzed-dimerization-and-hydroperfluoroarylation-13-dienes01252nas a2200229   4500008004100000022001400041245013400055210006900189260000800258300001400266490000700280520043900287653002400726653002500750653002300775653002100798653002000819100001600839700001900855700002200874856012600896       2019                        eng d  a0376-469900aConcise formal synthesis of (-)-(6R,11R,14R)-colletallol via D-proline catalysed alpha-aminooxylation-Wittig olefination strategy0 aConcise formal synthesis of 6R11R14Rcolletallol via Dproline cat  cSEP  a1029-10360 v583 a<p>An efficient enantioselective formal synthesis of marine macrolide (-)-(6R,11R,14R)-colletallol has been achieved starting from commercially available raw materials. The key reactions include the D-proline catalyzed a-aminooxylation of aldehyde followed by Horner-Wardsworth-Emmons olefination in a sequential fashion to give the macrolide key intermediate 5 in high enantiomeric purity (97% ee) and high overall yield (32%).</p>
10aalpha-aminoxylation10aAsymmetric synthesis10aEnantioselectivity10aNatural products10aorganocatalysis1 aDey, Soumen1 aGadakh, Sunita1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-formal-synthesis-6r11r14r-colletallol-d-proline-catalysed-alpha-aminooxylation01315nas a2200229   4500008004100000022001400041245014000055210006900195260000800264300001400272490000700286520049400293653002400787653002000811653002200831653001500853653002500868100002300893700001900916700002200935856012800957       2019                        eng d  a0376-469900aProline catalyzed sequential alpha-amination/ Prins/ Ritter amidation of aldehydes: new method of construction of tetrahydropyran units0 aProline catalyzed sequential alphaamination Prins Ritter amidati  cSEP  a1019-10280 v583 a<p>An efficient ``one-pot'' synthetic method toward highly substituted tetrahydrofuran (THP) units is reported. The key transformation involves an atom-efficient sequential proline catalyzed alpha-amination of aldehydes to give alpha-aminated aldehydes in situ and the subsequent cyclomerization with homoallylic alcohols under Prins/Ritter conditions. Notably, this method provides access to enantiopure 1,2-syn and 1,4-anti diamino alcohols via reductive ring opening of THP units.</p>
10aalpha-aminoxylation10aorganocatalysis10aProline catalyzed10asequential10atetrahydropyran unit1 aAhuja, Brijbhushan1 aGadakh, Sunita1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/proline-catalyzed-sequential-alpha-amination-prins-ritter-amidation-aldehydes-new-method01281nas a2200253   4500008004100000022001400041245016500055210006900220260000800289300001200297490000700309520036900316653001500685653002700700653001900727653002100746653002400767653002800791100001900819700002000838700002300858700002200881856012400903       2020                        eng d  a0376-469900aConcise enantioselective synthesis of (R)-(+)-goniothalamin oxide, a trypanocidal active agent via L-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde0 aConcise enantioselective synthesis of Rgoniothalamin oxide a try  cMAR  a393-3980 v593 a<p>A short and straight-forward enantioselective synthesis of (R)-(+)-goniothalamin oxide 2 has been achieved with an overall yield of 39% and 99% ee. The synthetic approach involves L-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde followed by Lewis acid-mediated diastereoselective allylation of epoxy aldehyde as the key chiral-inducing steps.</p>
10aAllylation10aasymmetric epoxidation10aEsterification10aGrubbs' catalyst10aL-prolinol catalyst10aRing closing metathesis1 aKumar, Senthil1 aMandle, Ram, D.1 aKamble, Sanjay, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-r-goniothalamin-oxide-trypanocidal-active-agent-l01235nas a2200229   4500008004100000022001400041245010300055210006900158260000800227300001400235490000700249520043000256653002600686653002000712653003000732653002500762100002600787700002000813700002300833700002200856856012700878       2020                        eng d  a0376-469900aP2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent0 aP2O5mediated FriedelCrafts acylation of activated arenes with ca  cDEC  a1861-18670 v593 a<p>P2O5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone.</p>
10a4-methoxyacetophenone10aCarboxylic acid10aFriedel-Crafts acylations10aphosphorus pentoxide1 aKalshetti, Rupali, G.1 aMandle, Ram, D.1 aKamble, Sanjay, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/p2o5-mediated-friedel-crafts-acylation-activated-arenes-carboxylic-acid-acylating-agent01441nas a2200277   4500008004100000022001400041245014000055210006900195260000800264300001400272490000900286520047600295653001100771653002200782653002800804653002000832653002200852100002500874700002000899700002300919700002100942700002300963700002200986700002501008856013001033       2020                        eng d  a1434-193X00aTriethyl phosphite/benzoyl peroxide mediated reductive dealkylation of O-benzoylhydroxylamines: a cascade synthesis of secondary amides0 aTriethyl phosphitebenzoyl peroxide mediated reductive dealkylati  cJUL  a4235-42380 v20203 a<p>A new triethyl phosphite/benzoyl peroxide (BPO) mediated system has been developed for the synthesis of secondary amides with good to excellent yields in a single step. This unprecedented cascade process involves sequential reduction of N-O bond and benzoylation followed by dealkylation of N-C bond ofO-benzoylhydroxylamines (O-BHA). The methodology is versatile as it tolerates a variety of aromatic and aliphaticO-BHA as substrates to access secondary amides.</p>
10aAmides10aCascade reactions10aO-Benzoylhydroxylamines10aRedox reactions10asynthetic methods1 aAegurla, Balakrishna1 aMandle, Ram, D.1 aShinde, Prasad, G.1 aParit, Ratan, S.1 aKamble, Sanjay, P.1 aSudalai, Arumugam1 aSenthilkumar, Beeran  uhttps://library.ncl.res.in/content/triethyl-phosphitebenzoyl-peroxide-mediated-reductive-dealkylation-o-benzoylhydroxylamines01587nas a2200229   4500008004100000022001400041245015600055210006900211260000800280300001400288490000700302520073500309653002101044653002001065653001401085653003501099653003501134100002301169700002201192700001701214856012601231       2022                        eng d  a0253-296400aStudies toward the total synthesis of (+)-neopeltolide using N-heterocyclic carbene-catalyzed oxo-acyloxylation/reductive oxa-Michael addition strategy0 aStudies toward the total synthesis of neopeltolide using Nhetero  cOCT  a1169-11720 v433 a<p>
	This article describes a concise synthesis of two important fragments (tetrahydropyran [THP] and ketone moieties) of the cytotoxic macrolide (+)-neopeltolide in 10 long linear steps in enantiomerically pure form. Asymmetric Keck allylation to install the required C11 and C13 stereocenters, N-heterocyclic carbene (NHC)-catalyzed oxoacyloxylation to functionalize alkenes, and reductive oxa-Michael addition to construct 2,6-difunctionalized THP unit intramolecularly are the important steps in synthetic efforts. Finally, Keck asymmetric allylation and Lewis acid-catalyzed diastereoselective allylation of the aldehyde were sequentially employed to establish the stereocenters at C11 and C13 positions, respectively.</p>
10a(+)-neopeltolide10aKeck allylation10aMacrolide10aNHC-catalyzed oxoacyloxylation10areductive oxa-Michael addition1 aReddi, Rambabu, N.1 aSudalai, Arumugam1 aJo, Changbum  uhttps://library.ncl.res.in/content/studies-toward-total-synthesis-neopeltolide-using-n-heterocyclic-carbene-catalyzed-oxo