01469nas a2200193   4500008004100000022001400041245017400055210006900229260000900298300001400307490000700321520070700328100002101035700002001056700002101076700002501097700002401122856012901146       2021                        eng d  a0022-326300aAnnulation of enals with carbamoylpropiolates via NHC-catalyzed enolate pathway: access to functionalized maleimides/iso-maleimides and synthesis of aspergillus FH-X-2130 aAnnulation of enals with carbamoylpropiolates via NHCcatalyzed e  cJUL   a9466-94770 v863 aHerein we report the N-heterocyclic carbene (NHC)-catalyzed [3 + 2] annulation of alpha,beta-unsaturated aldehydes with carbamoylpropiolates via an unusual enolate pathway leading to the construction of highly functionalized maleimides or isomaleimides. The electronic effect imposed by the alkyl/aryl group present on the amide nitrogen of carbamoylpropiolates plays a crucial role in the selective formation of these important five-membered heterocyclic building blocks. The developed protocol is mild and tolerates a wide range of substituents on both substrates. The application of this protocol in the synthesis of the antibacterial natural product Aspergillus FH-X-213 has also been demonstrated.1 aViveki, Amol, B.1 aPol, Mahesh, D.1 aHalder, Priyanka1 aSonavane, Sameer, R.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/annulation-enals-carbamoylpropiolates-nhc-catalyzed-enolate-pathway-access-functionalized01687nas a2200229   4500008004100000022001400041245015300055210006900208260000800277490000700285520081400292653002601106653002401132653002101156653003701177653002501214653002701239653001201266100002501278700002401303856013001327       2023                        eng d  a1861-472800aEnantioselective intramolecular decarboxylative C-H bond func-tionalization of quinazolinones with amino acids by visible light photoredox catalysis0 aEnantioselective intramolecular decarboxylative CH bond function  cJUL0 v183 a<p>
	The direct visible light-mediated intramolecular decarboxylative C-H functionalization of Csp(2)-H bond adjacent to the nitrogen of a heteroarene has been achieved by iridium-catalyzed photodecarboxylative radical cyclization. This method offers rapid entry to the synthesis of quinazolinone scaffolds from easily accessible starting materials. The newly developed protocol is mild, operationally simple, oxidant free and general. The utility of this unique Csp(3)-Csp(2) bond forming reaction has been demonstrated in the syntheses of Circumdatin, Sclerotigenine and Benzomalvin A class of quinazolinone natural products and their congeners. The present work represents an interesting example of use of memory of chirality in decarboxylative C-C bond forming enantioselective photoredox reaction.</p>
10aC-H functionalization10amemory of chirality10aMinisci reaction10aphotodecarboxylative cyclization10aphotoredox catalysis10aquinazolinone alkaloid10aRadical1 aSonavane, Sameer, R.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/enantioselective-intramolecular-decarboxylative-c-h-bond-func-tionalization-quinazolinones01209nas a2200181   4500008004100000022001400041245012300055210006900178260000800247300001400255490000700269520053000276100002500806700002100831700002300852700002400875856012800899       2025                        eng d  a1523-706000aOrganophotoredox-catalyzed decarboxylative C-O/N/S bond formation: access to ampakine APIs and quinazolinone alkaloids0 aOrganophotoredoxcatalyzed decarboxylative CONS bond formation ac  cAPR  a3871-38760 v273 a<p>
	This study describes a novel and general protocol featuring organophotoredox-catalyzed intramolecular decarboxylative construction of carbon-heteroatom (oxygen, nitrogen, and sulfur) bonds, enabling direct access to ampakine APIs (CX-614 and CX-554), quinazolinone alkaloids (deoxyvasicinone and mackinazolinone), and thiazinone scaffolds as well as their congeners with broad functional group tolerance and scalability. Mechanistic studies suggest a radical-polar crossover pathway via single-electron oxidation.</p>
1 aSonavane, Sameer, R.1 aKale, Tushar, B.1 aBhatt, Gaurang, J.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/organophotoredox-catalyzed-decarboxylative-c-ons-bond-formation-access-ampakine-apis-and